A5101513976- MicroRNA in disease regulation
- Mesenchymal stem cell research
- Electrospun Nanofibers in Biomedical Applications
- Circular RNAs in diseases
- Cardiac Ischemia and Reperfusion
- Tissue Engineering and Regenerative Medicine
- Cancer-related molecular mechanisms research
- Autophagy in Disease and Therapy
- Musculoskeletal pain and rehabilitation
- Healthcare and Venom Research
- RNA Interference and Gene Delivery
- Cardiac electrophysiology and arrhythmias
- Cell death mechanisms and regulation
- Neuroscience and Neuropharmacology Research
- Attention Deficit Hyperactivity Disorder
- Wound Healing and Treatments
- Extracellular vesicles in disease
- Spine and Intervertebral Disc Pathology
- Prion Diseases and Protein Misfolding
- Signaling Pathways in Disease
- Water Governance and Infrastructure
- Livestock Management and Performance Improvement
- Peripheral Neuropathies and Disorders
- Asthma and respiratory diseases
- Cardiac Fibrosis and Remodeling
Seoul National University
2024
Chung-Ang University
2024
Pusan National University
2019-2023
Pusan National University Hospital
2023
Seoul National University Bundang Hospital
2018
Yonsei University
2009-2017
Yonsei University Health System
2015
International St. Mary's Hospital
2015
Catholic Kwandong University
2015
Abstract Introduction Mesenchymal stem cells (MSCs) have therapeutic potential for the repair of myocardial injury. The efficacy MSC therapy regeneration mainly depends on survival after transplantation into infarcted heart. In transplanted regions, reactive oxygen species (ROS) can cause cell death, and this process caspase activation autophagosome formation. Methods A Software TargetScan was utilized to search microRNAs (miRNAs) that target caspase-3 mRNA. Six candidate miRNAs including...
Adult stem cells have been studied as a promising therapeutic modality for the functional restoration of damaged heart. In present study, strategy enhancing angiogenic efficacy human mesenchymal (hMSCs) using micro-RNA was examined. We investigated whether micro-RNA-146a (miR-146a) influences secretion vascular endothelial growth factor (VEGF) and angiogenesis MSCs. Our data indicated that miR-146a-transfected hMSCs (hMSCmiR-146a) decreased expression neurofibromin 2, an inhibitor...
Onju Ham, Chang Youn Lee, Byeong-Wook Song, Se-Yeon Ran Kim, Jun-Hee Park, Jiyun Hyang-Hee Seo, Chae Yoon Yong-An Chung, Lee-So Maeng, Min Young Jongmin Jihwan Hwang, Dong Kyun Woo, and Woochul Chang*. Mol. Cells 2014;37:449-56. https://doi.org/10.14348/molcells.2014.0023
Minor salivary gland mesenchymal stem cells (MSGMSCs) can be easily extracted and have a broad range of sources. Applying exosomes to wounds is highly promising method for promoting wound healing. Exosomes derived from different cell types been proven enhance healing, with adipose-derived (ADSC)-derived being the most extensively researched. Considering that MSGMSCs advantages such as easier extraction compared ADSCs, should also very type in exosome therapy. However, whether MSGMSC-derived...
Abstract Genetic ablation of BCL2/adenovirus E1B 19 kDa protein-interacting protein 3 (BNIP3), an essential regulator cardiac cell death, is effective way to prevent death triggered by pathologic conditions. However, currently there exists no known means, such as inhibitors, down-regulate BNIP3 in mature heart. Here, we report that a small molecule inducer microRNA-182 (miR-182) suppressed ischemia/reperfusion (I/R)-induced down-regulating BNIP3. We first selected miR-182 potent...
Mesenchymal stem cells (MSCs) have the potential to repair and regenerate ischemic heart tissue; however, poor viability of transplanted MSCs in region is a major obstacle their therapeutic use. This cell death caused by Fas ligand (FasL) interactions under harsh conditions. To investigate improving survival effects MSCs, we focused our research on Fas–FasL-mediated death. In this study, found that was Fas–FasL between host myocardial implanted MSCs. addition, increased expression...
Emerging evidence suggests that cell therapy with mesenchymal stem cells (MSCs) has beneficial effects on the injured heart. However, decreased survival and/or adhesion of MSCs under ischemic conditions limits application transplantation as a therapeutic modality. We investigated potential method increasing ability to improve their efficacy in Treatment PKC activator, phorbol 12-myristate 13-acetate (PMA), increased and spreading dose-dependent significantly detachment. When were treated...
Low survival rate of transplanted cells compromises the efficacy cell therapy. Hexokinase II (HKII) is known to have anti-apoptotic activity through its interaction with mitochondria. The objective was identify miRNAs targeting HKII and investigate whether miRNA-mediated modulation could improve mesenchymal stem (MSCs) exposed H2O2. expression in MSCs H2O2 evaluated, HKII-targeting miRNA screened based on miRNA-target prediction databases. effect selected examined using anti-miRNA...
Abstract Introduction Despite the success of interventional processes such as drug-eluting stents, complete prevention restenosis is still hindered by impaired or delayed endothelialization both. Here, we report that 1 H -pyrrole-2,5-dione-based small molecule-generated mesenchymal stem cell-derived functional endothelial cells (MDFECs) facilitated rapid transmural coverage injured blood vessels. Methods Small molecules induced CD31 expression were screened principal component analysis...
Less than a year after the British occupation of Egypt in 1882, cholera struck late June 1883. The country experienced three subsequent epidemics 1895–6, 1902 and 1947. Over course these four epidemics, colonial government its agencies closed access to water resources, forcibly entered homes removed sick people from their families, ostensibly prevent spread disease. Concerns for public’s health served as convenient pretext practice emergency sanitary measures which were cheaper comprehensive...
Introduction: We present a case of multiple myeloma with amyloidosis, which has features peripheral neuropathy after induction chemotherapy before autologous blood stem cell transplantation, in 56-year-old woman Korean medicine.Case Presentation: For 17 days hospitalization, the patient complaints numbness and tingling sensation hands feet was treated acupuncture, herbal medicine. To reduce symptoms, we provided medicine treatments, including medicine, moxibustion. The Visual Analog Scale...
Several attempts have been made to reduce the harmful side effects and increase efficacy of current drugs used treat attention-deficit/hyperactivity disorder (ADHD). Many articles studied medicinal herbs as an effective supplement in treating ADHD. In a similar manner, this study provides foundational data identify that are potentially ADHD by text mining Donguibogam, which is comprehensive summation important traditional principles practices Korean medicine.
In Korea, low back pain is the ailment that most frequently treated using collaborative care regimens include aspects of Western and traditional Korean medicine. As part a national pilot project on collaboration between medicine, we aimed to investigate clinical effectiveness treatment compare it with methods involved only or Medicine practices for patients pain. This nationwide, multicenter, prospective, observational, comparative study spanned 8 weeks, during which were evaluated at three...