A5046579736- Ovarian cancer diagnosis and treatment
- Lung Cancer Treatments and Mutations
- Head and Neck Cancer Studies
- Endometrial and Cervical Cancer Treatments
- Gastric Cancer Management and Outcomes
- Intraperitoneal and Appendiceal Malignancies
- Health Systems, Economic Evaluations, Quality of Life
- Colorectal and Anal Carcinomas
- Colorectal Cancer Surgical Treatments
- Lung Cancer Diagnosis and Treatment
- Cancer Diagnosis and Treatment
- Healthcare cost, quality, practices
- Clinical practice guidelines implementation
- Preterm Birth and Chorioamnionitis
- Oral Health Pathology and Treatment
- Antibiotic Use and Resistance
- Economic and Financial Impacts of Cancer
- Cancer survivorship and care
- Global Cancer Incidence and Screening
- Innovations in Medical Education
- Reproductive Biology and Fertility
- Hip and Femur Fractures
- Autopsy Techniques and Outcomes
- Pharmaceutical Economics and Policy
- Multiple and Secondary Primary Cancers
Maastricht University Medical Centre
2025
Radboud University Nijmegen
2025
Radboud University Medical Center
2025
Belgian Health Care Knowledge Centre
2015-2024
Queen Elizabeth Hospital
2007-2016
University Medical Center Utrecht
2016
European Organisation for Research and Treatment of Cancer
2009-2010
European Organisation for Research and Treatment of Cancer
2008
Queen Elizabeth Hospital
2006
Primary debulking surgery before initiation of chemotherapy has been the standard care for patients with advanced ovarian cancer.We randomly assigned stage IIIC or IV epithelial carcinoma, fallopian-tube primary peritoneal carcinoma to followed by platinum-based neoadjuvant (so-called interval surgery).Of 670 a study treatment, 632 (94.3%) were eligible and started treatment. The majority these had extensive disease at (metastatic lesions that larger than 5 cm in diameter 74.5% 10 61.6%)....
Abstract Background Investigator-led multicentre randomised trials are essential to generate evidence on the optimal use of medical interventions. These non-commercial often hampered by underfunding, which may lead difficulties in gathering a team with necessary expertise, delayed trial start, slow recruitment and even early discontinuation. As new public funder pragmatic clinical trials, KCE Trials programme was committed correctly pay all activities order assure timely delivery...
Abstract Background Filgotinib is a preferential JAK1-inhibitor approved for the treatment of ulcerative colitis (UC). The ICC registry was developed to evaluate effectiveness and safety advanced therapies in inflammatory bowel disease (IBD). Here, we report one-year follow-up results filgotinib patients with UC. Methods Fourteen hospitals prospectively enrolled UC initiating Dutch registry. Treatment persistence assessed by Kaplan-Meier survival analysis. Clinical remission (i.e. Simple...
Abstract Background In Crohn’s disease (CD), artificial intelligence (AI) may improve treatment optimization and aid in clinical decision-making 1. The aim of the study is to compare results Bayesian Networks (BNs) both Expert Knowledge Model (EKM) Computer Algorithm Generated (CAGM) predicting corticosteroid-free remission at 52 weeks after introducing ustekinumab vedolizumab patients with CD. Methods Data were extracted from Dutch Initiative on Crohn Colitis (ICC) registry. Observations...
Abstract Background Although metastatic cutaneous melanoma is associated with an unfavorable prognosis, innovative therapies including immunomodulating agents and targeted have shown survival benefits in clinical trials. We assessed the impact of introduction drugs into practice on patients during period 2004–2017, Belgium. The evolution expenses was also analyzed. Methods This a retrospective population‐based study using data from national Belgian Cancer Registry, compulsory health...
Traditionally, women who have been treated for a gynecological cancer undergone long-term follow-up by hospital doctors. Recently, there has interest in alternative models of follow-up, including nurse-based review. The project compares patients' and professionals' views follow-up. A questionnaire was completed 96 attending routine clinics 32 professionals involved delivering large majority (82/96, 92%) (25/34, 73%) thought that should be provided doctor. However, were more likely to think...
Guidelines recommend surgery for Stage I-II, chemoradiation III and systemic therapy IV non-small cell lung cancer (NSCLC). However, patient related factors preferences influence treatment decisions. We investigated patterns of care Belgian NSCLC patients in 2010-2011, based on population-based data from the Cancer Registry administrative databases. The relationship between characteristics, institutional diagnostic volume, type survival was investigated. Overall, 20.8% received no...
To evaluate the quality of care for all patients diagnosed with lung cancer in Belgium based on a set evidence-based indicators and to study variability between hospitals.A retrospective linked data from registry, insurance claims vital status 2010 2011. Evidence-based were identified systematic literature search. A specific algorithm attribute centre was developed, funnel plots used assess centres.None.The proportion who received appropriate as defined by indicator. Secondary outcome...
Advanced ovarian cancer has a poor prognosis, with 5 year survival probability of <30%. Attempts to improve have focused on debulking surgery and systemic therapy. We assessed the evolution treatment patterns patients advanced epithelial specific attention changes in after introducing bevacizumab.Population based data from Belgian Cancer Registry were coupled administrative reimbursement compulsory health insurance organizations national database where date death is registered, patient's...