A5073641829- Cancer Genomics and Diagnostics
- Drug Transport and Resistance Mechanisms
- Cholesterol and Lipid Metabolism
- Radiomics and Machine Learning in Medical Imaging
- Colorectal Cancer Treatments and Studies
- Gastric Cancer Management and Outcomes
- Colorectal Cancer Screening and Detection
- Immunotherapy and Immune Responses
- Liver Disease Diagnosis and Treatment
- Cancer, Lipids, and Metabolism
- Cancer Diagnosis and Treatment
- Lysosomal Storage Disorders Research
- AI in cancer detection
- Cancer-related Molecular Pathways
- Eicosanoids and Hypertension Pharmacology
- Genetic factors in colorectal cancer
- Lung Cancer Treatments and Mutations
- Diagnosis and treatment of tuberculosis
- Cancer Immunotherapy and Biomarkers
- Autoimmune Bullous Skin Diseases
- Tumors and Oncological Cases
- Colorectal Cancer Surgical Treatments
- Peripheral Nerve Disorders
- Cardiovascular Health and Risk Factors
- Inflammatory mediators and NSAID effects
Tempus Labs (United States)
2022-2025
University of Michigan
2024
University of British Columbia
2024
Northwestern University
2019-2021
Duke University
2020
Icahn School of Medicine at Mount Sinai
2020
Johns Hopkins University
2020
The University of Texas Southwestern Medical Center
2012-2019
Stony Brook Medicine
2019
University of Illinois Urbana-Champaign
2008
Carboxylesterases (CES) are a well recognized, yet incompletely characterized family of proteins that catalyze neutral lipid hydrolysis. Some CES have well-defined roles in xenobiotic clearance, pharmacologic prodrug activation, and narcotic detoxification. In addition, emerging evidence suggests other may metabolism. Humans six <i>CES</i> genes, whereas mice 20 <i>Ces</i> genes grouped into five isoenzyme classes. Perhaps due to the high sequence similarity shared by mouse tissue-specific...
Importance Among patients with breast cancer, inconsistent findings have been published on racial disparities in achieving pathologic complete response (pCR) after neoadjuvant chemotherapy (NACT). Objective To investigate whether exist pCR and what factors contribute to them. Design, Setting, Participants Within the ongoing Chicago Multiethnic Epidemiologic Breast Cancer Cohort (ChiMEC), which consists of a prospectively ascertained cohort 690 stage I III cancer receiving NACT were...
Cancers assume a variety of distinct histologies, and may originate from myriad sites including solid organs, hematopoietic cells, connective tissue. Clinical decision-making based on consensus guidelines such as the National Comprehensive Cancer Network (NCCN) is often predicated specific histologic anatomic diagnosis, supported by clinical features pathologist interpretation morphology immunohistochemical (IHC) staining patterns. However, in patients with nonspecific morphologic IHC...
Abstract Microsatellite instability-high (MSI-H) is a tumor-agnostic biomarker for immune checkpoint inhibitor therapy. However, MSI status not routinely tested in prostate cancer, part due to low prevalence and assay cost. As such, prediction of from hematoxylin eosin (H&E) stained whole-slide images (WSIs) could identify cancer patients most likely benefit confirmatory testing evaluate their eligibility immunotherapy need Lynch syndrome testing. Prostate biopsies surgical resections...
The primary bile acid receptor farnesoid X (FXR) maintains lipid and glucose homeostasis by regulating expression of numerous acid-responsive genes, including an orphan nuclear metabolic regulator SHP. Using SHP as a model gene, we studied how FXR activity is regulated p300 acetylase. interaction with their recruitment to the promoter acetylated histone levels at were increased agonists in mouse liver HepG2 cells. In contrast, histones not detected FXR-null mice. directly interacted vitro....
Recent studies have indicated that using statins to inhibit the mevalonate pathway induces mutant p53 degradation by impairing interaction of with DnaJ subfamily A member 1 (DNAJA1). However, role C-terminus DNAJA1 a CAAX box for farnesylation in binding, folding, and translocation client proteins such as is not known. In present study, we used genetically engineered mouse model pancreatic carcinoma showed atorvastatin significantly increased animal survival inhibited carcinogenesis. There...
ABSTRACT Background Genomic fusions involving Protein Kinase C ( PKC or PRKC ) have been classically identified in a subset of melanocytic neoplasms with heavy melanin pigmentation as described older series. They were recently reclassified from the pigmented epithelioid melanocytoma (PEM) category to blue nevus (BN) fifth edition World Health Organization (WHO) Classification Skin Tumors. Methods Herein, we report series eight mostly hypopigmented fusion tumors novel comprehensive molecular...
Background: Precision medicine relies on mutational profiling, but clinical actionability remains limited for many cancer patients. We evaluated the feasibility and of ex-vivo drug sensitivity testing across solid tumors, focusing rare cancers. This study uses PARIS® CLIA-certified test, assessing patient-derived tumor cells (PDTCs) responses to a broad oncology panel. Methods: Tumor specimens (biopsies, fluids, or surgical samples) were shipped our laboratory arrive within 48h cultured in...
The TP53 gene is the most frequently mutated in human cancers, and majority of mutations are missense mutations. As a result, these mutant p53 (mutp53) either directly lose wildtype (wtp53) tumor suppressor function or exhibit dominant negative effect over wtp53. In addition, some mutp53 have acquired new oncogenic (gain function). Therefore, targeting for its degradation may serve as promising strategy cancer prevention therapy. Based on our previous finding that farnesylated DNAJA1 crucial...
Cytochrome P450 epoxygenase is a major enzyme involved in the metabolism of ω-3 polyunsaturated fatty acids (PUFAs) to produce biologically active epoxy (ω-3 epoxides). In general, all PUFAs including epoxides are quickly metabolized/inactivated by soluble epoxide hydrolase (sEH) form diol products. The aims this study were determine effect and mechanism fat-1 transgene, PUFA combined with sEH gene knockout or inhibitor on inhibiting pancreatic cancer related mechanisms involved.PK03-mutant...
Cholesterol 7α-hydroxylase (CYP7A1) is the initiating and rate-limiting enzyme in neutral pathway that converts cholesterol to primary bile acids (BA). CYP7A1-deficient (Cyp7a1(-/-)) mice have a depleted BA pool, diminished intestinal absorption, accelerated fecal sterol loss, increased synthesis. To determine molecular physiological effects of restoring pool this model, adult female Cyp7a1(-/-) matching Cyp7a1(+/+) controls were fed diets containing cholic acid (CA) at modest levels [0.015,...
Anti-programmed cell death 1 (PD1) targeted immune checkpoint inhibitors such as nivolumab and pembrolizumab are increasingly used to treat advanced malignancies melanoma, non-small lung cancer, urothelial renal carcinoma.A rare but reported adverse effect of anti-PD1 therapy is bullous pemphigoid (BP), an autoimmune blistering disease directed against BP antigen 2 in the basement membrane epidermis.We present 3 cases secondary immunotherapy patients with melanoma cancer highlight diagnosis...
Background Individualized neoantigen-specific immunotherapy (iNeST) requires robustly expressed clonal neoantigens for efficacy, but tumor mutational heterogeneity, loss of neoantigen expression, and variable tissue sampling present challenges. It is assumed that are preferred targets immunotherapy, the distributions not well characterized across cancer types. Methods We combined multiregion sequencing (MR-seq) analysis five untreated, synchronously sampled metastatic solid tumors with...
<b><i>Introduction:</i></b> Basal cell carcinoma (BCC) is the most common skin malignancy in world. While lesions are treated using surgical methods, others may present as locally advanced or metastatic disease and not amenable to therapy alone. Treatment with sonic hedgehog pathway inhibitors (vismodegib, sonidegib) designed inhibit key signaling proteins gene pathways involved BCC reduce uncontrolled proliferation of basal cells complicated can be invaluable...
Cholesteryl esters are generated at multiple sites in the body by sterol O-acyltransferase (SOAT) 1 or SOAT2 various cell types and lecithin cholesterol acyltransferase plasma. Esterified triacylglycerol contained lipoproteins cleared from circulation via receptor-mediated bulk-phase endocytosis hydrolyzed lysosomal acid lipase within late endosomal/lysosomal (E/L) compartment. Then, through successive actions of Niemann-Pick C (NPC) 2 NPC 1, unesterified (UC) is exported E/L compartment to...
Abstract Responding to crime and non-crime policing demand in the increasingly complex environment calls for nuanced means of measuring demand. Complementing traditional counts, recent development harm indices provides one such means, whereby crimes are weighted by estimates their or severity. Analysis using has shown that high victims, offenders, locations times differ from people places unweighted counts would highlight as a priority police resource. However, apply only crime, so they...
Recent developments in emerging technology, such as artificial intelligence, robotics, and autonomous vehicles, have generated inquiries about the incorporation of these technologies into law, well philosophical ethical questions that accompany their use. This paper considers existing legal doctrine regulatory frameworks applied to niche area Level 3 vehicles. Specifically, this tort liability form negligence products liability, privacy risks, considerations relation Finally, societal risks...
242 Background: While the 5-year recurrence rate in early stage CRC is low (12%) and there currently limited role of adjuvant chemotherapy such cases, a unique subset patients (pts) will have late recurrences. To identify molecular signatures predictive after pts undergo intended curative resection, we employed 22 targeted gene NGS panel with CRC. Association between mutation status free survival (RFS) was analyzed. Methods: Pts I-II had their tumor prospectively sequenced 09/2015-12/2018 by...