A5078392254- Neuroscience and Neuropharmacology Research
- Connexins and lens biology
- Neuroinflammation and Neurodegeneration Mechanisms
- Neurogenesis and neuroplasticity mechanisms
- Nicotinic Acetylcholine Receptors Study
- Biochemical effects in animals
- Neuroscience and Neural Engineering
- Neural dynamics and brain function
- Biochemical Analysis and Sensing Techniques
- Neuroscience of respiration and sleep
- Alzheimer's disease research and treatments
- S100 Proteins and Annexins
- Olfactory and Sensory Function Studies
Centre Interdisciplinaire de Recherche en Biologie
2017-2023
Inserm
2017-2023
Collège de France
2017-2023
Université Paris Sciences et Lettres
2017-2023
Centre National de la Recherche Scientifique
2017-2023
Champalimaud Foundation
2022-2023
Délégation Paris 5
2019
Pannexin-1 channel inhibition blocks seizure activity in brain slices from epileptic patients and reduces spontaneous seizures a mouse model of pharmacoresistant epilepsy.
Astrocytes play key roles in brain functions through dynamic interactions with neurons. One of their typical features is to express high levels connexins (Cxs), Cx43 and Cx30, the gap junction (GJ)-forming proteins. Cx30 involved basic cognitive processes shapes synaptic network activities, as shown by recent studies transgenic animals. Yet it remains unknown whether astroglial expression, localization, are endogenously dynamically regulated neuronal activity could therefore physiological...
Astroglial release of molecules is thought to actively modulate neuronal activity, but the nature, pathway, and cellular targets these neuroactive are still unclear. Pannexin 1, expressed by neurons astrocytes, form nonselective large pore channels that mediate extracellular exchange molecules. The functional relevance has been mostly studied in brain tissues, without considering their specific role different cell types, or neurons. Thus, our knowledge astroglial pannexin 1 regulation its...
The metabolic syndrome, which comprises obesity and diabetes, is a major public health problem the awareness of energy homeostasis control remains an important worldwide issue. balance finely regulated by central nervous system (CNS), notably through neuronal networks, located in hypothalamus dorsal vagal complex (DVC), integrate nutritional, humoral information from periphery. glial cells' contribution to these processes emerged few year ago. However, its underlying mechanism unclear. Glial...
Studies suggest that astrocytic connexins (Cx) have an important role in the regulation of high brain functions through their ability to establish fine-tuned communication with neurons within tripartite synapse. In light these properties, growing evidence suggests a Cx psychiatric disorders such as major depression but also therapeutic activity antidepressant drugs. However, real impact on treatment response and underlying neurobiological mechanisms remain yet be clarified. On this ground,...
Serotonin induces gene expression changes in astrocytes to regulate olfactory behavior.