Abstract The anionic ring‐opening polymerizations of ( R , S )‐β‐butyrolactone and initiated with tetrabutylammonium salts carboxylic acids as initiators were investigated. Poly[( )‐3‐hydroxybutyrate] poly[( )‐3‐hydroxybutyrate], relatively high molecular weights (170,000 35,000, respectively) low weight distributions, synthesized. Moreover, biomimetic poly(3‐hydroxybutyrate)s well‐defined microstructures predictable iso‐dyad contents obtained. © 2002 Wiley Periodicals, Inc. J Polym Sci Part...

Oxide-polymer coatings were formed on the surface of vanadium-free Ti-15Mo titanium alloy. The Ti alloy was modified by plasma electrolytic oxidation process, and then, polymer layer a poly (D, l-lactide-co-glycolide) with doxycycline formed. evenly covered porous oxide filled some pores. However, microstructure completely different from that PEO layer. morphology, roughness examined scanning electron microscopy (SEM) confocal microscope. results confirmed effectiveness deposition in their...

This paper describes a formation of hybrid coatings on Ti-2Ta-3Zr-36Nb surface. is accomplished by plasma electrolytic oxidation and dip-coating technique with poly(adipic anhydride) ((C6H8O3)n) that loaded drugs: amoxicillin (C16H19N3O5S), cefazolin (C14H14N8O4S3) or vancomycin (C66H75Cl2N9O24 · xHCl). The characteristic microstructure the polymer was evaluated using scanning electron microscopy confocal microscopy. Depending surface treatment, roughness varied (between 1.53 μm 2.06 μm),...

Titanium (Ti) dental implants were anodized in calcium hypophosphite solution to obtain a porous, bioactive layer. The implant surface was covered by poly(sebacic anhydride) (PSBA) layer with amoxicillin. SEM analysis showed an irregular distribution of the antibiotic on surface. However, confocal microscopy images revealed formation uniform polymer thickness oxide and layers similar, between 6 9 μm. PSBA is easy, hydrolysable polymer. After amoxicillin immersed phosphate buffered (PBS) for...

Abstract Summary: New injectable, in situ curable liquid formulations consisting of biodegradable aliphatic polyester, i.e., poly(3‐allyloxy‐1,2‐propylene)succinate (PSAGE), methyl methacrylate (MMA), and hydrophilic oligo(ethylene glycol) dimethacrylates (OEGDMA) were investigated. The effect MMA/OEGDMA ratio, OEGDMA molecular weight, the length oligooxyethylene fragments, on maximum curing temperature, setting time, compressive strength modulus cured materials as well their hydrophilicity...

Vascular regeneration is a complex process, additionally limited by the low potential of blood vessels. Hence, current research focused on design artificial materials that combine biocompatibility with certain rate biodegradability and mechanical robustness. In this paper, we have introduced scaffold material made poly(L-lactide-co-glycolide)/poly(isosorbide sebacate) (PLGA/PISEB) fibers fabricated in course an electrospinning confirmed its towards human umbilical vein endothelial cells...

Abstract In the present work, deposition of poly(sebacic anhydride) PSBA loaded by amoxicillin, cefazolin, or vancomycin on a previously anodized Ti‐15Mo surface is presented. drug was deposited so as not to lose functionality porous oxide layer microstructure. The morphology evaluated using scanning electron microscopy, roughness, and wettability. concentration high‐performance liquid chromatography. It determined that drugs were into coatings in range 35.2–122.87 μg/cm 2 Ti sample....

In the present paper synthesis and selected properties of functional aliphatic poly(3-allyloxy-1,2-propylene succinate) (PSAGE) are described. This polyester was synthesized by melt co-polymerization succinic anhydride allyl glycidyl ether in presence benzyltrimethylammonium chloride as catalyst. The chain structure PSAGE its end-groups characterized MALDI-TOF mass spectrometry. It found that undergoes hydrolytic degradation phosphate buffer solution (pH 7.41) at 37 degrees C and,...

Abstract New biodegradable poly(3-allyloxy-1,2-propylene)succinate-based materials were obtained by cross-linking poly(3-allyloxy-1,2-propylene)succinate (PSAGE) with methyl methacrylate (MMA) and methacrylic anhydride (MAAH). The aim of this study was to examine the influence MAAH/MMA ratio incorporation biphasic calcium phosphate (BCP) filler on maximum curing temperature, setting time, compressive strength modulus cured materials, as well their hydrolytic degradation. latter characterized...

The paper is the second part of a review concerning polymeric systems formed at site application (in situ). following presentation relates to injectable hydrogel systems. Brief description polymers applied in such given. main strategies for preparing hydrogels target are also described. In situ gelling have been essentially classified into chemically and physically crosslinked ones.

In situ forming implants (ISFIs) appear to be a convenient drug delivery system, alternative conventional preformed and microparticles for parenteral applications. It has been shown that they offer several advantages including easy minimally invasive application, potential local/site‐specific allows reduction of side effects associated with systemic administration drug. A few ISFI formulations based on poly(α‐hydroxy acids), solidifying by solid phase separation, are currently commercially...

In this study new composite materials obtained by crosslinking two polyester resins were investigated. The solid material and the scaffolds with varied porosity in presence of a foaming system consisted calcium carbonate/citric acid mixture. It was found that citric solution influenced rheological behavior liquid formulations as well morphology mechanical properties cured materials. SEM observations analysis energy-dispersive X-ray dispersive spectroscopy confirmed hydroxyapatite formed at...

The paper is a literature review with 111 references on the polymeric implants forming in site of incorporation into organism. This kind materials may have only structural function, but they can also serve as carriers bioactive compounds treated site. In situ (ISFI) be obtained by reaction functional groups contained system components or result physical processes. ISFI serving injectable scaffolds intended for tissue regeneration and requirements that should fulfilled these are presented....

A short review with 41 references on new functional polyesters and poly(ester-anhydride) s based succinic acid is presented. The properties of poly(3-allyloxy-1,2-propylene succinate) its possible use as a component biodegradable bone cements are discussed. methods for the oxidation pendant allyl groups to other groups, including epoxy, formation polyester-epoxy resins potentially used in preparation implants, described. second part article concerns various synthetic available...

Abstract Polysuccinates with pendant allyl groups (PSAGE) were synthesized by melt copolymerization of succinic anhydride glycidyl ether and eventually other ethers. It was found that PSAGE could be crosslinked radical methyl methacrylate. Oxidized considered as multifunctional epoxy resin cured use glutaric to form solid material susceptible hydrolytic degradation water‐soluble non‐toxic products. Comb‐like amphiphilic polysuccinates containing both poly(oxyethylene) chains have been well...

Repair and regeneration of bone defects with particular shape may be enhanced by in situ forming biomaterials which can used minimal invasive surgery. This study is aimed to prepare novel biodegradable nanocomposites based on poly(3-allyloxy-1,2-propylene) succinate (PSAGE) nanosized hydroxyapatite (HA). These nanocomposite materials contain poly(ester-anhydride) (PEA) microspheres embedded a polyester matrix prepared crosslinking PSAGE oligo(1,2-propylene maleate) methacrylic monomers....

This study aimed to prepare novel biodegradable polymeric composites based on poly(3-allyloxy-1,2-propylene) succinate (PSAGE). These composite materials are composed of poly(ester-anhydride) (PEA) microspheres embedded in polyester matrix prepared by crosslinking PSAGE with oligo(1,2-propylene maleate) and methacrylic monomers. Methyl methacrylate one hydrophilic oligo(ethylene glycol) dimethacrytes different length oligooxyethylene chains were used as polymerizable solvents. Incorporation...

This literature review (112 references) concerns bioactive bone cements and biodegradable cement compositions. The materials showing biological activity due to inorganic fillers giving them osteoconductive properties, the with antibacterial properties containing various antibiotics were presented. Various methods of preparation reach optimal for either temporary filling tissue losses or reinforcement at places mechanical pathological injuries described. compositions systems based on...