A5082166888- Organ Donation and Transplantation
- Organ Transplantation Techniques and Outcomes
- Renal Transplantation Outcomes and Treatments
- Renal and Vascular Pathologies
- Renal cell carcinoma treatment
- Ureteral procedures and complications
- Pediatric Urology and Nephrology Studies
- Cell Adhesion Molecules Research
- Kidney Stones and Urolithiasis Treatments
- Bladder and Urothelial Cancer Treatments
- Renal and related cancers
- Vascular anomalies and interventions
- Transplantation: Methods and Outcomes
- Central Venous Catheters and Hemodialysis
- Liver Disease and Transplantation
- Urinary and Genital Oncology Studies
- Vascular Procedures and Complications
- Proteoglycans and glycosaminoglycans research
- Urological Disorders and Treatments
- Organ and Tissue Transplantation Research
- Immune Response and Inflammation
- Viral-associated cancers and disorders
- Angiogenesis and VEGF in Cancer
- Polyomavirus and related diseases
- Pancreatic and Hepatic Oncology Research
Freeman Hospital
2013-2025
Jackson Memorial Hospital
2024
Newcastle upon Tyne Hospitals NHS Foundation Trust
2010-2024
Newcastle University
1996-2004
Newcastle upon Tyne Hospital
1997-2004
Leo Pharma (Denmark)
1997
Metabolism and Renal Physiology
1997
Royal Victoria Infirmary
1995
A noninvasive test providing reliable objective quantification of bladder pressure during the voiding cycle would make an important contribution to management lower urinary tract symptoms. We developed a new measure in males based on controlled inflation penile cuff voiding. compared technique with simultaneous invasive measurement.We evaluated 7 volunteers and 32 patients. conventional flow study was performed first. The refilled, fitted after commenced inflated steps 10 cm. water every...
SUMMARY IFN-γ increases the potential immunogenicity of vascular endothelial cells by up-regulation intercellular adhesion molecule-1 (ICAM-1) and class I MHC antigen expression induction II antigens certain chemokines. In this study mechanism which glycosaminoglycan (GAG) heparin antagonizes activation a model endothelium was investigated. Radioligand binding assays demonstrated that total 125I-IFN-γ to EAhy.926 hybridoma cell line reduced in presence or heparan sulphate (HS); structurally...
OBJECTIVE To prospectively compare the accuracy of multislice spiral computed tomographic angiography (CTA) and magnetic resonance (MRA) in evaluating renal vascular anatomy potential living donors. SUBJECTS AND METHODS Thirty‐one donors underwent CTA gadolinium‐enhanced MRA. In addition to axial images, multiplanar reconstruction maximum intensity projections were used display anatomy. Twenty‐four had a left laparoscopic donor nephrectomy (LDN), whereas seven right open (ODN); LDN was only...
Abstract Introduction In kidney transplant patients, ureteric stents have been used to treat, and attempt minimize the risk of, major urological complications (MUCs). 2013 we published a Cochrane review (7 trials) demonstrating efficacy of reduce MUC. This study updates that landmark publication including more recent trials. Methods The Kidney Transplant Specialised Register was searched identify (quasi-) randomised controlled trials include in meta-analysis. Confidence evidence assessed...
Objective To describe a multicentre experience of robot‐assisted partial nephrectomy ( RAPN ) in northern England, with focus on early surgical outcomes and oncological results. Patients Methods All consecutive patients undergoing at four tertiary referral centres England the period 2012–2015 were included for analysis. was performed via transperitoneal approach using standardized technique. Prospective data collection to capture preoperative characteristics (including R.E.N.A.L. nephrometry...
To evaluate the long-term oncological outcomes of patients with upper tract urothelial carcinoma (UTUC) undergoing radical nephroureterectomy (RNU) and impact diagnostic ureteroscopy (URS) on survival outcomes.A retrospective analysis all consecutive RNU for suspected UTUC at a UK tertiary referral centre from prospectively maintained database was conducted. The primary outcome measures were 5- 10-year cancer-specific (CSS). secondary were: overall (OS), recurrence-free (RFS), prior URS OS,...
Donor shortages have led to some groups using alternative sources such as non-heartbeating donors (NHBDs). Kidneys from NHBDs suffer warm ischemia at cardiac arrest which is reflected by acute tubular necrosis of the allograft, resulting in a period delayed graft function. are categorized circumstances surrounding agonal events death reflect differences likelihood ischemic injury kidney. In this study we determined impact on renal function kidneys procured different categories NHBDs.From...
A comparison of laparoscopic and open donor nephrectomy is presented by authors from the UK. They found that approach could safely be offered to patients treated in experienced units after adequate training fo surgeon, with no increase complications or decrease efficacy. OBJECTIVE To compare our early experience (LDN) a contemporary cohort conventional (ODN). PATIENTS AND METHODS Transperitoneal left‐sided LDN was carefully selected potential live kidney donors on basis vascular anatomy. The...
Heparin is a polyanionic glycosaminoglycan (GAG) that can bind with high affinity to range of cytokines including interferon‐γ (IFN‐γ) and members the chemokine superfamily. This GAG also possesses immunomodulatory activity in vivo antagonize capacity IFN‐γ induce class II MHC antigen expression, up‐regulate intercellular adhesion molecule‐1, by cultured endothelial cells. Previous studies have shown binding cell‐surface heparan sulphate essential for optimal free heparin competitively...
Study Type – Therapy (prospective cohort) Level of Evidence 2a What's known on the subject? and What does study add? In West, transitional cell carcinoma (TCC) in renal transplant patients is uncommon, but aggressive. Conversely, it appears to be frequent Far East, necessitating aggressive surgical approaches such as prophylactic nephroureterectomy. There are few European case series date. TCC present population was predominantly low‐grade superficial, with no progression those tumours....
We evaluate whether the preoperative R.E.N.A.L Nephrometry Score (RNS) can predict postoperative outcomes in patients undergoing either an open or laparoscopic partial nephrectomy.We retrospectively calculated RNS of 128 who underwent nephrectomy (OPN) (n = 38) (LPN) 90) between 2003 and 2011. Patients were categorized into low, moderate high complexity groups based on RNSs. Intra-operative warm ischemic time (WIT), peri-operative surgical using Clavien-Dindo classification, histology,...
Heparan sulphate is a common glycosaminoglycan component of proteoglycans present on the luminal surface vascular endothelium. It has been proposed that an important function these molecules sequestration range proinflammatory and proadhesive cytokines. Such cytokines play vital role during lymphocyte recruitment from blood at sites inflammation. In this study it shown effects interferon-gamma (IFN-gamma), but not tumour necrosis factor-alpha (TNF-alpha), are inhibited by treatment with...
Background. We present our centres successful endourological methodology of ex vivo ureteroscopy (EVFUS) in the management these kidneys prior to renal transplantation. Patient and Methods. A retrospective analysis was performed all living donors (n = 157) identified have asymptomatic incidental calculi from January 2004 until December 2008. The incidence 3.2% 5). Donors were subdivided into 2 groups depending on whether theydonated kidney with calculus (Group 1) versus opposite...
Background There is uncertainty around the appropriate management of small renal tumours. Treatments include partial nephrectomy, ablation and active surveillance. Objectives To explore feasibility a randomised trial versus Design Two-stage study: stage 1 – clinician survey co-design work; 2 study with qualitative economic components. Methods Stage radiologists urologists, development patient information materials. patients identified across eight UK centres tumours (< 4 cm) were (1 :...