A5080325796- Veterinary Equine Medical Research
- Osteoarthritis Treatment and Mechanisms
- Tendon Structure and Treatment
- Mesenchymal stem cell research
- Inflammatory mediators and NSAID effects
- Bone health and treatments
- Veterinary Pharmacology and Anesthesia
- Reproductive Physiology in Livestock
- Periodontal Regeneration and Treatments
- Orthopaedic implants and arthroplasty
- Bone fractures and treatments
- Genetic and phenotypic traits in livestock
- Veterinary medicine and infectious diseases
- Wound Healing and Treatments
- Bone health and osteoporosis research
- Veterinary Orthopedics and Neurology
- Immune Response and Inflammation
- Shoulder Injury and Treatment
- Neonatal and fetal brain pathology
- Spine and Intervertebral Disc Pathology
- Pharmacological Effects and Assays
- Neuroscience of respiration and sleep
- Sports Performance and Training
- Plant-Derived Bioactive Compounds
- Mast cells and histamine
Cornell University
2022-2025
New York State College of Veterinary Medicine
2022-2025
Michigan State University
2019-2023
The University of Sydney
2023
Royal North Shore Hospital
2020-2023
Michigan United
2021
Colorado State University
2013-2020
Colgate University
2006
The use of allogeneic bone marrow-derived mesenchymal stem cells (BMDMSCs) may provide an effective alternative to autologous BMDMSCs for treatment equine musculoskeletal injuries. However, concerns have been raised regarding the potential safety and effectiveness BMDMSCs. We conducted studies assess immunological properties compared with those For assessment inherent immunogenicity, relative ability stimulate spontaneous proliferation lymphocytes was compared. immunosuppressive activity two...
Incisional complications following exploratory celiotomy increase morbidity, extend hospitalisation and cost. Retrospective studies seek to identify risk factors measures for prevention of surgical site infection. The relatively high incidence incisional laparotomy necessitates identification ideal closure methods.The study sought the drainage within our hospital population, while determining practices that reduce drainage.Retrospective cohort study.A retrospective study, with telephone...
Abstract Objective To evaluate the use of mesenchymal stem cells (MSCs), autologous conditioned serum (ACS), platelet‐rich plasma (PRP), and protein solution (APS) for treatment equine musculoskeletal disease by diplomates American College Veterinary Surgery (ACVS), Sports Medicine Rehabilitation (ACVSMR). Study design Cross‐sectional study. Sample population Diplomates ( n = 423). Methods An email link was sent to ACVS ACVMR diplomates. A survey contained 59 questions regarding...
Objective: This study aimed to examine the influence of neodymium-doped yttrium aluminum garnet (Nd:YAG) laser irradiation on equine bone marrow-derived mesenchymal stem cell (MSC) viability, proliferation, and cytokine expression in vitro. Background: Photobiomodulation cells using monochromatic light is a technique designed cellular processes. Previous studies have shown dose-dependent effects low-level proliferation range types species. Evidence for 1064 nm wavelength near-infrared MSCs...
Abstract Platelet-rich plasma (PRP) and other platelet-derived products represent a subset of regenerative medicine have been researched in the veterinary community for treatment osteoarthritis, soft tissue wounds, tendinopathies, periodontitis, fracture repairs. PRP is simple to produce, relatively affordable, safe, can be delivered on site, making it an appealing therapeutic agent medicine. As orthobiologic one few interventions with clinical study support that possess anabolic potential....
Though circular exercise is commonly used in equestrian disciplines, it may be at the detriment of horses’ musculoskeletal system. To investigate effects on bone and joint health, 42 lambs were randomly assigned to a non-exercised control, straight-line, small circle, or large circle regime slow (1.3 m/s) fast (2.0 speed for 12 wk. Blood samples taken biweekly. Animals humanely euthanized upon study completion, fused third fourth metacarpals collected biomechanical testing density analysis....
Abstract Extra-label bisphosphonate (BP) use in juvenile horses is anecdotally reported, primarily for analgesic effects, despite limited scientific understanding of biologic impacts on skeletally immature undergoing exercise. The objective this study was to determine the effects clodronate disodium (CD), a form BP, endocrine regulators calcium. Thus, 32 yearling Quarter Horses were stratified by age (500 ± 13 d), body weight (BW; 336 26 kg), sex (n = 16 geldings, n fillies), and initial...
To determine the effect of intravenous regional limb perfusion (IVRLP) with a combination mepivacaine hydrochloride and amikacin sulfate on synovial fluid concentration, antimicrobial activity, mechanical nociceptive threshold (MNT).Experimental study.Healthy adult horses (n=9).One IVRLP treatment was randomly administered by cephalic vein each limb: alone (1 g in 60 mL saline) or 500 mg saline). Opposite treatments were repeated after 24 hour wash-out period. Amikacin concentration activity...
The sensitive period is a special time for auditory learning in songbirds. However, little known about perception and discrimination of song during this development. authors used go/no-go operant task to compare conspecific from reversed juvenile adult zebra finches (Taeniopygia guttata), test possible developmental changes syllable structure syntax. In Experiment 1, there were no age or sex differences the ability learn discrimination, birds discriminated forward primarily on basis local...
Abstract Objective To develop a novel technique for left paralumbar laparoscopic bilateral ovariectomy in standing, sedated mares. Study design Prospective descriptive clinical study. Animals Twelve client‐owned Methods Healthy mares with normal ovarian palpation and ultrasonographic appearance were enrolled. Horses restrained standing stocks administered variable rate infusion of sedation. A was performed 1 3 instrument portals. Access to the right ovary facilitated by retracting descending...
Summary Background Allogeneic bone marrow‐derived mesenchymal stem cells (BMDMSCs) could provide multiple advantages over autologous BMDMSCs, including creating an ‘off‐the‐shelf’ treatment together with the ability to control for donor variation. Objectives The objective of study was compare clinical and synovial fluid response normal equine joint pooled‐allogeneic BMDMSCs while controlling individual variation variations in intra‐articular injections. We hypothesised that, by animal...
Abstract Background Corticosteroids are a commonly used, inexpensive intra‐articular treatment for osteoarthritis which may increase the risk laminitis in horses due, part, to hyperinsulinaemia. Humans with metabolic syndrome experience increases insulin and glucose concentrations post‐injection, but responses unknown. Objectives To determine effect of single (IA) dose triamcinolone acetate (TA) on blood concentrations. Study design Before‐after study. Methods Ten normal regulation as...
Osteoarthritis (OA) is one of the most prevalent musculoskeletal diseases, affecting patients suffering from pain and physical limitations. Recent evidence indicates a potential inflammatory component disease, with both T-cells monocytes/macrophages potentially associated pathogenesis OA. Further studies postulated an important role for subsets cell lineages, such as Th1, Th2, Th17, T-regulatory lymphocytes, M1, M2, synovium-tissue-resident macrophages. However, interaction between local...
Abstract Background Allogeneic and autologous bone marrow‐derived mesenchymal stem cells (BMDMSCs) have been administered in equine joints for their anti‐inflammatory effects. However, allogeneic BMDMSC offer multiple clinical practical advantages. Therefore, it is important to determine the relative effectiveness of vs BMDMSCs. Objectives The objective study was compare inflamed joint response BMDMSCs injections, if either treatment generated an effect. Study design Randomised controlled...
Alternatives to antibiotics for prevention of respiratory tract infections in cattle are urgently needed given the increasing public and regulatory pressure reduce overall antibiotic usage. Activation local innate immune defenses upper is one strategy induce non-specific protection against infection with diverse array viral bacterial pathogens associated bovine disease complex (BRDC), while avoiding use antibiotics. Our prior studies rodent models demonstrated that intranasal administration...
Background: The effects of recombinant interleukin-1β (rIL-1β) have been described for the middle carpal joint (MCJ). However, we are unaware any studies that cytological response tibiotarsal (TTJ) to rIL-1β or compared clinical and responses MCJ TTJ following administration intra-articular rIL-1β. Such information is critical researchers planning use create acute synovitis models in horses. Objectives: To compare Methods: Twelve horses were used study. Eight received 75ng into four TTJ....