A5059634078- Magnetic properties of thin films
- Inflammatory mediators and NSAID effects
- Advanced Condensed Matter Physics
- Estrogen and related hormone effects
- Tendon Structure and Treatment
- Multiferroics and related materials
- Cancer, Hypoxia, and Metabolism
- Shoulder Injury and Treatment
- Hormonal and reproductive studies
- Sports injuries and prevention
- Nanoplatforms for cancer theranostics
- Physics of Superconductivity and Magnetism
- Theoretical and Computational Physics
- Cancer, Stress, Anesthesia, and Immune Response
- Magneto-Optical Properties and Applications
- NMR spectroscopy and applications
- Pulmonary Hypertension Research and Treatments
- Hormonal Regulation and Hypertension
- Photodynamic Therapy Research Studies
- Radiopharmaceutical Chemistry and Applications
- Magnetic and transport properties of perovskites and related materials
- Geophysical and Geoelectrical Methods
- Angiogenesis and VEGF in Cancer
- Magnetic Properties of Alloys
- Cell Adhesion Molecules Research
University of Strathclyde
2023-2024
The Queen's Medical Research Institute
2018-2023
University of Edinburgh
2021-2023
Technical University of Munich
2014-2021
Johns Hopkins University
2007-2017
Morgan State University
2012-2017
Johns Hopkins Medicine
2004-2015
Imaging Center
2015
University of Baltimore
2012-2015
Agios Pavlos General Hospital
2013
Wave control in the solid state has opened new avenues modern information technology. Surface-acoustic-wave-based devices are found as mass market products 100 millions of cellular phones. Spin waves (magnons) would offer a boost today's data handling and security implementations, i.e., image processing speech recognition. However, nanomagnonic realized so far suffer from relatively short damping length metallic ferromagnets amounting to few 10 micrometers typically. Here we demonstrate that...
Rationale: Inhibition of aromatase with anastrozole reduces pulmonary hypertension in experimental models. Objectives: We aimed to determine whether improved the 6-minute-walk distance (6MWD) at 6 months arterial (PAH). Methods: performed a randomized, double-blind, placebo-controlled phase II clinical trial subjects PAH seven centers. Eighty-four postmenopausal women and men were randomized 1:1 ratio receive 1 mg or placebo by mouth daily, stratified sex using permuted blocks variable...
To compare the effectiveness of an exercise programme, pulsed ultrasound and transverse friction in treatment chronic patellar tendinopathy.Randomized controlled trial.Rheumatology Rehabilitation Centre.This study was carried out with 30 patients who had tendinopathy. They were randomized into three groups.Group A (n = 10) treated programme. Pulsed given to group B 10). Group C received friction. All treatments per week for four weeks.Patients' pain evaluated at end four-week course (week...
The homeotic gene HOXA5 has been shown to play an important role in breast tumorigenesis. We have that loss of p53 correlated with a developmentally regulated transcription factor, HOXA5, primary cancer. Searching for potential protein interacting partners we found binds anti-apoptotic protein, Twist. Furthermore, Twist-overexpressing MCF-7 cells displayed deregulated response γ-radiation and decreased regulation downstream target genes. Using p53-promoter-reporter system, demonstrated could...
Objective: To compare the effectiveness of Cyriax physiotherapy, a supervised exercise programme, and polarized polychromatic non-coherent light (Bioptron light) in treatment lateral epicondylitis. Design: Controlled clinical trial. Setting: Rheumatology rehabilitation centre. Subjects: This study was carried out with 75 patients who had They were allocated to three groups by sequential allocation. Interventions: Group A ( n=25) treated physiotherapy. programme given group B n=25). C...
Although the mechanisms through which hypoxia influences several phenotypic characteristics such as angiogenesis, selection for resistance to apoptosis, radiation and chemotherapy, increased invasion metastasis are well characterized, relationship between tumor components of extracellular matrix (ECM) is relatively unexplored. The collagen I (Col1) fiber solid tumors major structural part ECM. Col1 density can increase initiation, progression, metastasis, with cancer cell occurringalong...
We report broadband spin-wave spectroscopy on kagome artificial spin ice (ASI) made of large arrays interconnected Ni$_{80}$Fe$_{20}$ nanobars. Spectra taken in saturated and disordered states exhibit a series resonances with characteristic magnetic field dependencies. Making use micromagnetic simulations, we identify that reflect the spin-solid-state monopole-antimonopole pairs Dirac strings. The latter allow for generation highly-charged vertices ASIs via microwave assisted switching. Our...
Broadband microwave spectroscopy has been performed on single-crystalline GaV$_4$S$_8$, which exhibits a complex magnetic phase diagram including cycloidal, N\'eel-type skyrmion lattice, as well field-polarized ferromagnetic phases below 13 K. At zero and small fields two collective modes are found at 5 15 GHz, characteristic of the cycloidal state in this easy-axis magnet. In finite fields, entering lattice phase, spectrum transforms into multi-mode pattern with absorption peaks near 4, 8,...
Using conventional coplanar waveguides (CPWs), we excited spin waves with a wavelength λ down to 310 nm in 200 thin yttrium iron garnet film grown by liquid phase epitaxy. Spin-wave transmission was detected between CPWs that separated up 2 mm. For magnetostatic surface waves, found large nonreciprocity of 0.9 and high group velocity vg 5.4 km/s. The extracted decay length ld amounted 0.86 Small λ, vg, are key figures merit when aiming at non-charged based signal logic devices waves.
Chiral magnets are promising materials for the realisation of high-density and low-power spintronic memory devices. For these future applications, a key requirement is synthesis appropriate in form thin films ordering well above room temperature. Driven by Dzyaloshinskii-Moriya interaction, cubic compound FeGe exhibits helimagnetism with relatively high transition temperature 278 K bulk crystals. We demonstrate that this can be enhanced significantly films. Using x-ray scattering...
Abstract Cyclooxygenases (COX) are rate-limiting enzymes involved in the conversion of PLA2-mobilized arachidonic acid into prostaglandins and thromboxanes. COX-2 is a key mediator inflammation during both physiologic pathologic responses to endogenous stimuli infectious agents. Its overexpression has been detected different cancers, including that breast. Using RNA interference, we have reduced expression highly malignant breast cancer cell line MDA-MB-231 below detectable levels response...
Background Home and supervised exercise programmes consisting of stretching eccentric exercises have been recommended for the management lateral elbow tendinopathy (LET). No studies examined their comparative efficacy effectiveness. Objective In this study, whether a home programme is more successful than in treating patients with LET was investigated. Methods Patients unilateral at least 4 weeks were included trial. They sequentially allocated to receive either or five times week 12 weeks....
The networks of blood and lymphatic vessels the extracellular matrix their cellular structural components, that are collectively termed tumor microenvironment, frequently co-opted shaped by cancer cells to survive, invade, form distant metastasis. With an enviable capacity adapt continually changing environments, represents epitome functional chaos, a stark contrast hierarchical organized differentiation processes dictate development life biological organisms. consequences landscapes such as...
Cyclooxygenase-2 (COX-2) is a critically important mediator of inflammation that significantly influences tumor angiogenesis, invasion, and metastasis. We investigated the role COX-2 expressed by triple negative breast cancer cells in altering structure function extracellular matrix (ECM). downregulation effects on ECM were using magnetic resonance imaging (MRI) second harmonic generation (SHG) microscopy tumors derived from MDA-MB-231 cells, clone stably expressing short hairpin (shRNA)...
Estrogens regulate many diverse biological processes in health and disease. They circulate at a wide range of concentrations females generating several active metabolites (hydroxy methoxyestrogens). The are assumed to be present much lower levels thought contribute diseases such as pulmonary arterial hypertension (PAH). Estrogen challenging quantify plasma currently available immunoassays non-specific. Here we have developed validated novel assay simultaneously parent estrogens their by mass...
Chiral magnets with topologically nontrivial spin order such as Skyrmions have generated enormous interest in both fundamental and applied sciences. We report broadband microwave spectroscopy performed on the insulating chiral ferrimagnet Cu2OSeO3. For damping of magnetization dynamics, we find a remarkably small Gilbert parameter about 1×10−4 at 5 K. This value is only factor 4 larger than one reported for best yttrium iron garnet room temperature. detect series sharp resonances attribute...
AbstractThe COX pathway has been a target for pharmaceutical intervention in diseases with high inflammatory component ranging from asthma and Alzheimer's to arthritis cancer. A major transcriptional promoter of the malignant phenotype, HIF-1α, observed be regulated by COX-2 product PGE2. Here we show that HIF-1α protein significantly accumulated human breast cancer MDA-MB-231 cells response pro-inflammatory cytokine IL-1β, but not COX-2-silenced cells. In contrast expression could detected...
We report an experimental study of the emergence non-trivial topological winding and long-range order across paramagnetic to skyrmion lattice transition in metal helimagnet MnSi. Combining measurements susceptibility with small angle neutron scattering, resonance spin echo spectroscopy all-electrical microwave spectroscopy, we find evidence textures state exceeding $10^3$\AA lifetimes above several 10$^{-9}$s. Our findings establish that MnSi is well-described by Landau soft-mode mechanism...
Using ferromagnetic resonance spectroscopy at 34 GHz we explored the magnetic anisotropy of single-crystalline GaV4S8 in field-polarized state. We describe data terms an easy-axis type uniaxial with constant [Formula: see text] erg cm-3 2 K, corresponding to a relative exchange text]%, and about text]erg near 11 i.e. temperatures where skyrmion-lattice phase was recently discovered. The relatively large value K 1 explains confinement skyrmion tubes easy axes. A distinct set resonances...
Background Data: The use of low-level laser therapy (LLLT) and polarized polychromatic non-coherent light as supplements to an exercise program has been recommended for the management lateral elbow tendinopathy (LET). Objective: To investigate whether supplemented with LLLT is more successful than in treating LET. Materials Methods: Patients unilateral LET at least 4 wk were sequentially allocated receive either or light. consisted eccentric static stretching exercises wrist extensors. In...
We report angular-dependent spin-wave spectroscopy on kagome artificial spin ice made of large arrays interconnected Ni80Fe20 nanobars. Spectra taken in saturated and disordered states exhibit a series resonances with characteristic in-plane angular dependencies. Micromagnetic simulations allow us to interpret two-step magnetization reversal the nanomagnets. The dynamic properties are consistent topological defects that provoked via magnetic field applied at specific angles. Simulations we...