A5054150725- 3D Printing in Biomedical Research
- Pancreatic function and diabetes
- Tissue Engineering and Regenerative Medicine
- Adipose Tissue and Metabolism
- Diet and metabolism studies
- Diet, Metabolism, and Disease
- Dietary Effects on Health
- Regulation of Appetite and Obesity
- Biochemical Analysis and Sensing Techniques
- Metabolism, Diabetes, and Cancer
- Birth, Development, and Health
- Lipid metabolism and biosynthesis
- Additive Manufacturing and 3D Printing Technologies
- Electrospun Nanofibers in Biomedical Applications
- Hematological disorders and diagnostics
- Heme Oxygenase-1 and Carbon Monoxide
- Cholesterol and Lipid Metabolism
- Hippo pathway signaling and YAP/TAZ
- Liver Disease Diagnosis and Treatment
- Immune Response and Inflammation
- Gastrointestinal Tumor Research and Treatment
- Pluripotent Stem Cells Research
- Digestive system and related health
- Bone health and treatments
- Fibroblast Growth Factor Research
Peking University
2018-2024
Beijing Tsinghua Chang Gung Hospital
2022-2024
Tsinghua University
2022-2024
Central People's Hospital of Zhanjiang
2008
The cellular and molecular mechanisms by which indole-3-acetic acid (IAA), a tryptophan-derived metabolite from gut microbiota, attenuates inflammation oxidative stress has not been fully elucidated. present study was to unearth the protective effect underlying mechanism of IAA against lipopolysaccharide (LPS)-induced inflammatory response free radical generation in RAW264.7 macrophages. significantly ameliorated LPS-induced expression interleukin-1β (IL-1β), interleukin-6 (IL-6), monocyte...
Intracellular lipid accumulation is commonly seen in fibrotic livers, but its exact role liver fibrosis remains elusive. Here, we established a multimodal nonlinear optical microscopy to quantitatively map distribution of biomolecules livers. Our data revealed that unsaturated triglycerides were predominantly accumulated central vein area during not portal area. Moreover, the homeostasis was remarkably dysregulated late-stage compared early-stage fibrosis, including increased with decreased...
The mammalian target of rapamycin (mTOR) is an important protein kinase that senses changes in extracellular and intracellular energy levels plays a key role regulating metabolism. Brown adipose tissue, which can be converted to white contains large number mitochondria regulates expenditure through thermogenesis. Because obesity process fat accumulation due chronic excessive intake, we attempted determine whether the mTOR signaling pathway affect mitochondrial quality control brown...
Roux-en-Y Gastric Bypass Surgery (RYGB) prevents the occurrence of pancreatic cell acinar carcinoma (ACC) in male and female Ngn3-Tsc1-/- mice. Ngn3 directed Cre deletion Tsc1 gene induced development ACC. The transgenic mice with sham surgery demonstrated a cancer incidence 96.7 ± 3.35% survival rate 67.0 1.4% at age 300 days. Metastasis to liver kidney was observed 69.7 9.7% 44.3 8.01% these animals, respectively. All animals RYGB performed 16 weeks survived free ACC up significantly...
Maternal nutrition plays a critical role in energy metabolism of offspring. We aim to elucidate the effect long-term intermittent fasting (IF) before pregnancy on health outcomes Here we show IF disrupts intestinal homeostasis offspring with subsequent disorder glucose and lipid metabolism. This occurs through reduction beneficial microbiota such as Lactobacillus_intestinalis. Our observations further support concept that is vulnerable maternal nutrition, its for integrity barrier metabolic...
Abstract The metabolic benefits of intermittent fasting (IF) have been well recognized. However, limited studies examined the relationship between long‐term maternal IF before pregnancy and offspring health. In this study, a C57BL/6J mouse model was established: 4‐week‐old female mice were subjected to alternate‐day for 12 weeks resumed normal diet after mating. Female in control group fed ad libitum. Offspring weaned at 6 age chow or 60% high‐fat diet. effects pre‐pregnancy on metabolism...
Gastric mechanistic target of rapamycin (mTOR) signaling is inversely associated with the expression and secretion ghrelin, a 28‐aa peptide hormone produced by gastric X/A‐like cells. Ghrelin contributes to obesity hepatic steatosis. We sought control global lipid metabolism via manipulation mTOR in established ghrl‐cre transgene which Cre enzyme expressed cells under ghrelin‐promoter. mTORflox/flox tuberous sclerosis 1 ( TSC1)flox/flox mice were separately bred generate mTOR‐ghrl‐cre or...
The liver, as the body's primary organ for maintaining internal balance, is composed of numerous hexagonal liver lobules, each sharing a uniform architectural framework. These lobules serve basic structural and functional units comprised central veins, hepatic plates, sinusoids, minute bile ducts. Meanwhile, within distinct regions hepatocytes carry out diverse functions. in vitro construction lobule models, faithfully replicating their structure function, holds paramount significance...
Hepatocellular carcinoma (HCC) is a highly malignant tumor with poor prognosis. More than 30% of patients diagnosed HCC have abnormally high expression fibroblast growth factor receptor 4 (FGFR4). Currently, clinical trials for variety FGFR4-specific inhibitors started. However, the effect these not ideal, and it necessary to find drug combination synergistically exert anti-tumor effects. We found strong correlations between FGFR4 clinicopathological characteristics in present study. After...
Single-nucleotide polymorphisms in G protein-coupled receptor 180 (GPR180) are associated with hypertriglyceridemia. The aim of this study was to determine whether hepatic GPR180 impacts lipid metabolism. Hepatic knocked down using two approaches: Gpr180-specific short hairpin (sh)RNA carried by adeno-associated virus 9 (AAV9) and alb-Gpr180−/− transgene established crossbreeding albumin-Cre mice Gpr180flox/flox animals, which Gpr180 specifically hepatocytes. Adiposity, contents, proteins...
Aim: Our aim was to explore how maternal intermittent fasting (IF) influences offspring metabolism. Materials & methods: A model of female C57BL/6J mice alternate-day feeding before mating established and alteration hepatic DNA methylation in analyzed by whole genome bisulfite sequencing. Results: IF dams weighed less (p = 0.03) had lower random blood glucose levels 0.04). Lower birth weight 0.0031) impaired metabolism were also observed the mice. The genome-wide maps showed a correlation...
Abstract Whether intestinal Leucine-rich repeat containing G-protein-coupled receptor 4 (LGR4) impacts nutrition absorption and energy homeostasis remains unknown. Here, we report that deficiency of Lgr4 ( iKO ) in epithelium decreased the proportion enterocytes selective for long-chain fatty acid absorption, leading to reduction lipid subsequent improvement glucose metabolism. Single-cell RNA sequencing demonstrates heterogeneity absorptive enterocytes, with a decrease acid-absorption an...
Objective To explore the diagnosis and treatment of gastrointestinal stromal tumors(GIST).Methods 26 patients with tumors in Ji'an Central People's Hospital from 1998 to 2006 Were retrospectively analyzed.Results All received operation.Of them,low malignant GIST wag 17 eases,high 9.All were follwod-up 6 84 months.4 ofthem had local recurrence metastasis 5 eases died.Condusion The Was dimcult because lack clinical features.Final should be based on IHC pathology.The main choice...