A5069586370- Science, Research, and Medicine
- Biotechnology and Related Fields
- Cardiac Arrest and Resuscitation
- Cardiac electrophysiology and arrhythmias
- Public Health Policies and Education
- Pharmaceutical Economics and Policy
- Receptor Mechanisms and Signaling
- Trauma and Emergency Care Studies
- Genomics and Chromatin Dynamics
- DNA and Nucleic Acid Chemistry
- Ethics and Legal Issues in Pediatric Healthcare
- HIV/AIDS drug development and treatment
- Artificial Intelligence in Healthcare and Education
- Biomedical Ethics and Regulation
- Food Security and Health in Diverse Populations
- Emergency and Acute Care Studies
- Hepatitis C virus research
- RNA and protein synthesis mechanisms
- Health Systems, Economic Evaluations, Quality of Life
- Biotin and Related Studies
- Trauma Management and Diagnosis
- Diffusion and Search Dynamics
- Cardiomyopathy and Myosin Studies
- Genetics, Bioinformatics, and Biomedical Research
- Academic Publishing and Open Access
Medical College of Wisconsin
2024-2025
Ovid Therapeutics (United States)
2016-2020
Biotechnology Innovation Organization
2020
Massachusetts General Hospital
2018-2019
Spaulding Rehabilitation Hospital
2019
Boston University
2019
Milford Hospital
2018
Massachusetts Eye and Ear Infirmary
2018
New York Proton Center
2014
Princeton University
2002
G protein-coupled receptor (GPCR) mediation of cardiac excitability is often overlooked in predicting the likelihood that a compound will alter repolarization. While areas GPCR signal transduction and electrophysiology are rich data, experiments combining two difficult. In silico modelling facilitates integration all relevant data both to explore hypothesis critical associations may exist between different signalling mechanisms An example this linkage suggested by observation mutation gene...
ABSTRACT When HeLa cells are lysed in solutions containing a non-ionic detergent and 0·75 M-NaCl, structures released that retain many of the morphological features nuclei. These nucleoids contain all nuclear DNA, RNA ‘core’ histones, but few other proteins characteristic chromatin. Their DNA is intact. The core histones dissociate on raising salt concentration. We have probed structure nucleoid-histone complexes using intercalating dye, ethidium, or polymerase Escherichia coli. Both higher...
ABSTRACT When HeLa cells are lysed in solutions containing a non-ionic detergent and 2 M-NaCl, structures released that retain many of the morphological features nuclei. These nucleoids contain all nuclear RNA DNA but few proteins characteristic chromatin. Their is supercoiled so intact. Using simple rapid procedure we have reconstructed nucleohistone complexes from ‘core’ histones without breaking DNA. We probed integrity structure using non-destructive fluorometric approach, which provides...
Periorbital burns can result in cicatricial healing and distortion of surrounding soft tissue, causing ectropion lagophthalmos. Severe ocular injury requires a multidisciplinary approach. We present our algorithm to restore vision 3 patients with burn related corneal blindness where allograft is expected fail due limbal stem cell damage, both eyes are blind but light perception 1 eye. In such cases, prosthesis (keratoprosthesis-KP), consisting donor tissue secured polymethylmethacrylate...