A5009040676- Adrenal Hormones and Disorders
- Bone health and treatments
- Bone health and osteoporosis research
- Hormonal Regulation and Hypertension
- Bone Metabolism and Diseases
- Autoimmune Bullous Skin Diseases
- Vitamin D Research Studies
- Cell Adhesion Molecules Research
- Dermatological and Skeletal Disorders
- Heavy Metal Exposure and Toxicity
- Spondyloarthritis Studies and Treatments
- Aluminum toxicity and tolerance in plants and animals
- Immune Cell Function and Interaction
- Sphingolipid Metabolism and Signaling
- Pancreatic and Hepatic Oncology Research
- Heparin-Induced Thrombocytopenia and Thrombosis
- Urticaria and Related Conditions
- Bone and Joint Diseases
- Trace Elements in Health
- Immune Response and Inflammation
- Mast cells and histamine
- Growth Hormone and Insulin-like Growth Factors
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Cellular transport and secretion
- Psoriasis: Treatment and Pathogenesis
National Research Council
2023
Manipal Academy of Higher Education
2018
University of Verona
2013-2016
Center for Rheumatology
2014
657 Oslo
2013
Neural differentiation, synaptic transmission, and action potential propagation depend on membrane sphingolipids, whose metabolism is tightly regulated. Mutations in the ceramide transporter CERT (CERT1), which involved sphingolipid biosynthesis, are associated with intellectual disability, but pathogenic mechanism remains obscure. Here, we characterize 31 individuals de novo missense variants CERT1. Several fall into a previously uncharacterized dimeric helical domain that enables...
<h3>Background</h3> Glucocorticoids (GLs) are the sole therapeutic approach in Polymyalgia rheumatica (PMR). An undefined proportion of patients respond only to very high doses GLs and some seem better methylprednisolone (MPONE) than prednisone (PN) or vice-versa. <h3>Objectives</h3> The aim this study is compare MPONE PN terms clinical response on their effect HPA axis initiating GL treatment for PMR. <h3>Methods</h3> 53 PMR were randomized (ratio 1/1) a fixed daily dose (25 mg) (20 was...
<h3>Background</h3> It has been demonstrated that IL-17A is able to induce GC insensitivity. Although several studies have reported the role of IL-17 in insensitivity mechanism underlying remains still largely unclear. <h3>Objectives</h3> To understand effects interleukin-17 (IL-17) on enzyme 11β-hydroxysteroid dehydrogenases (11β-HSDs) two main classes monocytes, CD14 and CD16. <h3>Methods</h3> Peripheral Blood Mononuclear Cells (PBMCs) were isolated from 5 healthy donors sorted into CD16...