A5091567735- Genomics and Chromatin Dynamics
- Gene expression and cancer classification
- Luminescence and Fluorescent Materials
- Nanoplatforms for cancer theranostics
- Bioinformatics and Genomic Networks
- Molecular Sensors and Ion Detection
- Wastewater Treatment and Nitrogen Removal
- Single-cell and spatial transcriptomics
- Epigenetics and DNA Methylation
- RNA modifications and cancer
- Advanced biosensing and bioanalysis techniques
- X-ray Diffraction in Crystallography
- Crystallization and Solubility Studies
- Gene Regulatory Network Analysis
- Simulation and Modeling Applications
- Parallel Computing and Optimization Techniques
- Microbial Fuel Cells and Bioremediation
- Water Quality and Pollution Assessment
- Advanced Computational Techniques and Applications
- Genetic Associations and Epidemiology
- Synthesis and biological activity
- Electrochemical sensors and biosensors
- Technology and Security Systems
- Cancer Genomics and Diagnostics
- Graphene and Nanomaterials Applications
North Sichuan Medical University
2003-2025
Affiliated Hospital of North Sichuan Medical College
2019-2025
National University of Singapore
2014-2025
Temasek Life Sciences Laboratory
2025
University of Science and Technology of China
2023-2024
Chinese Academy of Sciences
2023-2024
Changchun University of Technology
2024
Huazhong University of Science and Technology
2024
South China Municipal Engineering Design and Research Institute (China)
2023-2024
University of Wisconsin–Madison
2018-2023
Abstract Cell type-specific gene expression patterns are outputs of transcriptional regulatory networks (GRNs) that connect transcription factors and signaling proteins to target genes. Single-cell technologies such as single cell RNA-sequencing (scRNA-seq) Assay for Transposase-Accessible Chromatin using sequencing (scATAC-seq), can examine cell-type specific regulation at unprecedented detail. However, current approaches infer GRNs limited in their ability integrate scRNA-seq scATAC-seq...
The three-dimensional (3D) organization of the genome plays an important role in gene regulation bringing distal sequence elements 3D proximity to genes hundreds kilobases away. Hi-C is a powerful genome-wide technique study organization. Owing experimental costs, high resolution datasets are limited few cell lines. Computational prediction counts can offer scalable and inexpensive approach examine across multiple cellular contexts. Here we present HiC-Reg, predict contact from...
GM Jatropha X8#34 was placed for transgene flow assessment in the open field trial on Semakau Island, Singapore, between 2015 and 2017 to evaluate potential gene its non-GM counterparts related species. The featured event X8#34, which is characterized by high oleic acid content, marker-free, a homozygous transgene. study focused cross-pollination from plants, analyzing factors such as distance, wind insects mediated transfer, using event-specific multiplex PCR analysis of F1 seeds. Pollen...
Abstract Background There is a growing interest in Jatropha curcas L. (jatropha) as biodiesel feedstock plant. Variations its morphology and seed productivity have been well documented. However, there the lack of systematic comparative evaluation distinct collections under same climate agronomic practices. With several reports on low genetic diversity jatropha collections, uncertainty contribution to morphology. Result In this study, five populations plants collected from China (CN),...
By functionalizing triarylboron with cyclen, we developed a water-soluble two-photon ratiometric probe nucleolar targeting by preferential RNA binding.
Previous genome-wide association studies (GWAS) have identified several common genetic variants that may significantly modulate cancer susceptibility. However, the precise molecular mechanisms behind these associations remain largely unknown; it is often not clear whether discovered are themselves functional or merely genetically linked to other variants. Here, we provide an integrated method for identifying regulatory associated with and their target genes by combining analyses of...
Somatic embryogenesis receptor kinase (SERK) proteins play pivotal roles in regulation of plant development and immunity. The rice genome contains two SERK genes, OsSerk1 OsSerk2. We previously demonstrated that OsSerk2 is required for Xa21-mediated resistance to Xanthomonas oryzae pv. (Xoo) normal development. Here we report the molecular characterization OsSerk1. Overexpression results a semi-dwarf phenotype whereas silencing reduced angle lamina joint. not Xoo or Magnaporthe oryzae....
One key reason for the failure of Jatropha plantation is use non-improved planting materials. We present in this paper a variety (JO S2) through selective breeding with much better seed productivity than wild accessions as proven by field trials Singapore and India. In single farm trial two years, comparison was conducted from China, India, Indonesia Africa. It found that all traits studied like yield, kernel content, oil fatty acid composition, phosphorus content PE differed significantly...
Genome-wide association studies (GWAS) have hitherto identified several germline variants associated with cancer susceptibility, but the molecular functions of these risk modulators remain largely uncharacterized. Recent begun to uncover regulatory potential non-coding GWAS SNPs by using epigenetic information in corresponding cell types and matched normal tissues. However, this approach does not explore effect on other important that constitute microenvironment tumor or its precursor. This...