A5019267824- Autoimmune Bullous Skin Diseases
- Urticaria and Related Conditions
- Dermatology and Skin Diseases
- Psoriasis: Treatment and Pathogenesis
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Drug-Induced Adverse Reactions
- Inflammatory Myopathies and Dermatomyositis
- T-cell and B-cell Immunology
- Contact Dermatitis and Allergies
- Mast cells and histamine
- Eosinophilic Disorders and Syndromes
- Autoimmune and Inflammatory Disorders
- Dermatological and Skeletal Disorders
- Hidradenitis Suppurativa and Treatments
- Asthma and respiratory diseases
- Systemic Sclerosis and Related Diseases
- Skin and Cellular Biology Research
- Systemic Lupus Erythematosus Research
- Allergic Rhinitis and Sensitization
- Monoclonal and Polyclonal Antibodies Research
- Celiac Disease Research and Management
- Chemotherapy-related skin toxicity
- Immune Cell Function and Interaction
- Skin Diseases and Diabetes
- Melanoma and MAPK Pathways
Azienda Usl Toscana Centro
2022-2025
University of Florence
2012-2025
Istituto Dermopatico dell'Immacolata
2005
University of Turin
2005
Ospedale Maggiore
2005
University of Milan
2005
Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico
2005
Institute of Dermatology
2004
Florence (Netherlands)
2001
Background Systemic sclerosis (SSc) and morphoea are connective tissue diseases characterized by fibrosis of the skin. Although to date their pathogenesis has not been clearly defined, it is thought that autoimmunity may play a role in development skin lesions observed both these diseases. As regulatory T cells (Tregs) key modulation immune responses, recently suggested Treg impairment lead autoimmune Objectives To investigate presence Tregs immunomodulatory cytokines, transforming growth...
Curcumin is a complementary therapy that may be helpful for the treatment of psoriasis due to its anti-inflammatory, antiangiogenic, antioxidant, and antiproliferative effects. In present study we performed randomized, double-blind, placebo-controlled clinical trial assess effectiveness bioavailable oral curcumin in psoriasis. Sixty-three patients with mild-to-moderate vulgaris (PASI < 10) were randomly divided into two groups treated topical steroids Meriva, commercially available...
The association between psoriasis and streptococcal infection has been widely explored in both children adults. However, the exact impact of Streptococcus pharyngeal on course is not fully comprehended. This study investigated effectiveness systemic antibiotic therapy conjunction with standard topical treatment for psoriatic patients concomitant throat infection. research involved 115 mild-to-moderate psoriasis, clinically assessed using Psoriasis Area Severity Index (PASI). Patients active...
Erythema multiforme (EM) and Stevens-Johnson syndrome/toxic epidermal necrolysis (SJS/TEN) are caused by a dysregulation of cellular immunity.To evaluate further the potential role certain cytokines chemokine receptors in cutaneous lesions patients affected EM SJS/TEN to establish whether such diseases polarized preferentially towards T-helper (Th) 1 or Th2 pattern.Biopsy specimens from eight with EM, six three healthy controls were stained for immunohistochemical examination using alkaline...
Abstract Background Although regulatory T cells (Tregs) are affected in several autoimmune skin diseases, only two studies have been performed patients with bullous pemphigoid ( BP ) contrasting results. Objective To characterize Tregs and to determine the serum levels of cytokines . Methods In lesional skin, immunohistochemistry confocal microscopy were for CD 4 + , 25 forkhead/winged helix transcription factor FOXP 3) transforming growth TGF )‐β interleukin IL )‐10 cells. addition, number...
Skin tests with autologous serum elicit an immediate wheal-and-flare response in about 30-50% of chronic idiopathic urticaria subjects, suggesting that autoimmune mechanism might be involved the pathogenesis this disease. The aim present work, involving 68 subjects urticaria, was to distinguish between serum-positive and serum-negative cases highlight clinical differences two groups on basis Breneman scale score. We also tried correlate finding a positive skin test other diatheses or fully...
There have been only two reports on immunophenotypic characterization in the cutaneous lesions of dermatomyositis (DM) that emphasize importance infiltrating CD4+ T lymphocytes.To characterize immunophenotype cells infiltrate lesional skin DM and to evaluate possible T-helper (Th) polarization Th1/Th2 through detection specific cytokines, chemokine receptors markers cellular activation.Skin biopsy specimens derived from pathognomonic (Gottron's papules Gottron's sign) eight patients with...
Folliculitis decalvans (FD) is a rare variant of primary cicatricial alopecia, for which the etiopathogenesis remains unclear. Our purpose was to evaluate whether certain immunologic mechanisms might have significant role in pathogenesis FD. Lesional scalp biopsy specimens from 7 patients with FD, lichen planopilaris, and 4 alopecia areata were studied immunohistochemically by using monoclonal antibodies CD1a, CD3, CD4, CD8, CD20, CD25, HLA-DR, interleukin (IL)-1beta, IL-4, IL-8, interferon...
Pyoderma gangrenosum (PG) is a rare, immune-mediated skin disease classified into the group of neutrophilic dermatoses. Although number studies confirmed central role innate immunity, only few have investigated possible contributing acquired immunity. In particular, no reports concerning T helper type 1 (Th1) and Th2 cells are available as yet. Therefore, 15 patients with PG, five Sweet's syndrome (SS) nine specimens from healthy controls (HC) were investigated, evaluating expression...
In approximately one-third of patients with chronic idiopathic urticaria (CIU), autoantibodies against the high-affinity IgE receptor and/ or can be detected and a wheal-and-flare response provoked by intradermal injection autologous serum (ASST). this study we aimed to further characterize inflammatory observed in subgroup CIU positive ASST serum-evoked histamine-release vitro from basophils comparison unaffected skin healthy donors. An immunohistochemical analysis infiltrating cells (CD4,...
Erythema multiforme (EM) and Stevens-Johnson syndrome (SJS)/toxic epidermal necrolysis (TEN) are determined by a dysregulation of cellular immunity.To evaluate the effector role immunity involvement CD40/CD40 ligand (CD40L) system in pathogenesis EM SJS/TEN.Biopsy specimens from eight patients with six SJS/TEN were stained for immunohistochemical examination using alkaline phosphatase/antialkaline phosphatase method. The monoclonal antibodies used included those to CD1a, CD4, CD8, CD40,...
Background While many studies have demonstrated the efficacy and safety of tacrolimus ointment in treatment atopic dermatitis (AD), only a few investigated effects on inflammatory cells their cytokine gene expression patients with AD. Objectives To characterize further immunophenotype infiltrating production certain cytokines before after topical hydrocortisone butyrate. Methods Nine adult moderate to severe AD were treated ointment, while seven control butyrate ointment. We performed...
Background. Alterations of Toll‐like receptors (TLRs) seem to play a role in susceptibility atopic dermatitis (AD). Aim. To investigate the expression TLRs moderate severe chronic AD adults before and after 3‐week treatment with 0.1% tacrolimus ointment, compared topical hydrocortisone‐17‐butyrate. Methods. In total, 21 adult patients were enrolled: 11 given ointment 10 hydrocortisone butyrate; further 6 healthy formed control group. The clinical efficacy was assessed using SCORing Atopic...
Psoriasis is a chronic and relapsing inflammatory skin disease, clinically characterized by erythematous scaly plaques. Treatment approach mainly driven disease severity, though several factors should be considered in order to identify the optimal therapeutic choice. Mild psoriasis may treated with wide array of topical agents including corticosteroids, vitamin D analogs, keratolytics, calcipotriol/betamethasone propionate compound. Because guidelines not provide practical indications...
Some antihistamines are capable of reducing levels adhesion molecules in wealing tissues patients with chronic urticaria (CU).To determine if 6 weeks therapy levocetirizine 5 mg once daily would also induce any decrease serum intercellular molecule-1, vascular cell endothelial leucocyte molecule-1 (ELAM-1) or P-selectin subjects CU and autoimmune urticaria.Thirty-six (18 positive 18 negative autologous skin test) were studied, together 10 control healthy subjects. All received daily. Serum...