A5010037131- Advanced biosensing and bioanalysis techniques
- Food composition and properties
- DNA and Nucleic Acid Chemistry
- Polysaccharides Composition and Applications
- Alzheimer's disease research and treatments
- RNA Interference and Gene Delivery
- Gut microbiota and health
- Molecular Sensors and Ion Detection
- Nanoplatforms for cancer theranostics
- Microbial Metabolites in Food Biotechnology
- Magnetism in coordination complexes
- Metal complexes synthesis and properties
- Probiotics and Fermented Foods
- Advanced Nanomaterials in Catalysis
- Organic and Molecular Conductors Research
- Metal-Organic Frameworks: Synthesis and Applications
- Polysaccharides and Plant Cell Walls
- Nanocluster Synthesis and Applications
- Nanoparticle-Based Drug Delivery
- Lanthanide and Transition Metal Complexes
- Diet and metabolism studies
- Electrochemical Analysis and Applications
- Luminescence and Fluorescent Materials
- X-ray Diffraction in Crystallography
- Crystallization and Solubility Studies
Purdue University West Lafayette
2016-2025
Tongji University
2015-2024
Changchun 208 Hospital
2024
Chinese People's Liberation Army
2024
Shanghai Jiao Tong University
2014-2023
Shanghai East Hospital
2018-2021
Indiana University School of Medicine
2021
Google (United States)
2018
General Hospital of Shenyang Military Region
2012
Nanjing University
1994-2010
Cancer immunotherapy has achieved promising clinical responses in recent years owing to the potential of controlling metastatic disease. However, there is a limited research prove superior therapeutic efficacy on breast cancer compared with melanoma and non-small-cell lung because its expression PD-L1, low infiltration cytotoxic T lymphocytes (CTLs), high level myeloid-derived suppressor cells (MDSCs). Herein, multifunctional nanoplatform (FA-CuS/DTX@PEI-PpIX-CpG nanocomposites, denoted as...
Abstract Given that traditional anticancer therapies fail to significantly improve the prognoses of triple negative breast cancer (TNBC), new modalities with high efficiency are urgently needed. Herein, by mixing metal‐phenolic network formed tannic acid (TA), bleomycin (BLM), and Fe 3+ glutathione peroxidase 4 (GPX4) inhibitor (ML210) loaded hollow mesoporous Prussian blue (HMPB) nanocubes, HMPB/ML210@TA‐BLM‐Fe (HMTBF) nanocomplex is prepared favor ferroptosis/apoptosis synergism in TNBC....
The modern diet delivers nearly equal amounts of carbohydrates and protein into the colon representing an important increase compared to past higher fiber diets.
A logic gate combinatorial library, including basic gates, a single three-input NOR gate, and gates to realize intelligent functions (keypad-lock, parity checker) is constructed.
[Ru(phen)2(dppz)]2+can serve as a prominent molecular "light switch" for G-quadruplexes and i-motif, but it preferentially binds to over i-motif.
The remarkable ability of a new dinuclear RuII complex Ru2(obip)L4 [obip = 2-(2-pyridyl)imidazo[4,5-f][1,10]-phenanthroline; L 2,2′-bipyridine] to promote the formation and stabilization human telomeric repeat AG3(T2AG3)3 quadruplex was reported. experimental results indicated that could induce an antiparallel G-quadruplex structure in absence metal cations. It positive Tm shifts +9.4 +5.8 °C Na+ K+ buffers, respectively, which increase melting temperature stabilizing effect. Binding...
A new ruthenium complex, [Ru(bpy)2dppz-idzo](2+) (bpy = 2,2'-bipyridine, dppz-idzo dipyrido-[3,2-a:2',3'-c] phenazine-imidazolone), was synthesized and characterized. The luminescent titrations showed that the Ru-complex exhibited an outstanding "light switch" effect with emission enhancement factor of about 300 in presence G-quadruplex DNA a K(+) solution. This remarkable behavior can even be observed by naked eye under irradiation UV light. To get insight into mechanism, quantum-chemical...
Herein, we report a new strategy for developing an on-off-on molecular "light switch" by utilizing the pH value to control "conformational of G-quadruplex DNA. A novel ruthenium(II) complex with emission enhancement factor 150 was synthesized and introduced detect switch naked eye. The can be repeatedly cycled off on through addition H(+) OH(-), respectively. conformational transitions DNA in K(+) solution at different values acidic region were evidenced circular dichroism fluorescence...
A novel, selective and sensitive switch-on fluorescent sensor for Hg2+ switch-off probe biothiols was developed by using [Ru(bpy)2(pip)]2+ as the signal reporter graphene oxide (GO) quencher. Due to affinity of GO towards single-stranded DNA (ss-DNA) [Ru(bpy)2(pip)]2+, three components assembled, resulting in fluorescence quenching. Upon addition Hg2+, a double-stranded (ds-DNA) via T–Hg2+–T base pairs formed intercalated into newly ds-DNA. Then, ds-DNA were removed from surface GO,...
Based on the Pt nanozyme modified mesoporous polydopamine in situ, a multi-functional nanoplatform was established, which could overcome tumour hypoxia by catalyzing overexpressed H2O2 cells to enhance photodynamic therapy. In vivo results confirmed that growth inhibited efficiently synergetic
We constructed a series of label-free and multi-output logic circuits using G-quadruplex DNA-templated Ag NCs.