A5059930571- COVID-19 Clinical Research Studies
- SARS-CoV-2 and COVID-19 Research
- Long-Term Effects of COVID-19
- Pneumonia and Respiratory Infections
- SARS-CoV-2 detection and testing
- Respiratory viral infections research
- COVID-19 and healthcare impacts
- Iron Metabolism and Disorders
- Hemoglobinopathies and Related Disorders
- Intensive Care Unit Cognitive Disorders
- Immune responses and vaccinations
- COVID-19 and Mental Health
- Respiratory Support and Mechanisms
- COVID-19 Impact on Reproduction
- Nosocomial Infections in ICU
- Pneumocystis jirovecii pneumonia detection and treatment
- Liver Disease Diagnosis and Treatment
- PARP inhibition in cancer therapy
- Inflammasome and immune disorders
- Sepsis Diagnosis and Treatment
- Antibiotic Resistance in Bacteria
- Pancreatitis Pathology and Treatment
- Colorectal Cancer Treatments and Studies
- Emergency and Acute Care Studies
- Complement system in diseases
UnityPoint Health
2025
University of Oslo
2014-2024
Oslo University Hospital
1984-2024
Johns Hopkins Hospital
2024
University of Oxford
2021
Drammen Hospital
2016-2019
Vestre Viken Hospital Trust
2015-2019
Akershus University Hospital
2014
Institutt for Eksperimentell Medisinsk Forskning
1981-1982
Significance The new SARS-CoV-2 pandemic leads to COVID-19 with respiratory failure, substantial morbidity, and significant mortality. Overactivation of the innate immune response is postulated trigger this detrimental process. complement system a key player in immunity. Despite few reports local activation, there lack evidence that degree systemic activation occurs early patients, whether associated failure. This study shows number products are systemically, consistently, long-lastingly...
Despite recent advances in microbiological techniques, the etiology of community-acquired pneumonia (CAP) is still not well described. We applied polymerase chain reaction (PCR) and conventional methods to describe CAP hospitalized adults evaluated their respective diagnostic yields. 267 patients were enrolled consecutively over our 3-year prospective study. Conventional (i.e., bacterial cultures, urinary antigen assays, serology) combined with nasopharyngeal (NP) oropharyngeal (OP) swab...
A high proportion of COVID-19 patients have cardiac involvement, even those without known disease. Downregulation angiotensin converting enzyme 2 (ACE2), a receptor for SARS-CoV-2 and the renin-angiotensin system, as well inflammatory mechanisms been suggested to play role. ACE2 is abundant in gut associated with microbiota composition. We hypothesized that leakage microbial products, subsequent inflammasome activation could contribute involvement patients.Plasma levels marker (LPS-binding...
Abstract In SARS-CoV-2 infection there is an urgent need to identify patients that will progress severe COVID-19 and may benefit from targeted treatment. this study we analyzed plasma cytokines in investigated their association with respiratory failure (RF) treatment Intensive Care Unit (ICU). Hospitalized (n = 34) confirmed were recruited into a prospective cohort study. Clinical data blood samples collected at inclusion after 2–5 7–10 days. RF was defined as PaO2/FiO2 ratio (P/F) < 40...
Introduction Very little is known about possible clinical sequelae that may persist after resolution of acute COVID-19. A recent longitudinal cohort from Italy including 143 patients followed up hospitalisation with COVID-19 reported 87% had at least one ongoing symptom 60-day follow-up. Early indications suggest need even more psychological support than typical intensive care unit patients. The assessment risk factors for longer term consequences requires a study linked to data on...
Background. There is considerable variability in COVID-19 outcomes among younger adults, and some of this variation may be due to genetic predisposition.
To test the hypotheses that blood biomarkers for nervous system injury, serum concentrations of neurofilament light chain protein (NfL) and glial fibrillary acidic (GFAp) can serve as disease severity in COVID-19 patients.Forty-seven inpatients with confirmed had samples drawn on admission assessing CNS injury by Single molecule array (Simoa), NfL GFAp. Concentrations GFAp were analyzed relation to symptoms, clinical signs, inflammatory outcomes. We used multivariate linear models...
To determine the incidence and characteristics of superinfections in mechanically ventilated COVID-19 patients, impact dexamethasone as standard therapy.This multicentre, observational, retrospective study included patients ≥ 18 years admitted from March 1st 2020 to January 31st 2021 with infection who received mechanical ventilation. Patient characteristics, clinical therapy survival were examined.155/156 (115 men, mean age 62 years, range 26-84 years) included. 67 (43%) had 90...
Gut microbiota alterations have been reported in hospitalized COVID-19 patients, with reduced alpha diversity and altered composition related to respiratory failure. However, data regarding gut mortality are scarce.Rectal swabs for analyses were collected within 48 h after hospital admission (baseline; n = 123) three-month post-admission (n 50) a subset of patients included the Norwegian SARS-CoV2 cohort study. Samples analysed by sequencing 16S rRNA gene. at baseline assessed relation need...
Background Contributors to long-term mortality in patients with community-acquired pneumonia (CAP) remain unclear, little attention paid etiology. We examined survival, causes of death, and risk factors for adult who had been hospitalized CAP, emphasis on demographic, clinical, laboratory, microbiological characteristics. Methods Two hundred sixty-seven consecutive admitted 2008–2011 a general hospital CAP were prospectively recruited followed up. Patients died during stay excluded....
Diagnostic assays currently used to monitor the efficacy of COVID-19 vaccines measure levels antibodies receptor-binding domain ancestral SARS-CoV-2 (RBDwt). However, predictive value for protection against new variants concern (VOCs) has not been firmly established. Here, we bead-based arrays and flow cytometry binding spike proteins domains (RBDs) from VOCs in 12,000 serum samples. Effects sera on RBD-ACE2 interactions were measured as a proxy neutralizing antibodies. The samples obtained...
Abnormal remodelling of the extracellular matrix (ECM) has generally been linked to pulmonary inflammation and fibrosis may also play a role in pathogenesis severe COVID-19. To further elucidate ECM excessive fibrogenesis COVID-19, we examined circulating levels mediators involved various aspects these processes COVID-19 patients.
Abstract Background The complement system, an upstream recognition system of innate immunity, is activated upon SARS‐CoV‐2 infection. To gain a deeper understanding the extent and duration this activation, we investigated activation profiles during acute phase COVID‐19, its persistence post‐recovery dynamic changes in relation to disease severity. Methods Serial blood samples were obtained from two cohorts hospitalized COVID‐19 patients ( n = 457). Systemic products reflecting...
A proportion of people develop Long Covid after acute COVID-19, but with most studies concentrated in high-income countries (HICs), the global burden is largely unknown. Our study aims to characterise long-term COVID-19 sequelae populations globally and compare prevalence reported symptoms HICs low-income middle-income (LMICs).
Abstract Background Immune dysregulation is a major factor in the development of severe coronavirus disease 2019 (COVID-19). The homeostatic chemokines CCL19 and CCL21 have been implicated as mediators tissue inflammation, but data on their regulation acute respiratory syndrome 2 (SARS-CoV-2) infection limited. We thus investigated levels these COVID-19 patients. Methods Serial blood samples were obtained from patients hospitalized with (n = 414). Circulating during hospitalization 3-month...
Abstract Disclaimer In an effort to expedite the publication of articles, AJHP is posting manuscripts online as soon possible after acceptance. Accepted have been peer-reviewed and copyedited, but are posted before technical formatting author proofing. These not final version record will be replaced with article (formatted per style proofed by authors) at a later time. Purpose The prevalence Candida infections increases each year in US. most common species albicans, glabrata, parapsilosis,...
Objective. Based on the function of fractalkine (CX3CL1), unique member CX3C chemokine subfamily, in endothelial-related inflammation, we hypothesized a role for CX3CL1 and its receptor (CX3CR) Wegener's granulomatosis (WG). In present study, this hypothesis was tested by different experimental approaches. Methods. We examined plasma levels (enzyme immunoassay) CX3CR1 expression peripheral blood mononuclear cells (PBMCs) (real-time quantitative RT-PCR flow cytometry) 18 WG patients 15...
Abstract Background The inflammatory response to community‐acquired pneumonia ( CAP ) is orchestrated through activation of cytokine networks and the complement system. We examined association multiple cytokines terminal complex TCC with microbial aetiology, disease severity short‐term outcome. Materials methods Plasma levels 27 were analysed in blood samples obtained at hospital admission, clinical stabilization 6‐week follow‐up from 247 hospitalized adults . Fourteen mediators included...
Biomarkers may facilitate clinical decisions in order to guide antimicrobial treatment and prediction of prognosis community-acquired pneumonia (CAP). We measured serum C-reactive protein, procalcitonin (PCT) calprotectin levels, plasma pentraxin 3 (PTX3) presepsin along with whole-blood white cell counts, at three time-points, examined their association microbial aetiology adverse outcomes CAP.Blood samples were obtained hospital admission, stabilisation 6-week follow-up from 267...
Abstract Background Prognostic markers for disease severity and identification of therapeutic targets in COVID‐19 are urgently needed. We have studied innate adaptive immunity on protein transcriptomic level patients with different at admission longitudinally during hospitalization. Methods Peripheral blood mononuclear cells (PBMCs) were collected three time points from 31 included the Norwegian SARS‐CoV‐2 cohort study analysed by flow cytometry RNA sequencing. Patients grouped as either...
Abstract Background There is considerable variability in COVID-19 outcomes amongst younger adults—and some of this variation may be due to genetic predisposition. We characterized the clinical implications major risk factor for severity, and its age-dependent effect, using individual-level data a large international multi-centre consortium. Method The common chromosome 3 locus, tagged by marker rs10490770. combined individual level 13,424 positive patients (N=6,689 hospitalized) from 17...
Background Results showing that sera from double vaccinated individuals have minimal neutralizing activity against Omicron been interpreted as indicating the need for a third vaccine dose protection. However, there is little information about early immune responses to infection in individuals. Methods We measured inflammatory mediators, antibodies SARS-CoV-2 spike and nucleocapsid proteins, peptide-induced release of interferon gamma whole blood 51 double-vaccinated infected with Omicron, 14...
The Omicron variant of SARS-CoV-2 spreads more easily than earlier variants, possibly as a result higher viral load in the upper respiratory tract and oral cavity. Hence, we investigated whether generates that Delta saliva nasopharynx. Both specimens were collected from 52 17 cases at two time points one week apart analyzed by qRT-PCR. Viral was measured 10 log RNA genome copies per 1000 human cells according to WHO reference standard. We found carried had sustained shedding compared cases,...