A5100457054- Immunodeficiency and Autoimmune Disorders
- Immune cells in cancer
- Platelet Disorders and Treatments
- Monoclonal and Polyclonal Antibodies Research
- Immunotherapy and Immune Responses
- Autoimmune Bullous Skin Diseases
- Blood disorders and treatments
- Pancreatic function and diabetes
- TGF-β signaling in diseases
- Peptidase Inhibition and Analysis
- Protease and Inhibitor Mechanisms
- Cancer Immunotherapy and Biomarkers
- Peripheral Neuropathies and Disorders
- Cytokine Signaling Pathways and Interactions
- Chronic Lymphocytic Leukemia Research
- Chemokine receptors and signaling
- Cell Adhesion Molecules Research
- Blood Coagulation and Thrombosis Mechanisms
- Pelvic and Acetabular Injuries
- Pharmacogenetics and Drug Metabolism
- Complement system in diseases
- Immune Response and Inflammation
- Pharmaceutical studies and practices
- Multiple Myeloma Research and Treatments
- Immune Cell Function and Interaction
Takeda (United States)
2018-2025
State Key Laboratory of Medical Neurobiology
2024-2025
Fudan University
2024-2025
Xi'an Jiaotong University
2024
Sun Yat-sen University
2024
Sun Yat-sen University Cancer Center
2024
Yangpu Hospital of Tongji University
2023-2024
Center for Cancer Research
2010-2023
National Cancer Institute
2010-2023
Baoding People's Hospital
2020-2023
The mechanisms by which a primary tumor affects selected distant organ before cell arrival remain to be elucidated. This report shows that Gr-1+CD11b+ cells are significantly increased in lungs of mice bearing mammary adenocarcinomas arrival. In the premetastatic lungs, these immature myeloid decrease IFN-gamma production and increase proinflammatory cytokines. addition, they produce large quantities matrix metalloproteinase 9 (MMP9) promote vascular remodeling. Deletion MMP9 normalizes...
Abstract Purpose: To develop an adaptable gene-based vector that will confer immune cell specificity to various cancer types. Experimental Design: Human and mouse T cells were genetically engineered express a chimeric antigen receptor (CAR) binds fluorescein isothiocyanate (FITC) molecule, termed anti-FITC CAR cells. Various antibodies (Ab) currently in clinical use including cetuximab (Ctx), trastuzumab (Her2), rituximab (Rtx) conjugated with FITC tested for their ability bind tumor cells,...
Depsipeptide (FR901228) is a bicyclic peptide isolated from Chromobacterium violaceum that has demonstrated potent in vitro cytotoxic activity against human tumor cell lines and vivo efficacy xenografts. The primary mechanism of action through inhibition histone deacetylase. Initial development was halted due to significant cardiac toxicity. Subsequent studies performed at the National Cancer Institute administration without cardiotoxicity possible by varying schedule administration. A phase...
Alemtuzumab, a humanized anti-CD52 monoclonal antibody, is approved for treatment of relapsing multiple sclerosis (MS). In the Phase II/III trials, patients received 12 or 24 mg/day alemtuzumab in two courses (5 days course 1 and 3 2), months apart. Serum concentrations peaked on last day dosing each mostly fell below limit quantitation by 30. Alemtuzumab rapidly depleted circulating T B lymphocytes, with lowest observed values occurring within days. Lymphocytes repopulated over time, cell...
Abstract Dupilumab is a fully human monoclonal antibody directed against the interleukin (IL)‐4 receptor α subunit (IL‐4Rα) of IL‐4 heterodimeric type I and II receptors that mediate IL‐4/IL‐13 signaling through this pathway. Blockade these broadly suppresses 2 inflammation associated with atopic/allergic diseases, including atopic dermatitis asthma. Six phase 1 studies investigated pharmacokinetics, pharmacodynamics, safety, tolerability dupilumab in healthy subjects. Two randomized,...
ADVANCE-CIDP 1 evaluated facilitated subcutaneous immunoglobulin (fSCIG; human G 10% with recombinant hyaluronidase) efficacy and safety in preventing chronic inflammatory demyelinating polyradiculoneuropathy (CIDP) relapse.ADVANCE-CIDP was a phase 3, double-blind, placebo-controlled trial conducted at 54 sites 21 countries. Eligible adults had definite or probable CIDP adjusted Inflammatory Neuropathy Cause Treatment (INCAT) disability scores of 0-7 (inclusive), received stable intravenous...
Abstract Toll-like receptors (TLR) are expressed by a variety of cancers, including melanoma, but their functional contributions in cancer cells uncertain. To approach this question, we evaluated the effects stimulating or inhibiting TLR/IL-1 receptor-associated kinases IRAK-1 and IRAK-4 melanoma where functions largely unexplored. TLRs TLR-related proteins were variably cell lines, with 42% expressing activated phospho-IRAK-1 constitutively 85% high levels phospho-IRAK-4 absence TLR...
One great challenge in our understanding of TGF-β cancer biology and the successful application TGF-β-targeted therapy is that works as both a tumor suppressor promoter. The underlying mechanisms for its functional change remain to be elucidated. Using 4T1 mammary model shares many characteristics with human breast cancer, particularly ability spontaneously metastasize lungs, we demonstrate Gr-1+CD11b+ cells or myeloid derived are important mediators regulation progression. Depletion...
In the present study, maize starch (MS), potato (PS), high-amylose (HAMS), and wheat (WS) were deep-fried in soybean oil that was continuously heated for 40 h under 180 °C. The thermodynamic pasting properties of samples determined. results suggested starch–lipid complexes formed with extension frying oils’ usage; however, their number not dependent on life cycle. Importantly, revealed following strength intermolecular force samples: PS > MS HAMS WS. XRD FTIR analysis confirmed formation...
This study aimed to systematically explore the chemical constituents of D. nobile and its hypoglycemic effect by UPLC-ESI-Q-Orbitrap, network pharmacology in vivo experiment. The were qualitatively analyzed, compounds quickly identified. Network pharmacological analysis molecular docking technique applied assist elucidation mechanisms nobile. A type 2 diabetic mellitus (T2DM) rat model was established using HFD STZ method for experimental verification, these T2DM rats treated with extract...
Objective This study was designed to examine the prevalence of unilateral and bilateral diagonal earlobe creases (DELCs) with respect diagnosis coronary heart disease (CHD). Methods A total 558 consecutive participants (402 males 156 females) aged 36–91 years who underwent angiography were enrolled in this study. The classified as being without a DELC, having DELC DELCs; either or DELCs defined DELCs. Significant CHD at least one major vessel >50% stenosis, atherosclerosis severity using...
This open-label drug-drug interaction study assessed whether blockade by dupilumab of interleukin (IL)-4 and IL-13 signaling affects the pharmacokinetics drugs metabolized cytochrome P450 (CYP450) enzymes. The five CYP450 substrates given orally (midazolam, omeprazole, S-warfarin, caffeine, metoprolol, CYP3A, CYP2C19, CYP2C9, CYP1A2, CYP2D6, respectively) were evaluated before 28 days after initiation treatment (subcutaneous 300 mg weekly) in 14 patients with moderate-to-severe atopic...
Physical activity (PA) is generally encouraged for the treatment of osteoporosis. However, epidemiological statistics on level physical required bone health are scarce. The purpose this research was to analyze association between PA and total spine mineral density (BMD) in postmenopausal women.The study included women aged ≥ 50 from National Health Nutrition Examination Survey. metabolic equivalent (MET), weekly frequency, duration each were used calculate PA. Furthermore, correlations BMD...
Objective Limited Mendelian randomization (MR) studies have assessed the causal relationship between serum uric acid levels and diabetes risk. Here we investigated causality concentration risk in Chinese population. Research design methods The observational analysis, based on Dongfeng-Tongji prospective cohort (n=15 195) tested association of with incident In instrumental variable examined genetic score (GRS) case-control (2539 cases 4595 controls) via MR analysis. Results During a mean (SD)...
Abstract Purpose To investigate the efficacy, safety, tolerability, and serum IgG trough levels of hyaluronidase-facilitated subcutaneous immunoglobulin (fSCIG) 10% in US pediatric patients with primary immunodeficiency diseases (PIDDs). Methods This phase 3, open-label, prospective study (NCT03277313) was conducted at 17 centers. Eligible aged 2 to < 16 years had PIDDs received G (IgG) a consistent dose for ≥ 3 months before screening. Participants fSCIG via ramp-up up 6 weeks (Epoch 1),...
Varied causative and risk factors can lead to cardiac dysfunction. Cardiac dysfunction often evolves into heart failure by remodeling due autonomic nervous system disturbance neurohumoral abnormalities, even if the detriment are removed. Renal sympathetic nerve activity plays a pivotal regulatory role in mechanisms. The present study was designed determine therapeutic effects of renal denervation (RSD) on dysfunction, fibrosis, response transverse aortic constriction (TAC) rats with chronic...
To assess the effect of serum inorganic phosphate (Pi) on prognosis patients with sepsis. A retrospective analysis sepsis selected from Medical Information Mart for Intensive Care (MIMIC)-IV database was performed. Sepsis diagnosed according to Third International Consensus Definition and septic shock (Sepsis-3). The time-weighted values Pi measurements within first 24 h were analyzed. association between in-hospital mortality evaluated a generalized linear model (log-binomial model). 11,658...
ABSTRACT Background ADVANCE‐CIDP IVIG evaluated the efficacy and safety of immune globulin infusion (human) 10% solution (IVIG 10%; GAMMAGARD LIQUID, also known as Kiovig) in chronic inflammatory demyelinating polyradiculoneuropathy (CIDP) a rescue treatment for patients relapsing during 1 trial. Methods Open‐label included adult with confirmed CIDP relapse (≥ 1‐point increase adjusted Inflammatory Neuropathy Cause Treatment [INCAT] disability scores from pre‐treatment baseline) 1, which...