A5101890268- Autoimmune Bullous Skin Diseases
- Urticaria and Related Conditions
- Dermatology and Skin Diseases
- Systemic Lupus Erythematosus Research
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Celiac Disease Research and Management
- melanin and skin pigmentation
- Eosinophilic Disorders and Syndromes
- Mast cells and histamine
- Drug-Induced Adverse Reactions
- T-cell and B-cell Immunology
- Allergic Rhinitis and Sensitization
- Systemic Sclerosis and Related Diseases
- Psoriasis: Treatment and Pathogenesis
- Contact Dermatitis and Allergies
- Hair Growth and Disorders
- Autoimmune and Inflammatory Disorders
- Nail Diseases and Treatments
- Inflammatory Myopathies and Dermatomyositis
- Asthma and respiratory diseases
- Dermatologic Treatments and Research
- Genetic and rare skin diseases.
- Platelet Disorders and Treatments
- Cancer and Skin Lesions
- Skin and Cellular Biology Research
University of Florence
2009-2020
University of Genoa
2006
Florence (Netherlands)
2001-2006
University of Milan
2005
Istituto Dermopatico dell'Immacolata
2005
University of Turin
2005
Ospedale Maggiore
2005
Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico
2005
Institute of Dermatology
2004
Azienda Sanitaria di Firenze
2004
Vitiligo is a skin disease that caused by selective destruction of melanocytes and characterized white spots. Melanocytes keratinocytes seem to exhibit functional close relationship, mediated at least in part keratinocyte-derived cytokines, which important for survival activity melanocytic cells. We wanted investigate the hypothesis vitiligo expression epidermal cytokines may be modified compared with normal skin. In 15 patients active, non-segmental vitiligo, biopsies were obtained from...
Background Systemic sclerosis (SSc) and morphoea are connective tissue diseases characterized by fibrosis of the skin. Although to date their pathogenesis has not been clearly defined, it is thought that autoimmunity may play a role in development skin lesions observed both these diseases. As regulatory T cells (Tregs) key modulation immune responses, recently suggested Treg impairment lead autoimmune Objectives To investigate presence Tregs immunomodulatory cytokines, transforming growth...
We have evaluated the incidence of lupus erythematosus (LE)-specific skin disease in 186 patients with LE, seen retrospectively over a 10-year period at our Dermatology Department and determined correlation LE-nonspecific systemic involvement. Chronic cutaneous LE (CCLE) classical discoid lesions (localized, 70%; generalized, 30%) was most common manifestation (72.5%). Subacute (SCLE) represented only 8% (annular-polycyclic type, 73%; papulo-squamous 27%). Acute (ACLE) detected 15% patients:...
Erythema multiforme (EM) and Stevens-Johnson syndrome/toxic epidermal necrolysis (SJS/TEN) are caused by a dysregulation of cellular immunity.To evaluate further the potential role certain cytokines chemokine receptors in cutaneous lesions patients affected EM SJS/TEN to establish whether such diseases polarized preferentially towards T-helper (Th) 1 or Th2 pattern.Biopsy specimens from eight with EM, six three healthy controls were stained for immunohistochemical examination using alkaline...
Vitiligo is a skin disorder characterized by loss of functional melanocytes. Keratinocytes contribute to melanocyte homeostasis, and keratinocyte alteration may play role in dysfunction vitiligo. In particular, the release melanogenic mediators level functioning keratinocytes affect vitiligo epidermis. Keratinocyte-derived involved pigmentation, analysed situ hybridization, epidermal apoptosis, detected TUNEL assay electron microscopy, were evaluated lesional perilesional biopsies from 15...
Drug-induced subacute cutaneous lupus erythematosus (DI-SCLE) is a variant with predominant skin involvement temporally related to drug exposure and resolving after discontinuation. It usually presents annular polycyclic or papulosquamous eruptions on sun-exposed shows serum anti-Ro/SSA antibodies.To address the question whether DI-SCLE differs significantly from idiopathic SCLE by virtue of clinical features.Ninety patients seen in our departments 2001 2010 were reviewed. Eleven them...
Abstract Background Although regulatory T cells (Tregs) are affected in several autoimmune skin diseases, only two studies have been performed patients with bullous pemphigoid ( BP ) contrasting results. Objective To characterize Tregs and to determine the serum levels of cytokines . Methods In lesional skin, immunohistochemistry confocal microscopy were for CD 4 + , 25 forkhead/winged helix transcription factor FOXP 3) transforming growth TGF )‐β interleukin IL )‐10 cells. addition, number...
Skin tests with autologous serum elicit an immediate wheal-and-flare response in about 30-50% of chronic idiopathic urticaria subjects, suggesting that autoimmune mechanism might be involved the pathogenesis this disease. The aim present work, involving 68 subjects urticaria, was to distinguish between serum-positive and serum-negative cases highlight clinical differences two groups on basis Breneman scale score. We also tried correlate finding a positive skin test other diatheses or fully...
There have been only two reports on immunophenotypic characterization in the cutaneous lesions of dermatomyositis (DM) that emphasize importance infiltrating CD4+ T lymphocytes.To characterize immunophenotype cells infiltrate lesional skin DM and to evaluate possible T-helper (Th) polarization Th1/Th2 through detection specific cytokines, chemokine receptors markers cellular activation.Skin biopsy specimens derived from pathognomonic (Gottron's papules Gottron's sign) eight patients with...
Background: Atopic dermatitis (AD) is common in children industrialized countries. Only one large population study on its prevalence has been conducted Italy, based self‐report questionnaire. The present was designed to estimate the of AD schoolchildren Italy by dermatologists’ assessment and UK Working Party criteria, investigate associated symptoms factors. Methods: Cross‐sectional survey a random sample 9‐year‐old from seven Italian cities. Children were examined experienced...
Pseudopelade of Brocq (PB) is a permanent progressive scarring alopecia characterized by numerous alopecic patches localized only in the scalp, that tend to coalesce into larger, irregular plaques with policyclic borders. PB can be considered either final atrophic stage several disorders such as lichen planus pilaris (LPP) and discoid lupus erythematosus (DLE) (secondary PB) or an autonomous disease (primary PB). The aim this study was assess incidence primary vs. secondary combined...
In approximately one-third of patients with chronic idiopathic urticaria (CIU), autoantibodies against the high-affinity IgE receptor and/ or can be detected and a wheal-and-flare response provoked by intradermal injection autologous serum (ASST). this study we aimed to further characterize inflammatory observed in subgroup CIU positive ASST serum-evoked histamine-release vitro from basophils comparison unaffected skin healthy donors. An immunohistochemical analysis infiltrating cells (CD4,...
Erythema multiforme (EM) and Stevens-Johnson syndrome (SJS)/toxic epidermal necrolysis (TEN) are determined by a dysregulation of cellular immunity.To evaluate the effector role immunity involvement CD40/CD40 ligand (CD40L) system in pathogenesis EM SJS/TEN.Biopsy specimens from eight patients with six SJS/TEN were stained for immunohistochemical examination using alkaline phosphatase/antialkaline phosphatase method. The monoclonal antibodies used included those to CD1a, CD4, CD8, CD40,...
Background While many studies have demonstrated the efficacy and safety of tacrolimus ointment in treatment atopic dermatitis (AD), only a few investigated effects on inflammatory cells their cytokine gene expression patients with AD. Objectives To characterize further immunophenotype infiltrating production certain cytokines before after topical hydrocortisone butyrate. Methods Nine adult moderate to severe AD were treated ointment, while seven control butyrate ointment. We performed...
Scarring alopecia is a very frequent feature of chronic discoid lupus erythematosus (DLE). So far in the literature, only clinic-pathologic features or histopathologic-immunopathologic traits DLE scarring (DLESA) have been reported. We describe most significant clinical morphology, histopathology, serum and tissue immunopathology 36 DLESA patients (41.9% all our patients). Clinically, 33.3% presented single lesion 52.7% multiple lesions alopecia, while 13.8% exhibited picture resembling...