A5070632624- Gut microbiota and health
- Nutrition and Health in Aging
- Diet and metabolism studies
- Nutritional Studies and Diet
- Wound Healing and Treatments
- Dermatology and Skin Diseases
- Food Security and Health in Diverse Populations
- Tryptophan and brain disorders
- Diabetic Foot Ulcer Assessment and Management
- Epigenetics and DNA Methylation
- Probiotics and Fermented Foods
- Research on Leishmaniasis Studies
- Reproductive System and Pregnancy
- Bee Products Chemical Analysis
- Immune Cell Function and Interaction
- Gastrointestinal motility and disorders
- Food composition and properties
- Allergic Rhinitis and Sensitization
- Coconut Research and Applications
- Pressure Ulcer Prevention and Management
- T-cell and B-cell Immunology
- Periodontal Regeneration and Treatments
- Toxin Mechanisms and Immunotoxins
- Insect and Pesticide Research
University of Pennsylvania
2023-2025
Instituto Nacional de Salud Pública
2022-2023
Universidad Nacional Autónoma de México
2022-2023
University of Wisconsin–Madison
2020-2021
There is general consensus that consumption of dietary fermentable fiber improves cardiometabolic health, in part by promoting mutualistic microbes and increasing production beneficial metabolites the distal gut. However, human studies have reported variations observed benefits among individuals consuming same fiber. Several factors likely contribute to this variation, including host genetic gut microbial differences. We hypothesized metabolism represents an important differential factor...
Strain-level variation in Staphylococcus aureus is a factor that contributes to disease burden and clinical outcomes skin disorders chronic wounds. However, the microbial mechanisms drive these variable host responses are poorly understood. To identify underlying strain-specific outcomes, we perform high-throughput phenotyping screens on S. isolates cultured from diabetic foot ulcers. Isolates non-healing wounds produce more staphyloxanthin, cell membrane pigment. In murine wounds,...
Chronic wounds are a common and costly complication of diabetes, where multifactorial defects contribute to dysregulated skin repair, inflammation, tissue damage, infection. We previously showed that aspects the diabetic foot ulcer microbiota were correlated with poor healing outcomes, but many microbial species recovered remain uninvestigated respect wound healing. Here, we focused on
We evaluated associations of smoking heaviness markers and the effects cessation on intestinal microbiota cardiovascular disease risk factors in current smokers undertaking a quit attempt. Participants were enrolled prospective randomized clinical trial therapies with visits at baseline, 2, 12 weeks. Genomic DNA was extracted from fecal samples followed by 16S rRNA gene sequencing analysis using QIIME2 software workflow. Relative abundances bacterial taxa alpha- beta-diversity measures used...
The development of metabolic diseases is linked to the gut microbiota. A cross-sectional study involving 45 children (6 12 years old) was conducted investigate relationship between microbiota and childhood obesity. Anthropometric measurements, food-frequency questionnaires (FFQs), feces samples were obtained. Using body mass index (BMI) z-score, we categorized each participant as normal weight (NW), or overweight obese (OWOB). We determined 2 dietary profiles: one with complex carbohydrates...
Gut microbiota is associated with the development of metabolic disorders. To study its association childhood obesity, we performed a cross-sectional 46 children (6-12 years old). We collected fecal samples, food-frequency questionnaires (FFQs), and anthropometric measurements. Shotgun metagenomics were used to obtain microbial taxonomic diversity potential. identified two dietary profiles characterized by complex carbohydrates proteins (pattern 1) saturated fat simple 2). classified each...
ABSTRACT The microbiota mediate multiple aspects of skin barrier function, including colonization resistance to pathogens such as Staphylococcus aureus . endogenous limits S. via competition and direct inhibition. Novel mechanisms are promising therapeutic targets for drug-resistant infections, those caused by methicillin-resistant (MRSA). Here, we developed characterized a swine model topical microbiome perturbation MRSA colonization. As in other systems, antimicrobial treatment had little...
The host-microbiota relationship has evolved to shape mammalian physiology, including immunity, metabolism, and development. Germ-free models are widely used study microbial effects on host processes such as immunity. Here, we find that both germ-free T cell-deficient mice exhibit a robust sebum secretion defect persisting across multiple generations despite colonization cell repletion. These phenotypes inherited by progeny conceived during in vitro fertilization using sperm eggs,...
Chronic wounds are a common and costly complication of diabetes, where multifactorial defects contribute to dysregulated skin repair, inflammation, tissue damage, infection. We previously showed that aspects the diabetic foot ulcer microbiota were correlated with poor healing outcomes, but many microbial species recovered remain uninvestigated respect wound healing. Here we focused on
Abstract Introduction We evaluated associations of smoking heaviness markers and the effects cessation on intestinal microbiota cardiovascular disease risk factors in current smokers undertaking a quit attempt. Methods Results Participants were enrolled randomized clinical trial therapies with visits, factor measurements, fecal collections at baseline, 2, 12 weeks after starting Genomic DNA was extracted from samples followed by 16S rRNA gene sequencing analysis using QIIME2 software...
Abstract BackgroundThere is general consensus that consumption of dietary fermentable fiber improves cardiometabolic health, in part by promoting mutualistic microbes and increasing production beneficial metabolites the distal gut. However, human studies have reported variations observed benefits among individuals consuming same fiber.Several factors likely contribute to this variation, including host genetic gut microbial differences. We hypothesized metabolism represents an important...