Lei Du

ORCID: 0000-0003-4685-6851
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About
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Research Areas
  • Genetic and phenotypic traits in livestock
  • Genetic Mapping and Diversity in Plants and Animals
  • Gut microbiota and health
  • Cancer-related molecular mechanisms research
  • Research in Cotton Cultivation
  • Diet and metabolism studies
  • Plant Disease Resistance and Genetics
  • Genetic diversity and population structure
  • Plant Molecular Biology Research
  • Clostridium difficile and Clostridium perfringens research
  • Insect-Plant Interactions and Control
  • Probiotics and Fermented Foods
  • Insect Resistance and Genetics
  • Advances in Cucurbitaceae Research
  • Agriculture, Soil, Plant Science
  • Fungal Plant Pathogen Control
  • Biofuel production and bioconversion
  • Botanical Studies and Applications
  • Microbial Community Ecology and Physiology
  • Plant Disease Management Techniques
  • Plant Parasitism and Resistance
  • Medical Research and Treatments
  • Insect Pheromone Research and Control
  • Plant Physiology and Cultivation Studies
  • Fatty Acid Research and Health

Peking University
2022-2024

Chongqing Academy of Animal Science
2016-2024

University of Chinese Academy of Sciences
2024

Shandong University
2023

Yuncheng University
2010-2022

Minzu University of China
2022

China Agricultural University
2021-2022

State Key Laboratory of Animal Nutrition
2022

Ministry of Ecology and Environment
2022

Huazhong Agricultural University
2020-2021

We report the genome sequence of melon, an important horticultural crop worldwide. assembled 375 Mb double-haploid line DHL92, representing 83.3% estimated melon genome. predicted 27,427 protein-coding genes, which we analyzed by reconstructing 22,218 phylogenetic trees, allowing mapping orthology and paralogy relationships sequenced plant genomes. observed absence recent whole-genome duplications in lineage since ancient eudicot triplication, our data suggest that transposon amplification...

10.1073/pnas.1205415109 article EN Proceedings of the National Academy of Sciences 2012-07-02

Abstract Cotton is an economically important crop throughout the world and a pioneer in salt stress tolerance research. Investigation of genetic regulation salinity will provide information for stress-resistant breeding. Here, we employed next-generation RNA-Seq technology to elucidate salt-tolerant mechanisms cotton using diploid species Gossypium davidsonii which has superior tolerance. A total 4744 5337 differentially expressed genes (DEGs) were found be involved roots leaves,...

10.1038/srep20582 article EN cc-by Scientific Reports 2016-02-03

Porcine diarrhea is a global problem that leads to large economic losses of the porcine industry. There are numerous factors related piglet diarrhea, and compelling evidence suggests gut microbiota vital host health. However, key bacterial differences between non-diarrheic diarrheic piglets not well understood. In present study, total 85 commercial at three pig farms in Sichuan Province Chongqing Municipality, China were investigated. To accomplish this, anal swab samples collected from...

10.1038/s41598-019-55328-y article EN cc-by Scientific Reports 2019-12-10

Clostridium sporogenes (C. sporogenes), as a potential probiotic, metabolizes tryptophan and produces an anti-inflammatory metabolite, indole-3-propionic acid (IPA). Herein, we studied the effects of C. its bioactive IPA, on skeletal muscle development chronic inflammation in mice. In vivo study, tissues serum samples mice with supplementation were used to analyze metabolism; IPA content was determined by metabonomics ELISA. vitro C2C12 cells exposed lipopolysaccharide (LPS) alone or LPS +...

10.3390/ijms222212435 article EN International Journal of Molecular Sciences 2021-11-18

Soil salinization is one of the major problems in global agricultural production. Cotton a pioneer crop with regard to salt stress tolerance, and can be used for saline-alkali land improvement. The large-scale detection tolerance traits cotton accessions, identification elite quantitative trait loci (QTLs)/genes salt-tolerance have been very important breeding. Here, 43 advanced salt-tolerant 31 highly salt-sensitive cultivars were detected by analyzing ten related 304 upland cultivars....

10.1371/journal.pone.0151076 article EN cc-by PLoS ONE 2016-03-04

Clubroot disease, caused by Plasmodiophora brassicae, is one of the most destructive soil-borne diseases in cruciferous crops worldwide. New strategies are urgently needed to control this as no effective disease-resistant varieties or chemical agents exist. Previously, we found that incidence rate and disease index clubroot oilseed rape decreased 50 40%, respectively, when was planted after soybean. In order understand how different rotation patterns affect occurrence rape, high-throughput...

10.1016/s2095-3119(20)63186-0 article EN cc-by-nc-nd Journal of Integrative Agriculture 2020-08-06

The change characteristics of intestinal microbial succession and the correlation with production two important types bacterial metabolites (short chain fatty acids bioamine) in piglets during early stage were fully explored this study. Six from different litters same birth time selected, weighted euthanized at 1, 7, 14, 21, 28, 35, 42 days age. During stage, grew quickly gradual increases blood levels growth hormone insulin, developmental index immunity. 16s rRNA analysis indicated alpha...

10.3389/fvets.2020.617259 article EN cc-by Frontiers in Veterinary Science 2021-01-05

Abstract Germ-free (GF) pigs have clear microbiological backgrounds, and are extensively used as large animal models in the biomedical sciences. However, investigations of transcriptomic differences between GF cesarean-derived conventional (CV) piglets limited. To improve our understanding pigs, to increase utility an alternative non-rodent model, we RNA sequencing profile gene expression five tissues (the oral mucosae, jejunum, colon, liver, spleen) four male CV from same litter. We...

10.1038/s41598-018-29093-3 article EN cc-by Scientific Reports 2018-07-10

ABSTRACT Gut bacteria belonging to the Clostridium family play a pivotal role in regulating host energy balance and metabolic homeostasis. As commensal bacterium, sporogenes has been implicated modulating homeostasis, albeit underlying mechanism remains elusive. Therefore, this study aimed investigate impact of C. supplementation on various physiological parameters, intestinal morphology, particularly adipose tissue accumulation, glucolipid metabolism mice. The findings reveal that mice...

10.1128/spectrum.04116-23 article EN cc-by Microbiology Spectrum 2024-06-25

Pelvic organ prolapse (POP) is a serious health issue that affects many adult women. Surgical treatments for POP patients comprise common strategy in which scaffold materials are used to reconstruct the prolapsed pelvic. However, existing pelvic reconstruction cannot meet clinical requirements terms of biocompatibility, mechanics and immunological rejection. To address these concerns, polypropylene (PP) mesh was selected because its strong mechanical properties. Small intestinal submucosa...

10.1177/0885328216628469 article EN Journal of Biomaterials Applications 2016-01-21

Summary The purpose of this study was to assess the genetic characteristics six breeds Chinese local sheep using 19 microsatellite loci and effectively validate statistical methods for individual assignment based on informative microsatellites. All deviated from Hardy–Weinberg equilibrium expectations, while majority markers complied. polymorphism information content (PIC) overall populations ranged 0.283 ( SRCRSP5 ) 0.852 OarVH72 ). Tibetan were most diverse population with highest mean...

10.1111/j.1365-2052.2011.02212.x article EN Animal Genetics 2011-06-07

In the field, maize flowering time and height traits are closely linked with yield, planting density, lodging resistance, grain fill. To explore genetic basis of in maize, we investigated six related traits, namely, days to anthesis (AD), silking (SD), anthesis–silking interval (ASI), plant (PH), ear (EH), EH/PH ratio (ER) two locations for years based on doubled haploid (DH) populations. Based high-density linkage maps, 12 22 quantitative trait loci (QTL) were identified, respectively,...

10.3390/plants10081585 article EN cc-by Plants 2021-07-31

With the prevalence of obesity and obesity-related metabolic syndrome, such as insulin resistance in recent years, it is urgent to explore effective interventions prevent progression syndrome. Palmitoleic acid a monounsaturated fatty that available from dietary sources, mainly derived marine products. plays positive role maintaining glucose homeostasis reducing inflammation. However, still unknow mechanism palmitoleic ameliorating resistance. Here, we investigated effects on chow diet...

10.26599/fshw.2022.9250073 article EN cc-by-nc-nd Deleted Journal 2023-04-14

The 7 sheep microsatellite markersOarFCB48, OarAE101, MAF33, OarFCB11, MAF70, OarFCB304 and OarFCB128, which were located on chromosomes 2, 4, 6, 9, 17 19, selected to PCR in Hu sheep, Tong their closely related species,the goat.They studied with the amplifying result of sites Sheep, Sheep goats, data allele number range allele's size analyzed ANOVA.The results showed that there no significant differences (p<0.05) DNA among 3 populations.Concerning conservation microsatellites species,...

10.5713/ajas.2004.583 article EN cc-by Asian-Australasian Journal of Animal Sciences 2004-01-01

Abstract As a potential prebiotic, soybean oligosaccharides (SBOS) can improve animal health by modulating gut microbiota. The aim of this study was to investigate the different effects supplementing SBOS and plus probiotic on growth pigs. Three groups growing pigs ( n = 12) were fed with basal diet (Control), + 0.5% (SBOS), or +0.5% 0.1% compound probiotics (SOP) for 42 days. Results showed that SOP treatments had positive in experiment, latter more effective. Compared control pigs, average...

10.1111/jpn.13782 article EN Journal of Animal Physiology and Animal Nutrition 2022-10-14
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