A5075009607- Metallurgy and Material Forming
- Iterative Learning Control Systems
- Vibration and Dynamic Analysis
- Real-time simulation and control systems
- Criminal Law and Policy
- Semiconductor Lasers and Optical Devices
- Microstructure and Mechanical Properties of Steels
- Animal testing and alternatives
- Metal Forming Simulation Techniques
- RNA Research and Splicing
- Molecular Biology Techniques and Applications
- Computational Drug Discovery Methods
- Metal Alloys Wear and Properties
- Digitalization, Law, and Regulation
- Electron and X-Ray Spectroscopy Techniques
- Genomics, phytochemicals, and oxidative stress
- Advanced Control Systems Optimization
- Advanced Chemical Sensor Technologies
- Epigenetics and DNA Methylation
- Immunotoxicology and immune responses
- Biochemical Analysis and Sensing Techniques
- Bioinformatics and Genomic Networks
- Autonomous Vehicle Technology and Safety
- German Security and Defense Policies
- Advanced Multi-Objective Optimization Algorithms
Fraunhofer Institute for Toxicology and Experimental Medicine
2021-2024
RWTH Aachen University
2016-2020
University of Applied Sciences Emden Leer
2017
Technicolor (France)
1981
Institut de Physique
1980
Université Claude Bernard Lyon 1
1980
Institut National de Physique Nucléaire et de Physique des Particules
1980
Read-across approaches often remain inconclusive as they do not provide sufficient evidence on a common mode of action across the category members. This read-across case study thirteen, structurally similar, branched aliphatic carboxylic acids investigates concept using human-based new approach methods, such in vitro and silico models, to demonstrate biological similarity. Five out thirteen analogues have preclinical vivo studies. Three them induced lipid accumulation or hypertrophy studies...
Precise manufacturing of cold rolled, thin, and narrow metallic strips has become more important for various applications. The overall aim is the reduction thickness tolerances steel copper to an extent less than 1 um. To reach that goal, experimental rolling mill set up in which supplementary piezoelectric stack actuators are integrated. setup machine presented. It contains a real-time system rapid control prototyping using model-based development. enables direct download controller from...
This case study explores the applicability of transcriptome data to characterize a common mechanism action within groups short-chain aliphatic α-, β-, and γ-diketones. Human reference in vivo indicate that α-diketone diacetyl induces bronchiolitis obliterans workers involved preparation microwave popcorn. The other three α-diketones induced inflammatory responses preclinical animal studies, whereas beta gamma diketones addition caused neuronal effects. We investigated early transcriptional...
Abstract This project evaluated the applicability of existing alternative data, such as chemical, biological and metabolite similarity, to improve selection relevant source compound (SC). information was modularly integrated into read‐across (RAX) case studies addressing systemic toxicity after repeated exposure or developmental toxicity. For this purpose, data‐rich reference classes pesticides were defined, with propiconazole iodosulfuron methyl sodium target compounds (TCs). The...
Exposure Croups of Mice in the 2-YearFeed Studies Ethylene Thioureaa F, Concentrationb (ppm)
This paper presents the "IRT-Buggy", a model vehicle that is designed as platform for research and education developed at RWTH Aachen University. With two steered front wheels powered rear wheels, it can reach speeds of approx. 45km/h weight slightly over 60kg. The vehicle's non-holonomous 2D kinematics are very comparable to ones typical passenger vehicle. It equipped with sensors in similar form also found vehicles, such wheel speed sensors, inertial GNSS sensor. Throughout development...
In cold rolling, a precise roll gap adjustment is indispensable for manufacturing strips with accurate thickness. This paper proposes linear model predictive controller in rolling mill. As part of an automatic gauge control, the according to incoming strip thickness profile vital. The measurement that buffered, filtered zero-phase and length-based filter converted reference trajectory meet needs controller. Knowing as well actuator dynamics, can adjust disturbances right on time....
In the electrical and medical industries trend towards further miniaturization of devices is accompanied by demand for smaller manufacturing tolerances. Such use a plentitude small narrow cold rolled metal strips with high thickness accuracy. Conventional rolling mills can hardly achieve improvement these However, model-based controller in combination an additional piezoelectric actuator dynamic roll adjustment expected to enable production required tolerance +/-1 µm. The has be based on...
The use of cell-size parameters from oak trees as a powerful proxy for past climate reconstruction needs to be more intensively studied. freeware tool CATS will help pushing these high-volume measurements. In this study, we analyzed the response vessel size chronologies daily meteorological records. For purpose, developed computer-aided tree-ring analysis software (CATS) To stress test CATS, quantitative were measured in 22 living ring-porous two riparian-like forests (Mainfranken, southern...
Almost all metal strips with thicknesses of < 2 mm are produced by cold rolling. Thickness variations rolled caused various factors like fluctuation in strength the material, eccentricity rolls or thickness variation incoming strip. As demands concerning ever increasing Institute Automatic Control and Metal Forming aim at reducing tolerance thin, cold-rolled steel copper to 1 μm. high frequency disturbances expected, it is assumed that this goal can only be achieved using a predictive...
In this paper, the use of a "Built-in HiL" simulator mode is proposed for speeding up development higherlevel navigation- and communication-based control systems that are built upon automated base platforms. It to extend software platform controller such it does not only contain algorithms needed operation, but also simplified real-time models actuator, sensor vehicle dynamics provides access to. The thereby enabled run in which takes over role HiL simulator. This Built-in allows close loop...
Telluride based chalcogenide glass fibers with improved optical mechanical and thermal properties are presented. These manufactured by using a plastic-glass multiple co-drawing technique. The loss in the 6-11 micron range is between 0.2 3 dB/m.
The methods implemented in our laboratory-far field, near refracted and interfetometry-allow one to characterize very accurately the parameters of a step-index single-mode fiber by comparing results. profile is obtained with silica core borosilicate cladding MCVD process. Experimental results from above techniques show good match, confirming validity usual assumptions founding theories employed. Among used, field seems better check any type index profile, delicate task perform other methods.
Piezoelectric actuators are used in a variety of technical processes. Due to their ceramic nature, they can be processes where high compressive loads occur. This enables them as for roll gap adjustment cold rolling mill narrow strips. However, local gain is significantly dependent on the current operating point with respect applied voltage and loads. These fluctuations investigated, quantified, modeled this paper within scope operation range actuators. The resulting model develop sliding...
Cold rolling is a process that finishes the production of flat steel and must therefore guarantee high strip precision. However, thickness produced in roll gap cannot be measured directly which makes its observation challenging. In this paper, model both mill frame as well cold rolled are optimized online using data. A Recursive Least Squares parameter estimator used to determine modulus offset stand, while adapted Gaussian Process Regression. The models then based controller adjusts...
This paper presents a mobile and highly flexible test platform for developing validating Global Navigation Satellite System (GNSS) applications. Therefore versatile vehicle, developed at the Institute of Automatic Control RWTH Aachen University (IRT), referred to as “IRT-Buggy” is introduced. It fills gap between simulation full scale experiments. The results shown in this are generated context railway motivated project called Galileo Online: GO!. For presented application, “Virtual...
Model predictive control (MPC) has been used in a variety of industrial processes. Due to its large computation time application fast and complex processes is limited. Therefore, reducing complexity focus intense research. In this paper, reduction strategy for linear MPC developed. It the an over-actuated roll gap with two different actuator types cold rolling mill. One actuators able accept new set points only at much slower sample than actuator. order coordinate actuators, moving...
Next-generation risk assessment relies on mechanistic data from new approach methods, including transcriptome data. Various technologies, such as high-throughput targeted sequencing methods and microarray technologies based hybridization with complementary probes, are used to determine differentially expressed genes (DEGs). The integration of different requires a good understanding the differences arising use various technologies.To better understand between TempO-Seq platform Affymetrix...