A5065763059- Bioinformatics and Genomic Networks
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Genomics, phytochemicals, and oxidative stress
- Animal testing and alternatives
- Advanced Chemical Sensor Technologies
- Pesticide Exposure and Toxicity
- Cytokine Signaling Pathways and Interactions
- Carcinogens and Genotoxicity Assessment
- Genetically Modified Organisms Research
- interferon and immune responses
- Immunotoxicology and immune responses
- RNA Research and Splicing
- Pesticide Residue Analysis and Safety
Fraunhofer Institute for Toxicology and Experimental Medicine
2021-2024
Although the immunomodulatory and cytoprotective properties of itaconate have been studied extensively, it is not known whether its naturally occurring isomers mesaconate citraconate similar properties. Here, we show that partially converted to intracellularly accumulation in macrophage activation depends on prior synthesis. When added human cells supraphysiological concentrations, all three reduce lactate levels, whereas strongest succinate dehydrogenase (SDH) inhibitor. In infected with...
Abstract In the European Union, all chemical substances that are manufactured, imported or used in tonnages equal higher than one tonne per year must be registered under REACH regulation. This regulatory framework requires collection and dissemination of detailed information on properties, uses, potential health environmental impacts chemicals. However, some these chemicals may pose emerging risks food chain, necessitating development approaches to identify assess such risks. The SCREENER...
This case study explores the applicability of transcriptome data to characterize a common mechanism action within groups short-chain aliphatic α-, β-, and γ-diketones. Human reference in vivo indicate that α-diketone diacetyl induces bronchiolitis obliterans workers involved preparation microwave popcorn. The other three α-diketones induced inflammatory responses preclinical animal studies, whereas beta gamma diketones addition caused neuronal effects. We investigated early transcriptional...
Exposure Croups of Mice in the 2-YearFeed Studies Ethylene Thioureaa F, Concentrationb (ppm)
For many industrial chemicals toxicological data is sparse regarding several regulatory endpoints, so there a high and often unmet demand for NAMs that allow screening prioritization of these chemicals. In this proof concept case study we propose multi-gene biomarkers compounds' ability to induce lung fibrosis demonstrate their application