A5069055927- Lung Cancer Treatments and Mutations
- Esophageal Cancer Research and Treatment
- Lung Cancer Diagnosis and Treatment
- RNA modifications and cancer
- Cancer Immunotherapy and Biomarkers
- Radiomics and Machine Learning in Medical Imaging
- Peptidase Inhibition and Analysis
- Epigenetics and DNA Methylation
- Lymphatic System and Diseases
- Protease and Inhibitor Mechanisms
- Cancer, Hypoxia, and Metabolism
- Lung Cancer Research Studies
- Cancer, Lipids, and Metabolism
- Metabolomics and Mass Spectrometry Studies
- Medical Imaging and Pathology Studies
- Cancer Genomics and Diagnostics
- Cancer-related molecular mechanisms research
- Alcohol Consumption and Health Effects
- Chemokine receptors and signaling
- Nitric Oxide and Endothelin Effects
- Angiogenesis and VEGF in Cancer
- Cancer-related Molecular Pathways
- Neuroscience of respiration and sleep
- Cancer-related gene regulation
- Glycosylation and Glycoproteins Research
University of Illinois Chicago
2025
Medical University of Białystok
2015-2024
Manchester Metropolitan University
2016
University of Pennsylvania
2015
Medical University of Vienna
2009
Sorbonne Université
2009
Institut Gustave Roussy
2009
Sahlgrenska University Hospital
2009
Université Paris-Sud
2009
Karolinska Institutet
2009
Purpose Based on 5-year or shorter-term follow-up data in recent randomized trials, adjuvant cisplatin-based chemotherapy is now generally recommended after complete surgical resection for patients with non–small-cell lung cancer (NSCLC). We evaluated the results of International Adjuvant Lung Cancer Trial study three additional years follow-up. Patients and Methods completely resected NSCLC were randomly assigned to four cycles observation. Cox models used evaluate treatment effect...
MicroRNAs (miRNAs) are small non-coding RNAs which regulate gene expression by base-pairing to the 3'-UTR of target mRNA. Recently, miRNAs have been shown cancer metastasis, however, central molecular mechanisms this ability still need be investigated. Epithelial mesenchymal transition (EMT), is characterized especially repression E-cadherin and increased cell motility, an essential component metastasis progression. In present study, we found that Snai1, a known transcriptional repressor...
Abstract Purpose: Current staging methods are imprecise for predicting prognosis of early-stage non–small-cell lung cancer (NSCLC). We aimed to develop a gene expression profile stage I and II NSCLC, allowing identification patients with high risk disease recurrence within 2 3 years after initial diagnosis. Experimental Design: used whole-genome microarrays analyze frozen tumor samples from 172 NSCLC (pT1-2, N0-1, M0) five European institutions, who had undergone complete surgical resection....
Incomplete understanding of the metastatic process hinders personalized therapy. Here we report most comprehensive whole-genome study colorectal metastases vs. matched primary tumors. 65% somatic mutations originate from a common progenitor, with 15% being tumor- and 19% metastasis-specific, implicating higher mutation rate in metastases. Tumor- metastasis-specific harbor elevated levels BRCAness. We confirm multistage progression new components ARHGEF7/ARHGEF33. Recurrently mutated...
As the current staging system is imprecise for estimating prognosis of early stage non-small cell lung cancer (NSCLC), it important to identify other methods selecting high-risk patients after failed surgical treatment. The aim study was evaluate expression 23 genes as putative prognostic markers in NSCLC. performed on 109 pairs tumor and matched unaffected tissue specimens taken from I II NSCLC patients. We evaluated mRNA level using real-time PCR method. difference between normal each gene...
Objective: Cannabidiol (CBD) has been suggested as a potential antihypertensive drug. The aim of our study was to investigate its vasodilatory effect in isolated human pulmonary arteries (hPAs) and rat small mesenteric (sMAs). Methods: Vascular effects CBD were examined hPAs obtained from patients during resection lung carcinoma sMAs spontaneously hypertensive (SHR); 11-deoxycorticosterone acetate (DOCA-salt) rats or their appropriate normotensive controls using organ bath wire myography,...
Identification of the NSCLC subtype at an early stage is still quite sophisticated. Metabolomics analysis tissue and plasma patients may indicate new, yet unknown, metabolic pathways active in NSCLC. Our research characterized metabolomics profile with advanced stage. Samples were subjected to thorough analyses using liquid chromatography-mass spectrometry (LC-MS) technique. Tissue and/or samples from 137 analyzed. Based on analysis, more than 200 metabolites differentiating adenocarcinoma...
It has been suggested that interleukin 6 (IL-6) plays a potential role in the growth and progression of tumors, including esophageal cancer (EC). The aim study was to compare clinical significance serum IL-6 with classic tumor markers – carcinoembryonic antigen (CEA) squamous cell (SCC-Ag) EC patients relation its histological types carcinoma esophagus (ESCC) adenocarcinoma (AD) esophagus. included 53 90 healthy subjects. Serum CEA levels were determined using immunoenzyme assays, while...
Objectives. Recent investigations have suggested that upregulated levels of inflammatory biomarkers, such as chemokines, may be associated with development many malignancies, including esophageal cancer (EC). Based on our knowledge, this study is the first to assess serum concentration chemokine CXCL12 and its specific receptor CXCR4 in diagnosis EC patients. Material Methods. The present included 79 subjects: 49 patients 30 healthy volunteers. concentrations classical tumor markers...
C-X-C motif chemokine 8 (CXCL-8), known as interleukin-8, is a pro-inflammatory cytokine which acts chemotactic factor, mainly for leukocytes. CXCL-8 produced by malignant cells, and therefore it can stimulate the growth progression of various neoplasms, including oesophageal cancer (OC). The aim current study was to measure serum concentrations in OC patients establish whether this protein might be considered potential candidate tumor marker diagnosis OC. included 50 subjects (32 with...
LncRNAs have arisen as new players in the world of non-coding RNA. Disrupted expression these molecules can be tightly linked to onset, promotion and progression cancer. The present study estimated usefulness 14 lncRNAs (HAGLR, ADAMTS9-AS2, LINC00261, MCM3AP-AS1, TP53TG1, C14orf132, LINC00968, LINC00312, TP73-AS1, LOC344887, LINC00673, SOX2-OT, AFAP1-AS1, LOC730101) for early detection non-small-cell lung cancer (NSCLC). total RNA was isolated from paired fresh-frozen cancerous noncancerous...
Biobanks are vital for high-throughput translational research, but the rapid development of novel molecular techniques, especially in omics assays, poses challenges to traditional practices and recommendations. In our study, we used biospecimens from oncological patients Polish clinics collaborated with Indivumed Group. For serum/plasma samples, monitored hemolysis, controlled RNA extraction, assessed cDNA library quality quantity, verified NGS raw data. Tissue samples underwent pathologic...
Cervical cancer is the fourth most common in women. Early detection with screening methods can help to prevent mortality. below national standards at a Midwest Federally Qualified Health Center and may compromise future funding. A manual chart review of cervical was compared an electronic health record-generated report found results from outside facilities accounted for 27% metric's underperformance. This quality improvement project aimed improve Uniform Data System performance specific...
Background The endocannabinoid anandamide is implicated in the pathogenesis of hypotension haemorrhagic, endotoxic, and cardiogenic shock. It has been demonstrated animal, but not human, vessels that vasodilatory effects abnormal cannabidiol are partially mediated by an as yet unidentified endothelial cannabinoid receptor. Our study was performed to examine influence on human pulmonary artery. Methods Isolated arteries were obtained from patients without clinical evidence hypertension during...
The epigenetic inactivation of tumor suppressor genes may play an important role in the development and progression many cancer types, including lung cancer. Therefore, we investigated association between aberrant promoter methylation 2 genes: Death-Associated Protein Kinase (DAPK) Ras Association Domain Family 1A (RASSF1A) by using methylation-specific PCR, clinicopathological features prognosis 70 radically resected non-small cell cancers (NSCLCs). Hypermethylation DAPK RASSF1A promoters...
Introduction: Discrimination between adenocarcinoma (ADC) and squamous cell carcinoma (SCC) subtypes in non-small lung cancer (NSCLC) patients is a significant challenge oncology. Lipidomics analysis provides promising approach for this differentiation. Methods: In an accompanying paper, we explored oxPCs levels cohort of 200 NSCLC patients. research, utilized liquid chromatography coupled with mass spectrometry (LC-MS) to analyze the lipidomics profile matching tissue plasma samples from 25...
The endocannabinoid virodhamine is a partial agonist at the cannabinoid CB(1) receptor and full CB(2) receptor, relaxes rat mesenteric arteries through endothelial receptors. Its concentration in periphery exceeds that of anandamide. Here, we examined influence on human pulmonary artery.Isolated were obtained during resections for lung carcinoma. Vasorelaxant effects endothelium-intact vessels precontracted with 5-HT or KCl.Virodhamine, unlike WIN 55,212-2, relaxed 5-HT-precontracted...
7507 Background: Based on 4 to 5-year follow-up data in recent randomized trials, adjuvant cisplatin-based chemotherapy is now generally recommended after complete surgical resection for patients with non-small-cell lung cancer. We evaluated the results of IALT study, initially reported a 4.7 year (ASCO 2003), three additional years follow-up. Methods: Patients completely resected NSCLC were randomly assigned or four cycles observation. The dose cisplatin (total 300–400 mg/m2), drug be...
Lymph node metastasis is a characteristic of malignant cancers and observed more frequently in oesophageal cancer than other digestive tract cancers, making it one the most important prognostic factors. Vascular endothelial growth factors C (VEGF-C) D (VEGF-D) are lymphangiogenic human lymphangiogenesis associated with lymph metastasis. The aim study was to determine correlation between pre-treatment serum levels VEGF-C (sVEGF-C) VEGF-D (sVEGF-D) clinicopathologic features patients...
Tissue inhibitors of metalloproteinases (TIMP) and the matrix (MMP) are involved in spread cancer.We have evaluated metalloproteinases' (MMP-10, MMP-7) their inhibitors' (tissue - TIMP-1, TIMP-2) mRNA expression 61 esophageal cancer samples from patients who had undergone surgery, by using real-time quantitative RT-PCR, correlated results with patient clinicopathologic features.MMP-10, MMP-7, TIMP-2 were overexpressed 73%, 85%, 55% 42% samples, respectively. The MMP-10, tumor size. MMP-7...