A5075704073- Immune Response and Inflammation
- Sepsis Diagnosis and Treatment
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- IL-33, ST2, and ILC Pathways
- Immune responses and vaccinations
- Telomeres, Telomerase, and Senescence
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Asthma and respiratory diseases
- Cytokine Signaling Pathways and Interactions
- Extracellular vesicles in disease
- Influenza Virus Research Studies
- Immune cells in cancer
- Cancer-related molecular mechanisms research
- Thermal Regulation in Medicine
- Immune Cell Function and Interaction
- Diabetes and associated disorders
- Inflammation biomarkers and pathways
Medical University of Vienna
2021-2025
CeMM Research Center for Molecular Medicine
2021-2025
Austrian Academy of Sciences
2021-2025
University of Sheffield
2022
Abstract Immune cells need to sustain a state of constant alertness over lifetime. Yet, little is known about the regulatory processes that control fluent and fragile balance called homeostasis. Here we demonstrate JAK-STAT signaling, beyond its role in immune responses, major regulator cell We investigated JAK-STAT-mediated transcription chromatin accessibility across 12 mouse models, including knockouts all STAT factors TYK2 kinase. Baseline signaling was detected CD8 + T macrophages...
Pulmonary fibrosis is an incurable disease that manifests with advanced age. Yet, how hematopoietic aging influences immune responses and progression remains unclear. Using heterochronic bone marrow transplant mouse models, we found aged exacerbates lung irrespective of tissue Upon injury, there was increased accumulation monocyte-derived alveolar macrophages (Mo-AMs) driven by cell-intrinsic aging. These Mo-AMs exhibited enhanced profibrotic profile stalled maturation into a homeostatic,...
Environmental microbial triggers shape the development and functionality of immune system. Alveolar macrophages (AMs), tissue-resident lungs, are in constant direct contact with inhaled particles microbes. Such exposures likely impact AM reactivity to subsequent challenges by immunological imprinting mechanisms referred as trained immunity. Here, we investigated whether a ubiquitous compound has potential induce training vivo. We discovered that intranasal exposure ambient amounts...
Microbial exposure at barrier interfaces drives development and balance of the immune system, but consequences local infections for systemic immunity secondary inflammation are unclear. Here, we show that skin to bacterium Staphylococcus aureus persistently shapes system mice with specific impact on progenitor mature bone marrow neutrophil eosinophil populations. The infection-imposed changes in eosinophils were long-lasting associated functional as well imprinted epigenetic metabolic...
Lipocalin 2 (LCN2) is a secreted glycoprotein with roles in multiple biological processes. It contributes to host defense by interference bacterial iron uptake and exerts immunomodulatory functions various diseases. Here, we aimed characterize the function of LCN2 lung macrophages dendritic cells (DCs) using Lcn2-/- mice. Transcriptome analysis revealed strong LCN2-related effects CD103+ DCs during homeostasis, differential regulation antigen processing presentation antiviral immunity...
Sepsis is a life-threatening condition characterized by uncontrolled systemic inflammation and coagulation, leading to multiorgan failure. Therapeutic options prevent sepsis-associated immunopathology remain scarce. Here, we established mouse model of long-lasting disease tolerance during severe sepsis, manifested diminished immunothrombosis organ damage in spite high pathogen burden. We found that both neutrophils B cells emerged as key regulators tissue integrity. Enduring changes the...
Telomerase, the enzyme capable of elongating telomeres, is usually restricted in human somatic cells, which contributes to progressive telomere shortening with cell-division and ageing. T B-cells cells are that can break this rule modulate telomerase expression a homeostatic manner. Whereas it seems intuitive an immune cell type depends on regular proliferation outbursts for function may have evolved less obvious why others also do so, as has been suggested macrophages neutrophils some...
ABSTRACT Telomerase, the enzyme capable of elongating telomeres, is usually restricted in human somatic cells, which contributes to progressive telomere shortening with cell-division and ageing. Using zebrafish model, we show that subsets gut immune cells have telomerase-dependent “hyper-long” identified as being predominantly macrophages dendritics ( mpeg1 . 1 + cd45 mhcII ). Notably, mpeg much longer telomeres than their haematopoietic tissue origin, suggesting there a gut-specific...
Abstract Sepsis is a life-threatening condition characterized by uncontrolled systemic inflammation and coagulation, leading to multi-organ failure. Therapeutic options prevent sepsis-associated immunopathology remain scarce. Here, we established model of long-lasting disease tolerance during severe sepsis, manifested diminished immunothrombosis organ damage in spite high pathogen burden. We found that, both neutrophils B cells emerged as key regulators tissue integrity. Enduring changes the...