Takashi Nishihara

ORCID: 0000-0003-4582-1438
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About
Contact & Profiles
Research Areas
  • Liver Disease Diagnosis and Treatment
  • Tracheal and airway disorders
  • Phase-change materials and chalcogenides
  • Hepatitis B Virus Studies
  • Hepatitis C virus research
  • Liquid Crystal Research Advancements
  • Liver Diseases and Immunity
  • Lung Cancer Treatments and Mutations
  • Vascular Anomalies and Treatments
  • Advanced MRI Techniques and Applications
  • Semiconductor Lasers and Optical Devices
  • Lung Cancer Research Studies
  • Liver Disease and Transplantation
  • Advanced Optical Imaging Technologies
  • Lung Cancer Diagnosis and Treatment
  • MRI in cancer diagnosis
  • Hepatocellular Carcinoma Treatment and Prognosis
  • Hepatitis Viruses Studies and Epidemiology
  • Brain Metastases and Treatment
  • Enzyme Catalysis and Immobilization
  • Ionic liquids properties and applications
  • Pulmonary Hypertension Research and Treatments
  • Perovskite Materials and Applications
  • Isotope Analysis in Ecology
  • Chalcogenide Semiconductor Thin Films

Fujifilm (Japan)
2022-2025

National Kinki Chuo Hospital for Chest Disease
2023-2025

Kishiwada City Hospital
2021-2022

Hitachi (Japan)
2013-2021

Panasonic (Japan)
2002-2019

Osaka Prefectural Medical Center
2016-2017

Tottori University
2015-2017

Graduate School USA
2017

Central Research Institute of Electric Power Industry
2013

Yokohama City University
2008-2009

Perovskite solar cells have received great attention because of their rapid progress in efficiency, with a present certified highest efficiency 23.3%. Achieving both high and thermal stability is one the biggest challenges currently limiting perovskite devices displaying at temperature frequently suffer from marked decrease efficiency. In this report, relationship between composition device examined. It revealed that Rb can suppress growth PbI2 even under -rich conditions decreasing Br ratio...

10.1002/adma.201806823 article EN Advanced Materials 2019-01-11

Subpopulations of lymphocytes in portal areas, especially infiltrating bile duct epithelia were analyzed by light and electron microscopy using indirect peroxidaselabeled antibody method monoclonal antibodies against pan-T (Leu 1), cytotoxic/suppressor T 2a), helper/inducer 3a) natural killer/K 7) suppressor 15) cells liver biopsy specimens from four patients with primary biliary cirrhosis. Bile ducts chronic nonsuppurative destructive cholangitis observed two patients. Leu 1+ 2+ frequently...

10.1002/hep.1840060309 article EN Hepatology 1986-05-01

Background: Afatinib is an effective first-line treatment for epidermal growth factor receptor (EGFR) mutation-positive advanced non-small cell lung cancer (NSCLC). However, few reports have addressed the influence of cerebrospinal fluid (CSF) penetration rate on efficacy afatinib in patients with central nervous system metastases. Therefore, we conducted a prospective multicenter trial to evaluate CSF and EGFR NSCLC leptomeningeal carcinomatosis. Patients Methods: Eleven...

10.21873/anticanres.11806 article EN Anticancer Research 2017-07-20

Background Metabolic phenotyping has become an important 'bird's-eye-view' technology which can be applied to higher organisms, such as model plant and animal systems in the post-genomics proteomics era. Although genotyping expanded greatly over past decade, metabolic languished due difficulty of 'top-down' chemical analyses. Here, we describe a systematic NMR methodology for stable isotope-labeling analysis metabolite mixtures systems. Methodology/Principal Findings The method includes...

10.1371/journal.pone.0003805 article EN cc-by PLoS ONE 2008-11-25

Organic–inorganic halide perovskites (OIHPs) have been intensively studied in recent years for use solar cells. Many studies reported the light-induced phenomena of OIHP materials and their In this study, we investigated influence a hole-transport layer (HTL) on degradation (LID) mixed cells, especially at OIHP/HTL interface, by hard X-ray photoelectron spectroscopy (HAXPES) impedance spectroscopy. HAXPES shows accumulation iodine metallic lead vicinity electron-transport layer/OIHP...

10.1021/acsaem.9b00709 article EN ACS Applied Energy Materials 2019-06-25

Abstract Purpose To investigate the utility of intracellular enhancement (ICE) technique which suppresses signals from extracellular space for evaluation hepatic function on gadoxetic acid-enhanced hepatobiliary-phase (HBP) images. Methods We subjected 67 patients with suspected neoplastic lesions to HBP imaging and without ICE [i-HBP, conventional-HBP (c-HBP)]. A radiologist calculated liver/spleen contrast (LSC) [LSC = signal intensity (SI) liver/SI spleen]. Receiver-operating analysis was...

10.1007/s00261-025-04817-y article EN cc-by Abdominal Radiology 2025-01-31

ABSTRACT We report a rare case of patient experiencing persistent exertional dyspnoea due to subacute, adhesive and immobile airway blood clot following haemoptysis. Cryoextraction with short freezing times, which fragmented the into small pieces, proved effective, despite previous reports on acute clots recommending longer times.

10.1002/rcr2.70155 article EN cc-by-nc-nd Respirology Case Reports 2025-03-01

Three types of triazolium cetyl-PEG10 sulfate ionic liquid were synthesized and their activation <italic>Burkholderia cepacia</italic> lipase was investigated.

10.1039/c7gc02319g article EN Green Chemistry 2017-01-01

Radial endobronchial ultrasound with a guide sheath (EBUS-GS) has improved the diagnostic outcomes of peripheral lung lesions. However, to our knowledge, reports on use EBUS-GS for diagnosis cavitary lesions are unavailable. Therefore, this study aimed assess effectiveness and safety (PCLLs).This was single-institution retrospective review PCLLs examined by using between July 2013 October 2015. The results different samples, including cytologic, histopathologic, microbiologic were analysed...

10.1186/s12890-016-0244-y article EN cc-by BMC Pulmonary Medicine 2016-05-11

Iron salt-catalyzed Friedel-Crafts alkylation of chiral α-aryl alcohols with a trimethylsilyl group was found to proceed retention the configuration hydroxyl as leaving group. The memory chirality this system stems from β-silyl effect on carbocation intermediate.

10.1021/acs.orglett.5b01582 article EN Organic Letters 2015-06-11

Lipases are among the most widely used enzymes applicable for various substrates; however, slow reactions or poor enantioselective sometimes obtained. To develop ionic liquid type activating agents lipase, four types of phosphonium cetyl(PEG)10 sulfate liquids have been synthesized and as coating materials Burkholderia cepacia lipase (Lipase PS) through lyophilization process. Tributyl ([2-methoxy]ethoxymethyl)phosphonium ([P444MEM ][C16 (PEG)10 SO4 ]) (PL1) worked best them, PL1-coated PS...

10.1002/biot.201500413 article EN Biotechnology Journal 2015-10-23

Three types of quaternary ammonium salts, tris(diethylamino)cyclopropenium cetyl-PEG10 sulfate (TAC1), N,N,N,N-tetraethylammonium (TEA), and N,N-diethylpiperidinium (PP22), have been prepared evaluated for their activation property Burkholderia cepacia lipase using them as coating materials the enzyme. Among three tested IL-coated enzymes, TAC1-coated PS (TAC1-PS) was especially suitable transesterification 1-(pyridin-2-yl)ethanol, 1-(pyridin-3-yl)ethanol, 1-(pyridin-4-yl)ethanol,...

10.1021/acssuschemeng.7b02607 article EN ACS Sustainable Chemistry & Engineering 2017-08-30

We have developed a semitransparent layer structure that is ideally suited to the laser-incident-side (front-side) recording of rewritable dual-layer Blu-ray Disc (BD-RE). A TiO 2 top film and memory GeTe–Sb Te 3 characterize this structure. The has large refractive index, which works increase transmittance entire more than 50%. It simultaneously increases reflectivity contrast, defined by ( R cry - amo )/( + ), where &gt; ) are reflectivities optical disc in crystalline amorphous parts,...

10.1143/jjap.44.3037 article EN Japanese Journal of Applied Physics 2005-05-01

A rewritable phase-change optical disk providing a large capacity of 100 Gbyte on 120 mm was first demonstrated using the multilayer Blu-ray Disc TM (BD-XL) format. The doubled this compared with that conventional dual-layer achieved firstly by stacking triple recording layers and secondly increasing per layer from 25 to 33.4 at 33.6%. high transmittances 50% (middle layer) 60% (front were thinning Ge–Sb–Te film 7.5 6 nm also Ag-alloy 9 7 nm, respectively. An additional TiO 2 -based formed...

10.1143/jjap.50.062503 article EN Japanese Journal of Applied Physics 2011-06-01

Abstract Objectives Patients with haemoptysis often experience daily physical and mental impairment. Bronchial artery embolisation is among the first-line treatment options used worldwide; however, no evidence exists regarding health-related quality of life (HRQoL) after bronchial embolisation. Therefore, this study aimed to evaluate effects on HRQoL patients haemoptysis. Methods We prospectively enrolled 61 consecutive who visited our hospital from July 2017 August 2018 received for The...

10.1007/s00330-020-07533-x article EN cc-by European Radiology 2021-01-06

Gadoxetic acid is both an extracellular- and hepatocyte-specific contrast agent. Signals from the extracellular space may lower between lesions surrounding hepatic parenchyma. To improve enhancement, we developed intracellular contrast-enhancing fat-saturated T1-weighted gradient-echo nature of sequence (ICE-TIGRE). It incorporates motion-sensitized driven-equilibrium (MSDE) pulse to suppress signals blood flow. We investigated optimal ICE-TIGRE scanning parameters, i.e., order MSDE fat...

10.2463/mrms.tn.2023-0104 article EN cc-by-nc-nd Magnetic Resonance in Medical Sciences 2024-01-01

Abstract Purpose Under-sampled scans with iterative reconstruction and high-frequency preserving transform (Us-IRHF) can increase the acquisition speed without degrading image quality by recovering information from under-sampled data. We investigate clinical applicability of high spatial resolution magnetic resonance cholangiopancreatography (MRCP) images extending scanning time using Us-IRHF. Methods A slit phantom was scanned conventional- (without Us-IRHF), Us-IR- HF), Us-IRHF scanning....

10.1007/s11604-024-01688-z article EN cc-by Japanese Journal of Radiology 2024-11-05

We observed electrical switching phenomena in a phase change material (Ge2Sb2Te5) contact with metallic nanowires of 100 nmφ, which were embedded track-etched polycarbonate membrane by electroplating. While the resistance system did not when applied voltage was 0–1 V, occurred from high-resistance state (HS) to low-resistance (LS) increased 0 V 5 and then decreased V. The maximum current nA. LS 10 times more conductive than HS. A reset operation HS realized using 20 ns pulse Switchings...

10.1143/jjap.41.l1443 article EN Japanese Journal of Applied Physics 2002-12-15
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