<h3>Background</h3> The aim of this study was to compare the frequency and volume dual energy CT (DECT) urate deposits in people with asymptomatic hyperuricaemia symptomatic gout. <h3>Methods</h3> We analysed DECT scans feet from individuals serum ≥540 µmol/L (n=25) those crystal proven gout without clinically apparent tophi (n=33). <h3>Results</h3> were observed 6/25 (24%) participants hyperuricaemia, 11/14 (79%) early (predefined as disease duration ≤3 years) 16/19 (84%) late (p&lt;0.001)....

<h3>Objective:</h3> The underlying basis of bone erosion in gout remains speculative. aim this study was to understand the mechanisms using non-invasive imaging techniques. <h3>Methods:</h3> Paired plain radiographs and computed tomography (CT) scans 798 individual hand wrist joints from 20 patients with were analysed. Radiographs scored for (0–5) Sharp/van der Heijde method. CT presence diameter erosions tophi. intraosseous tophus (tophus visualised within bone) recorded. relationships...

In Brief Study Design. A retrospective review of 303 MRI scans the lumbar spine was conducted. Objectives. To determine prevalence facet joint synovial cysts arising from joints anteriorly and posteriorly. examine association these with osteoarthritis degenerative disc disease. Summary Background Data. Sporadic reports such exist as do limited studies describing symptomatic anterior cysts. However, overall has not been formally studied, mechanism formation is fully understood. Methods. One...

To examine the frequency and patterns of monosodium urate (MSU) crystal deposition in tendons ligaments patients with gout using dual-energy CT (DECT).Ninety-two tophaceous had DECT scanning both feet. Two readers scored scans for MSU at 20 tendon/ligament sites 42 bone (total 1840 3864 sites).MSU was observed by 199/1840 (10.8%) 399/3864 (10.3%) (p=0.60). The Achilles tendon most commonly involved site (39.1% all tendons), followed peroneal (18.1%). Tibialis anterior extensor were less...

Objective To examine whether allopurinol dose escalation to achieve serum urate ( SU ) target can influence bone erosion or monosodium MSU crystal deposition, as measured by dual‐energy computed tomography DECT in patients with gout. Methods We conducted an imaging study of a 2‐year randomized clinical trial that compared immediate conventional dosing for 1 year followed target, gout who were receiving and had level ≥0.36 mmoles/liter. scans feet radiographs hands obtained at baseline, 1, 2...

MRI bone oedema has been observed in early and advanced RA may represent a cellular infiltrate (osteitis) subchondral bone. We studied scans from patients undergoing surgery, seeking to identify regions of examine its histopathological equivalent resected bone.Preoperative contrast-enhanced were obtained 11 scheduled for orthopaedic surgery the hands/wrists or feet. In 9, scored by 2 readers (RAMRIS system). Its distribution with respect surgical site was investigated. 4 patients, 7 samples...

Objectives: Magnetic resonance imaging (MRI) bone oedema is an important predictor of erosion in rheumatoid arthritis (RA). This study aimed to determine the cellular components MRI oedema, and clarify relationship between oedema. Methods: Twenty-eight bones from 11 patients with RA undergoing orthopaedic surgery were analysed by quantitative semi-quantitative immunohistochemistry. Pre-operative contrast-enhanced scans for Results: The density osteoclasts was higher those samples than...

Objectives The aim of this work was to examine the relationship between joint damage and monosodium urate (MSU) crystal deposition in gout. Methods Plain radiographs dual-energy CT (DECT) scans feet were prospectively obtained from 92 people with tophaceous Subcutaneous tophus count recorded. ten metatarsophalangeal joints scored on plain radiography for Sharp–van der Heijde erosion space narrowing (JSN) scores, presence spur, osteophyte, periosteal new bone sclerosis (920 total joints)....

Abstract Objective To identify a valid method to measure radiographic damage in patients with chronic gout. Methods The scoring that best represented individual joints was analyzed by comparing gold standard rheumatologist consensus global score recognized methods, including the Sharp/van der Heijde erosion and narrowing scores, Ratingen destruction score, Steinbrocker score. Ninety‐five proximal interphalangeal from 12 gout were included this analysis. Scoring of hand feet radiographs an...

Objectives. Bone erosion has been linked with tophus deposition in gout but the roles of osteitis (MRI bone oedema) and synovitis remain uncertain. Our aims this prospective 3 T MRI study were to investigate frequency these features determine their relation one another. Methods. scans wrist obtained 40 patients. Scans scored independently by two radiologists for oedema, erosions, tophi synovitis. Dual-energy CT (DECT) a subgroup 10 Results. Interreader reliability was high erosions...

Abstract Objective Computed tomography (CT) has high accuracy for tophus detection. This study assessed reliability of CT measurement volume and compared reproducibility with physical size. Methods Forty‐seven hand tophi were analyzed in 20 patients gout. The longest diameter was recorded by 2 independent observers. All proceeded to scanning the hands on a Philips Brilliance scanner (0.8‐mm slices). Two observers measured using Surface Shaded Display 3‐dimensional function workstation. Five...

Background Dual-energy computed tomography (DECT) has recently been described as a sensitive method to detect urate deposits in patients with gout. Objectives The aim of this study was compare the reproducibility DECT various physical measurement methods tophus size assessment. Methods Sixty-four tophi from 25 were analyzed. Each assessed by 2 independent observers using Vernier calipers and tape measure. All proceeded scanning both feet. Urate volume within index automated assessment...

Radiographic descriptions of gout have noted the tendency to hypertrophic bone changes. The aim this study was characterize features new formation (NBF) in gout, and determine relationship between NBF other radiographic disease, particularly erosion tophus. Paired plain radiographs (XR) computed tomography (CT) scans 798 individual hand wrist joints from 20 patients with were analyzed. Following a structured review separate set images, films scored for presence following NBF: spur,...

Tophi are strongly associated with structural damage in gout, and urate-lowering therapy reduces tophus size. Pegloticase leads to dramatic reductions serum urate subcutaneous tophi treatment responders. The aim of this analysis was examine whether profound lowering can alter radiographic findings gout.Serial plain radiographs the hands feet were obtained from 8 patients tophaceous gout treated pegloticase. Radiographs scored for erosion joint space narrowing (JSN) according gout-modified...

To determine the effect of pioglitazone on bone marrow fat in humans.Twenty participants a double-blind, randomized, placebo-controlled trial skeletal effects 30 mg daily type 2 diabetes mellitus (T2DM) entered 6-month substudy evaluating fat. Main outcome measures were lumbar spine (L4) and proximal femur (intertrochanteric region), measured using magnetic resonance (MR) imaging, mineral density (BMD), dual-energy X-ray absorptiometry.after 6 months, change fourth vertebra (l4) lipid...

Objectives. Imaging and pathology studies have established a close relationship between tophus bone erosion in gout. The is an organized structure consisting of urate crystals chronic inflammatory tissue. aim this work was to examine the each component tophus. Methods. Plain radiographs dual energy CT scans feet were prospectively obtained from 92 people with tophaceous 10 MTP joints scored for score, soft tissue volume. Data analysed using generalized estimating equations mediation...

It is currently unknown whether bone erosion in gout occurs through an 'inside-out' mechanism due to direct intra-osseous crystal deposition or 'outside-in' from the surface of bone. The aim this study was examine ('outside-in' vs. 'inside-out') monosodium urate (MSU) gout. Specifically, we used three-dimensional dual-energy computed tomography (DECT) analyse positional relationship between and MSU tophaceous gout, determine absence erosion. One hundred forty-four participants with at least...

Selective use of image-guided large-core needle biopsy the breast: accuracy and cost-effectiveness.A J Doyle, K A Murray, E W Nelson D G BraggAudio Available | Share

Abstract Introduction The aim of this study was to investigate the magnetic resonance imaging (MRI) features bone disease in arthritis mutilans (AM) form psoriatic (PsA). Methods Twenty-eight patients with erosive PsA were enrolled (median duration 14 years). Using x-rays both hands and feet, 11 classified as AM 17 non-AM (erosive without lysis)by two observers. MRI scans (1.5T) dominant hand (wrist fingers scanned separately) obtained using standard contrast-enhanced T1-weighted...

Objectives. To develop a method of scoring bone erosion in the feet patients with gout using CT as an outcome measure for chronic studies, consistent components OMERACT filter. Methods. Clinical assessment, plain radiographs and scans both were obtained from 25 gout. scored semi-quantitative based on Rheumatoid Arthritis MRI Scoring System (RAMRIS). was assessed at 22 bones each foot (total 1100 bones) by two independent radiologists. A number different models to determine optimal system...