A5050103343- Diet and metabolism studies
- MicroRNA in disease regulation
- Diet, Metabolism, and Disease
- Dietary Effects on Health
- Extracellular vesicles in disease
- Bariatric Surgery and Outcomes
- Digestive system and related health
- Pancreatic function and diabetes
- Birth, Development, and Health
- Galectins and Cancer Biology
- Endoplasmic Reticulum Stress and Disease
- Metabolism, Diabetes, and Cancer
Peking University
2022-2025
MaineHealth
2025
Obesity is a global health challenge associated with significant metabolic and cardiovascular risks. Bariatric surgery GLP-1 receptor agonists (GLP-1RAs) are effective interventions for weight loss improvement, yet their comparative effects on systemic metabolism-particularly energy metabolism, bone health, heart function-remain unclear. In this study, obese male mice underwent vertical sleeve gastrectomy (VSG), 6 weeks of GLP-1RA (semaglutide) treatment, or sham procedure saline injection...
Background: Whether intestinal epithelial cells can regulate distant adipose tissue remains a mystery. Methods: Cold-stimulated cell-derived exosomes (Cold IEC-Exo) play pivotal role in enhancing thermogenesis and metabolic homeostasis, as demonstrated this study. Results: IEC-Exo accumulate tissue. Compared with derived from room temperature mice (RT IEC-Exo), Cold significantly enhanced the of adipose. In vitro, directly stimulated primary adipocytes by elevating oxygen consumption rate,...
Maternal nutrition plays a critical role in energy metabolism of offspring. We aim to elucidate the effect long-term intermittent fasting (IF) before pregnancy on health outcomes Here we show IF disrupts intestinal homeostasis offspring with subsequent disorder glucose and lipid metabolism. This occurs through reduction beneficial microbiota such as Lactobacillus_intestinalis. Our observations further support concept that is vulnerable maternal nutrition, its for integrity barrier metabolic...
Abstract The metabolic benefits of intermittent fasting (IF) have been well recognized. However, limited studies examined the relationship between long‐term maternal IF before pregnancy and offspring health. In this study, a C57BL/6J mouse model was established: 4‐week‐old female mice were subjected to alternate‐day for 12 weeks resumed normal diet after mating. Female in control group fed ad libitum. Offspring weaned at 6 age chow or 60% high‐fat diet. effects pre‐pregnancy on metabolism...
The "gut-liver axis" is critical for the control of hepatic lipid homeostasis, where intestine affects liver through multiple pathways, such as nutrient uptake, gastrointestinal hormone release, and gut microbiota homeostasis. Whether intestine-originated exosomes mediate gut's influence on steatosis remains unknown. Here, we aimed to determine whether intestinal epithelium-derived (intExos) contribute regulation metabolism. We found that mouse intExos could be taken up by cells. Mice fed...
Abstract Whether intestinal Leucine-rich repeat containing G-protein-coupled receptor 4 (LGR4) impacts nutrition absorption and energy homeostasis remains unknown. Here, we report that deficiency of Lgr4 ( iKO ) in epithelium decreased the proportion enterocytes selective for long-chain fatty acid absorption, leading to reduction lipid subsequent improvement glucose metabolism. Single-cell RNA sequencing demonstrates heterogeneity absorptive enterocytes, with a decrease acid-absorption an...