A5081259408- Bone Metabolism and Diseases
- MicroRNA in disease regulation
- Muscle Physiology and Disorders
- Bone health and treatments
- Adipose Tissue and Metabolism
- Osteoarthritis Treatment and Mechanisms
- SARS-CoV-2 and COVID-19 Research
- Animal Virus Infections Studies
- Circular RNAs in diseases
- Bone and Joint Diseases
- Immunotherapy and Immune Responses
- Cancer-related molecular mechanisms research
- interferon and immune responses
- Connective tissue disorders research
- Neurogenesis and neuroplasticity mechanisms
- Retinoids in leukemia and cellular processes
- RNA Interference and Gene Delivery
- COVID-19 Clinical Research Studies
- Muscle metabolism and nutrition
- Biochemical effects in animals
- RNA modifications and cancer
- Chemokine receptors and signaling
- Protease and Inhibitor Mechanisms
- Zebrafish Biomedical Research Applications
- Hemoglobinopathies and Related Disorders
University of Verona
2021-2025
Azienda Ospedaliera Universitaria Integrata Verona
2021
Overexpression of the Runt-related transcription factor 2 (RUNX2) has been reported in several cancer types, and C-X-C motif chemokine receptor 4 (CXCR4) an important role tumour progression. However, interplay between CXCR4 RUNX2 melanoma cells remains poorly understood. In present study, we used a knockout (RUNX2-KO) vitro model to assess influence on protein levels along with its effects markers associated cell invasion autophagy. Osteotropism was assessed using 3D microfluidic model....
Aging is associated with the accumulation of cellular damage due to oxidative stress and chronic low-grade inflammation, collectively referred as "inflammaging". This contributes functional decline in various tissues, including brain skeletal system, which closely interplay. Mesenchymal stem cells (MSCs), known for their regenerative potential ability modulate offer a promising therapeutic approach counteract aging-related declines. In this study, we investigated effects homotaurine (a small...
The antibody response to SARS-CoV-2 mRNA vaccines in individuals with waning immunity generated by a previous infection, as well the patterns of IgA and IgM responses previously infected naïve are still poorly understood.
Abstract Background Methylsulfonylmethane (MSM) is a nutraceutical compound which has been indicated to counteract osteoarthritis, cartilage degenerative disorder. In addition, MSM also shown increase osteoblast differentiation. So far, few studies have investigated role in the differentiation of mesenchymal stem cells (MSCs), and no study performed evaluate its overall effects on both osteogenic chondrogenic These two mutually regulated processes share same progenitor cells. Methods...
Abstract The ubiquitin‐proteasome system (UPS) plays an important role in maintaining cellular homeostasis by degrading a multitude of key regulatory proteins. FBXW11, also known as b‐TrCP2, belongs to the F‐box family, which targets proteins be degraded UPS. Transcription factors or associated with cell cycle can modulated may stimulate inhibit proliferation. Although FBXW11 has been investigated embryogenesis and cancer, its expression not evaluated osteogenic cells. With aim explore...
Stem cells functions are regulated by different factors and non-conding RNAs, such as microRNA. MiRNAsplay an important role in modulating the expression of genes involved commitment differentiation progenitor cells. MiRNAs post transcriptional regulators which may be modulated physical exercise. MiRNAs, regulating signaling pathways, play myogenesis well muscle activity. quantification considered for evaluating performance or recovery. With aim to identify specific miRNAs potentially...
RUNX2 and SOX9 are two pivotal transcriptional regulators of chondrogenesis. It has been demonstrated that physically interact; transactivation may be inhibited by SOX9. In addition, exerts reciprocal inhibition on transactivity. Epigenetic control gene expression plays a major role in the alternative differentiation fates stem cells; particular, it reported can promote miRNA (miR)-204. Our aim was therefore to investigate miR-204-5p during chondrogenesis identify relationship between this...
Flavonoids may modulate the bone formation process. Among flavonoids, fisetin is known to counteract tumor growth, osteoarthritis, and rheumatoid arthritis. In addition, prevents inflammation-induced loss. order evaluate its favorable use in osteogenesis, we assayed supplementation both vitro vivo models gathered information on nanoparticle-mediated delivery of a microfluidic system. Real-time RT-PCR, Western blotting, nanoparticle synthesis were performed effects vitro, zebrafish model, ex...
Sickle cell disease (SCD) is a genetic disorder of hemoglobin, leading to chronic hemolytic anemia and multiple organ damage. Among complications, sickle bone (SBD) has very high prevalence, resulting in long-term disability, pain fractures. Here, we evaluated the effects ω-3 (fish oil-based, FD)-enriched diet vs. ω-6 (soybean SD)- supplementation on murine SBD. We exposed SCD mice recurrent hypoxia/reoxygenation (rec H/R), consolidated model for In rec H/R SS mice, FD improves...
Cleidocranial dysplasia (CCD), a dominantly inherited skeletal disease, is characterized by variable phenotype ranging from dental alterations to severe defects. Either de novo or mutations in the RUNX2 gene have been identified most CCD patients. Transcription factor RUNX2, osteogenic master gene, plays central role commitment of mesenchymal stem cells osteoblast lineage. With aim analyse effects patients, we investigated expression and potential two patients' cells. In addition, with...
Abstract We profiled antibody responses in a cohort of recipients the BTN162b2 mRNA vaccine who were either immunologically naïve (n=50) or had been previously infected with SARS-CoV-2 (n=51). Of infected, 25 and 26 during first second pandemic waves Italy, respectively; majority those from wave corresponding waning immunity low to undetectable levels anti-S antibodies anti-N antibodies. observed that spike-specific IgG pseudovirus neutralization titers rapidly recalled by single dose higher...
Abstract Background NorthCape4000 (NC4000) is the most participated ultra-endurance cycling race. Eight healthy male Caucasian amateur cyclists were evaluated: (a) before starting preparation period; (b) in week preceding NC4000 (after training period); (c) after race, with aim to identify effects of ultra-cycling on body composition, aerobic capacity and biochemical parameters as well differentiation progenitor cells. Methods Bioelectrical impedance analysis (BIA) dual energy x-ray...
The finding of molecules associated with aging is important for the prevention chronic degenerative diseases and longevity strategies. MicroRNAs (miRNAs) are post-transcriptional regulators involved in many biological processes miR-146b-5p has been shown to be different diseases. However, modulation not evaluated mesenchymal stem cells (MSCs) commitment or during aging. Therefore, differentiation as well maturation zebrafish model were analyzed. In addition, circulating was human subjects at...