A5004091362- Prostate Cancer Treatment and Research
- PARP inhibition in cancer therapy
- Science, Research, and Medicine
- Cancer Genomics and Diagnostics
- Computational Drug Discovery Methods
- Glutathione Transferases and Polymorphisms
- Radiopharmaceutical Chemistry and Applications
- RNA and protein synthesis mechanisms
- Microbial Natural Products and Biosynthesis
- Bioinformatics and Genomic Networks
- Mesenchymal stem cell research
- Single-cell and spatial transcriptomics
- 14-3-3 protein interactions
- Genomics and Phylogenetic Studies
- Optimization and Variational Analysis
- Malaria Research and Control
- Advanced Optimization Algorithms Research
- Cardiac Fibrosis and Remodeling
- Advanced Polymer Synthesis and Characterization
- Carcinogens and Genotoxicity Assessment
- DNA and Nucleic Acid Chemistry
- Endometrial and Cervical Cancer Treatments
- Cancer Risks and Factors
- Lipid metabolism and disorders
- Sparse and Compressive Sensing Techniques
Soochow University
2025
First Affiliated Hospital of Soochow University
2025
Affiliated Hospital of Youjiang Medical University for Nationalities
2024
Beijing YouAn Hospital
2024
Capital Medical University
2024
University of Minnesota
2019-2023
Twin Cities Orthopedics
2023
Dana-Farber Cancer Institute
2019-2021
Harvard University
2014-2021
University of Minnesota Medical Center
2019-2020
We describe the assembly and annotation of a chemogenomic set protein kinase inhibitors as an open science resource for studying biology. The only includes that show potent inhibition narrow spectrum activity when screened across large panel biochemical assays. Currently, contains 187 cover 215 human kinases. (KCGS), current Version 1.0, is most highly annotated selective available to researchers use in cell-based screens.
Altered BM hematopoiesis and immune suppression are hallmarks of myelodysplastic syndrome (MDS). While the microenvironment influences malignant hematopoiesis, mechanism leading to MDS-associated is unknown. We tested whether mesenchymal stromal cells (MSCs) contribute this process. Here, we developed a model study cultured MSCs from patients with MDS (MDS-MSCs) compared those aged-matched normal controls for regulation function. MDS-MSCs healthy donor (HD-MSCs) exhibited similar in vitro...
Frequent exposure to chemicals in the environment, diet, and endogenous electrophiles leads chemical modification of DNA formation adducts. Some adducts can induce mutations during cell division and, when occurring critical regions genome, lead onset disease, including cancer. The targeted analysis over past 30 years has revealed that human genome contains many types damages. However, a long-standing limitation conducting adduct measurements been inability screen for total complement derived...
In patients with metastatic prostate cancer (mPC), ATM and BRCA2 mutations dictate differences in PARPi inhibitor response other therapies. We interrogated the molecular features of ATM- BRCA2-mutated mPC to explain divergent clinical outcomes inform future treatment decisions. examined a novel set 1,187 mPCs after excluding microsatellite-instable (MSI) tumors. stratified these based on (n = 88) or 98) mutations. As control groups, 12 homologous recombination repair (HRR) genes were...
Secretomes produced by mesenchymal stromal cells (MSCs) were considered to be therapeutic potential. However, harvesting enough primary MSCs from tissue was time-consuming and costly, which impeded the application of secretomes. This study immortalize compare secretomes profile immortalized original MSCs. Human dental follicle (DFCs) isolated using pMPH86. The secretome DFCs (iDFCs) investigated compared iTRAQ labeling combined with mass spectrometry (MS) quantitative proteomics. MS data...
Recent single-cell transcriptomic studies revealed new insights into cell-type heterogeneities in cellular microenvironments unavailable from bulk studies. A significant drawback of currently available algorithms is the need to use empirical parameters or rely on indirect quality measures estimate degree complexity, i.e., number subgroups present sample. We fill this gap with a data analysis procedure allowing for unambiguous assessments depth heterogeneity subclonal compositions supported...
To evaluate the insulin resistance in patients with menopause who were newly diagnosed endometrial cancer and its association disease development.
Due to the complex pathogenesis, molecular mechanism of nonalcoholic steatohepatitis (NASH) remains unclear. In this study, we aimed reveal comprehensive metabolic and signaling pathways in occurrence NASH.
Abstract We describe the assembly and annotation of a chemogenomic set protein kinase inhibitors as an open science resource for studying biology. The only includes that show potent inhibition narrow spectrum activity when screened across large panel biochemical assays. Currently, contains 187 cover 215 human kinases. (KCGS) is most highly annotated selective available to researchers use in cell-based screens.
Aim: Analysis of large datasets has become integral to biological studies due the advent high throughput technologies such as next generation sequencing. Techniques for analyzing these are normally developed by bioinformaticists and statisticians, with input from biologists. Frequently, end-user does not have training or knowledge make informed decisions on parameter settings required implement analyses pipelines. Instead, relies “default” present within software packages, consultations...
Objectives: To explore the relationship between adiponectin (APN) and bone mineral density in this Zhuang ethnic group, thus providing a basis underpinning prevention treatment of osteoporosis (OP). Methods: women over 50 years old Guangxi Autonomous Region were included study. The broadband ultrasound attenuation (BUA) was adopted as reference to calculate T value. Quantitative ultrasonic measured on right. Body composition measuring instrument used measure weight, fat, muscle mass. Plasma...
<p>Overall survival of ATM, BRCA2 mutant, and HRDother mPCs.</p>
<div>Abstract<p>Purpose: In metastatic prostate cancer (mPC) patients, <i>ATM</i> and <i>BRCA2</i> mutations dictate differences in PARP inhibitor response other therapies. We interrogated the molecular features of <i>ATM-</i> <i>BRCA2-</i>mutated mPC to explain divergent clinical outcomes inform future treatment decisions. Experimental design: examined a novel set 1187 mPCs after excluding microsatellite unstable (MSI) tumors....
<p>AR activities and NEPC signatures in ATM- BRCA2- mutated tumors.</p>