A5056614949- Cholinesterase and Neurodegenerative Diseases
- Enzyme function and inhibition
- Natural Antidiabetic Agents Studies
- Piperaceae Chemical and Biological Studies
- Synthesis and Catalytic Reactions
- Synthesis and biological activity
- Chemical Reactions and Mechanisms
- Antimicrobial Peptides and Activities
- Phytochemistry and Bioactivity Studies
- Phytoestrogen effects and research
- Phytochemistry and Biological Activities
- Aldose Reductase and Taurine
- Alzheimer's disease research and treatments
- Cassava research and cyanide
- Healthcare and Venom Research
- Curcumin's Biomedical Applications
- Phytochemical compounds biological activities
- Pharmacological Effects of Natural Compounds
- Natural product bioactivities and synthesis
- Food composition and properties
- Traditional and Medicinal Uses of Annonaceae
- Insect and Pesticide Research
- Neuroinflammation and Neurodegeneration Mechanisms
- Cancer therapeutics and mechanisms
- Advanced Glycation End Products research
Kafrelsheikh University
2018-2023
University of Leeds
2021-2023
University of Bradford
2021
Mansoura University
2014-2017
Different 2,4-thiazolidinedione-tethered coumarins 5a-b, 10a-n and 11a-d were synthesised evaluated for their inhibitory action against the cancer-associated hCAs IX XII, as well physiologically dominant I II to explore selectivity. Un-substituted phenyl-bearing 10a, 10 h, 2-thienyl/furyl-bearing 11a-c exhibited best hCA (KIs between 0.48 0.93 µM) XII 0.44 1.1 actions. Interestingly, none of had any effect on off-target isoforms. The sub-micromolar compounds from biochemical assay, h 11a-c,...
Microbial Multidrug Resistance (MDR) is an emerging global crisis. Derivatization of natural or synthetic scaffolds among the most reliable strategies to search for and obtain novel antimicrobial agents treatment MDR infections. Here, we successfully manipulated synthetically flexible isatin moieties synthesize 22 thiazolyl-pyrazolines hybrids, assessed their potential activities in vitro against various pathogens, using broth microdilution calorimetric XTT reduction method. We chose 5...
In this work, the natural piperine moiety was utilised to develop two sets of piperine-based amides (5a-i) and ureas (8a-y) as potential anticancer agents. The action assessed against triple negative breast cancer (TNBC) MDA-MB-231, ovarian A2780CP hepatocellular HepG2 cell lines. particular, 8q stood out most potent anti-proliferative analogue TNBC MDA-MB-231 cells with IC50 equals 18.7 µM, which is better than that (IC50 = 47.8 µM) 5-FU 38.5 µM). Furthermore, investigated for its possible...
Acetylcholinesterase inhibitors (AChE-Is) increase both level and duration of action acetylcholine (ACh); thus, alleviate symptoms Alzheimer's disease (AD). Glycyrrhizin, is the main active compound in liquorice root. Its aglycone, glycyrrhetinic acid, has shown several beneficial pharmacological activities. This study reports synthesis screening a series acid analogs as AChE-Is. Fourteen derivatives were prepared, which five are recorded new viz., 3-phenyl-carbamoyl-18β-glycyrrhetinic (J9),...
Cancer is a large group of disorders characterized by uncontrolled cellular proliferation. It one the most devastating diseases all over world. Recently, there an increased interest in clinical use natural products as safe, efficient, and economic therapeutic alternative. Honey bee therapy, apitherapy, was used to control various including cancer. In this study, samples honey, venom propolis were collected from different Egyptian localities with techniques tested MTT cell-based assay against...
Aldose reductase (AR) has been the leading target in treatment of diabetic cataract. Although numerous synthetic AR inhibitors (ARI) have identified, their adverse side effects currently preclude use. Olive leaf extract (OLE) as well ginkgo (GLE) are natural supplements that wide therapeutic indices and a plethora salutary during diabetes so far untested on sugar cataract progression. As such, present study sought to evaluate AR-inhibiting properties OLE GLE using isolated enzyme from rabbit...
The major labdanes in the oleogum resin of Araucaria heterophylla (Salisb.) Franco, 13-epi-cupressic acid (1) and acetyl-13-epi-cupressic (2) were used to prepare seven new (3–9), along with one known (10) derivatives. RAW264.7 cells evaluate anti-inflammatory activity derivatives (1–10) via measuring level COX-2 expression IL-6. Pre-treated 1–10 (except for derivative 7) at 25 µM 24h exhibited downregulation response LPS stimulation. Moreover, pre-treatment compounds 1, 2, or 3...
Alzheimer’s disease (AD) is one of the major causes dementia and its incidence represents approximately 60–70% all cases worldwide. Many theories have been proposed to describe pathological events in AD, including deterioration cognitive function, accumulation β-amyloid, tau protein hyperphosphorylation. Infection as well various cellular molecules, such apolipoprotein, micro-RNA, calcium, ghrelin receptor, probiotics, are associated with disruption β-amyloid hemostasis. This review gives an...