A5107657112- Glioma Diagnosis and Treatment
- Meningioma and schwannoma management
- Advanced Neuroimaging Techniques and Applications
- Radiomics and Machine Learning in Medical Imaging
- Brain Metastases and Treatment
- Advanced MRI Techniques and Applications
- Spine and Intervertebral Disc Pathology
- Spinal Fractures and Fixation Techniques
- Neurobiology of Language and Bilingualism
- Pituitary Gland Disorders and Treatments
- Epilepsy research and treatment
- Medical Imaging Techniques and Applications
- MRI in cancer diagnosis
- Systemic Lupus Erythematosus Research
- Advanced Chemical Sensor Technologies
- Multiple Sclerosis Research Studies
- Head and Neck Surgical Oncology
- Management of metastatic bone disease
- Spinal Hematomas and Complications
- Vascular Malformations Diagnosis and Treatment
- Medical Imaging and Analysis
- Soft Robotics and Applications
- Adrenal and Paraganglionic Tumors
- Bone and Joint Diseases
- Intraoperative Neuromonitoring and Anesthetic Effects
Humanitas University
2014-2025
IRCCS Humanitas Research Hospital
2012-2025
Vita-Salute San Raffaele University
2011-2025
Cebu Institute of Technology University
2024
University of Milan
2013-2022
Neurological Surgery
2022
University of California, San Francisco
2022
Istituto Ortopedico Galeazzi
2020-2021
Istituti di Ricovero e Cura a Carattere Scientifico
2007-2021
Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico
2014-2020
Craniopharyngioma accounts for 2%-5% of all primary intracranial neoplasms. The optimal management craniopharyngioma remains controversial. authors evaluated the early results surgery and longterm risk tumor recurrence in a large series patients undergoing resection craniopharyngiomas.Between 1990 2008, 112 consecutive (57 male 55 female with mean [± SEM] age 33.3 ± 1.8 years) underwent craniopharyngiomas at authors' hospital. Recurrence or growth residual tissue during follow-up was...
Resection of lesions involving motor or language areas pathways requires the intraoperative identification functional cortical and subcortical sites for effectively safe guidance. Diffusion tensor (DT) imaging fiber tractography are MR techniques based on concept anisotropic water diffusion in myelinated fibers, which enable 3D reconstruction visualization white matter tracts provide information about relationship these to tumor mass. The authors routinely used DT reconstruct various...
Diffusion tensor imaging (DTI) tractography enables the in vivo visualization of course white matter tracts inside or around a tumor, and it provides surgeon with important information resection planning. This study is aimed at assessing ability preoperative DTI predicting extent achievable surgical removal gliomas. Patients low-grade gliomas (LGGs; 46) high-grade (HGGs; 27) were studied using 3T scanner according to protocol including morphological (T2, fluid-attenuated inversion-recovery,...
BackgroundResection of motor pathway gliomas requires the intraoperative recognition essential cortical-subcortical structures. The degree involvement structures is variable, and increases as result treatments patients are submitted to. Intraoperative neurophysiology offers various stimulation modalities, which efficiency based on ability to recognize sites with highest possible resolution in most clinical conditions. Two paradigms evolved for guidance tumors removal: 60 Hz-technique [low...
Abstract The cortical and subcortical neural correlates underlying item order information in verbal short‐term memory (STM) were investigated by means of digit span 29 patients with direct electrical stimulation during awake surgery for removal a neoplastic lesion. Stimulation left Broca's area interfered span, producing significantly more than errors, as compared to the supramarginal/angular gyrus, which also but, conversely, produced errors. Similarly, third segment superior longitudinal...
Abstract Background Supratotal resection is advocated in lower-grade gliomas (LGGs) based on theoretical advantages but with limited verification of functional risk and data oncological outcomes. We assessed the association supratotal molecularly defined LGGs Methods Included were 460 presumptive LGGs; 404 resected; 347 LGGs, 319 isocitrate dehydrogenase (IDH)–mutated, 28 wildtype. All patients had clinical, imaging, molecular data. Resection aimed at without any patient or tumor a priori...
Identifying tumor cells infiltrating normal-appearing brain tissue is critical to achieve a total glioma resection. Raman spectroscopy (RS) an optical technique with potential for real-time detection. Most RS reports are based on formalin-fixed or frozen samples, only few studies deployed fresh untreated tissue. We aimed probe biopsies exploring novel bands useful in distinguishing and normal Sixty-three were analyzed within minutes after A of 3450 spectra collected, 1377 labelled as Healthy...
Abstract Background Although invasiveness is one of the major determinants poor glioblastoma (GBM) outcome, mechanisms GBM invasion are only partially understood. Among intrinsic and environmental processes promoting cell-to-cell interaction processes, eventually driving invasion, we focused on pro-invasive role played by Extracellular Vesicles (EVs), a heterogeneous group cell-released membranous structures containing various bioactive cargoes, which can be transferred from donor to...
The transport of fluids and substances within the brain parenchyma (i.e. interstitial transport) is fundamental to maintaining health delivering treatments for neurological disorders. However, accurately predicting these processes has remained a formidable challenge due intricate dynamic nature brain's microenvironment. Here, we report novel, fully validated bottom-up mechanistic framework that bridges advanced mathematical modelling, ultra-high-resolution imaging, biomechanical testing...
Objective To assess the role of superior longitudinal fascicle, inferior fronto‐occipital and posterior parietal lobe in visuospatial attention humans during awake brain surgery. Experimental design Seven patients with hemispheric gliomas (six right hemisphere) entered study. During surgery asleep/awake anesthesia, guided by Diffusion Tensor Imaging Fiber Tractography, neglect was assessed direct electrical stimulation computerized line bisection. Principal observations A rightward...
OBJECTIVE The goal of surgery for gliomas is maximal tumor removal while preserving the patient’s full functional integrity. At present during frontal removal, this mostly achieved, although risk impairing executive functions (EFs), and thus quality life, remains significant. authors investigated accuracy an intraoperative version Stroop task (iST), adapted mapping, to detect EF-related brain sites by evaluating impact iST mapping on integrity following a resection. METHODS Forty-five...
Surgery for low-grade gliomas (LGGs) aims to achieve maximal tumor removal and maintenance of patients' functional integrity. Because extent resection is one the factors affecting natural history LGGs, surgery could be extended further than total toward a supratotal resection, beyond borders detectable on FLAIR imaging. Supratotal highly debated, mainly due lack evidence its feasibility safety. The authors explored intraoperative short- long-term impact integrity in large cohort patients....
Abstract Background Differentiating radionecrosis from neoplastic progression after stereotactic radiosurgery (SRS) for brain metastases is a diagnostic challenge. Previous studies have often been limited by datasets lacking histologically confirmed diagnoses. This study aimed to develop automated models distinguishing disease on MRI, utilizing cases with definitive histopathological confirmation. Methods multi-center retrospective included patients who underwent surgical resection suspected...
Abstract Brain tissue microstructure influences the efficient delivery of therapeutics within brain. Diffusion Tensor Imaging (DTI) enables depiction properties in vivo, and thus is potentially relevant for planning convection-enhanced (CED) We report on quantitative assessment distribution a Gadolinium solution infused by CED brain live ovine model. Infusate distributions were measured at multiple timepoints compared to microstructural as depicted DTI, demonstrating impact features catheter...
ABSTRACT PURPOSE Neurite orientation dispersion and density imaging (NODDI) has recently been developed to overcome diffusion technique limitations in modeling biological systems. This manuscript reports a preliminary investigation into the use of single color‐coded map represent NODDI‐derived information. MATERIALS AND METHODS An optimized diffusion‐weighted protocol was acquired several clinical neurological contexts including demyelinating disease, neoplastic process, stroke,...
OBJECTIVE Apraxia is a cognitive-motor deficit affecting the execution of skilled movements, termed praxis gestures, in absence primary sensory or motor disorders. In patients affected by stroke, apraxia associated with lesions lateral parietofrontal stream, connecting posterior parietal areas ventrolateral premotor area and subserving sensory-motor integration for hand movements. neurosurgical literature to date, there are few reports regarding incidence after glioma surgery. A...
OBJECT Intraoperative language mapping is traditionally performed with low-frequency bipolar stimulation (LFBS). High-frequency train-of-five delivered by a monopolar probe (HFMS) an alternative technique for motor mapping, lower reported seizure incidence. The application of HFMS in still limited. Authors this study assessed the efficacy and safety during awake surgery, exploring its clinical impact compared that LFBS. METHODS Fifty-nine patients underwent surgery neuropsychological...
Brain mapping techniques allow one to effectively approach tumors involving the primary motor cortex (M1). Tumor resectability and maintenance of patient integrity depend on ability successfully identify tracts during resection by choosing most appropriate neurophysiological paradigm for mapping. Mapping with a high-frequency (HF) stimulation technique has emerged as efficient tool because its versatility in different clinical settings. At present, few data are available use HF removal...