A5077668887- Crystallization and Solubility Studies
- X-ray Diffraction in Crystallography
- Petroleum Processing and Analysis
- Microfluidic and Capillary Electrophoresis Applications
- Analytical Chemistry and Sensors
- Hydrocarbon exploration and reservoir analysis
- Enhanced Oil Recovery Techniques
- Porphyrin and Phthalocyanine Chemistry
- Multicomponent Synthesis of Heterocycles
- Innovative Microfluidic and Catalytic Techniques Innovation
- Oxidative Organic Chemistry Reactions
- Crystallography and molecular interactions
- Fish Ecology and Management Studies
- Ion channel regulation and function
- Electrowetting and Microfluidic Technologies
- Traditional and Medicinal Uses of Annonaceae
- Genomics, phytochemicals, and oxidative stress
- CRISPR and Genetic Engineering
- Inorganic and Organometallic Chemistry
- Alkaloids: synthesis and pharmacology
- Chemical synthesis and alkaloids
- Dendrimers and Hyperbranched Polymers
- Electrochemical Analysis and Applications
- Microfluidic and Bio-sensing Technologies
- Epigenetics and DNA Methylation
University of Alberta
2015-2023
University of Kansas
2013-2015
γ-Lactam derivatives with multiple contiguous stereogenic carbon centers are ubiquitous in physiologically active compounds. The development of straightforward and reliable synthetic routes to such chiral structural motifs a stereocontrolled manner should thus be importance. Herein, we report strategy construct polycyclic γ-lactam that contain more than two an enantioselective as well atom-economic manner. Moreover, have achieved the first synthesis strigolactam derivative GR-24, racemic...
The Hansen solubility parameters (HSPs) of asphaltene model compounds were determined experimentally via testing. For the test, we synthesized various archipelago- and continental-type molecule compounds: 5 steroid-derived naphthoquinoline compounds; 14 phenanthrene/pyrene-derived 2 nickel porphyrins; 1 was an alkyl hexabenzocoronene molecule. Some them contain nitrogen as quinoline or porphyrin structure, oxygen furan sulfur thiophene structure. Using sphere method, HSPs δd, δp, δh...
An all-PDMS on-line microdialysis-microchip electrophoresis with on-chip derivatization and electrophoretic separation for near real-time monitoring of primary amine-containing analytes is described. Each part the chip was optimized separately, effect each components on temporal resolution, lag time, efficiency device determined. Aspartate glutamate were employed as test analytes. Derivatization accomplished naphthalene-2,3,-dicarboxyaldehyde/cyanide (NDA/CN(-)), performed using a 15-cm...
Abstract The development of an all‐glass separation‐based sensor using microdialysis coupled to microchip electrophoresis with amperometric detection is described. system includes a flow‐gated interface inject discrete sample plugs from the perfusate into system. Electrochemical was accomplished platinum electrode in in‐channel configuration wireless electrically isolated potentiostat. To facilitate bonding around electrode, fabrication process employed that produced working and reference...
Lab-on-a-sheep: on-animal sensor using microdialysis coupled to microchip electrophoresis with electrochemical detection.
A multicomponent cyclocondensation reaction between 2-aminoanthracene, aromatic aldehydes, and 5-α-cholestan-3-one has been used to synthesize model asphaltene compounds. The active catalyst for this identified as hydriodic acid, which is formed in situ from the of iodine with water, while not a under anhydrous conditions. products, contain tetrahydro[4]helicene moiety, are optically active, stereochemical characteristics have examined by VT-NMR VT-CD spectroscopies, well X-ray crystallography.
In this paper, we report a highly efficient, scalable approach to the total synthesis of conformationally unrestricted, electronically isolated arrays alkyl-tethered polycyclic aromatic chromophores. This new class modular molecules consists "islands" comprising significant structural fragments present in unrefined heavy petroleum, tethered together by short saturated alkyl chains, as represented "archipelago model" asphaltene structure. The most branched archipelago compounds reported here...
Disaggregation of asphaltene aggregate in solution is investigated using ultrasmall-, small-, and wide-angle scattering X-rays up to 300 °C under isobaric conditions. Wide-angle profiles indicate that the longer range structure aggregates toluene collapses around 150 °C. A further increase temperature °C, however, leads a slight reversion aggregated state. This specific behavior discussed terms transition from solid melted state 200 corresponding change affinity indices Hansen solubility...
Abstract Catalytic iodine in the presence of water acts indirectly as a source Brønsted acid and, concurrently, generates iodonium ion and hydrogen peroxide, which mediate final oxidative aromatization step multicomponent cyclocondensation an aromatic amine two aliphatic aldehyde compounds. The cycle this related iodine‐catalyzed reactions is seldom discussed, generally unoptimized, rarely investigated detail. This work establishes that independent catalytic cycles (H + I − /I ) drive such...