A5079228289- Intracranial Aneurysms: Treatment and Complications
- Cerebrovascular and Carotid Artery Diseases
- Vascular Malformations Diagnosis and Treatment
- Traumatic Brain Injury and Neurovascular Disturbances
- Neurosurgical Procedures and Complications
- Moyamoya disease diagnosis and treatment
- Cerebral Venous Sinus Thrombosis
- Cerebrospinal fluid and hydrocephalus
- Peripheral Artery Disease Management
- Coronary Interventions and Diagnostics
- Cardiovascular Health and Disease Prevention
- Glioma Diagnosis and Treatment
- Oropharyngeal Anatomy and Pathologies
- Meningioma and schwannoma management
- Autophagy in Disease and Therapy
- Aortic Disease and Treatment Approaches
- Organ Transplantation Techniques and Outcomes
- Trace Elements in Health
- Innovative Microfluidic and Catalytic Techniques Innovation
- Endoplasmic Reticulum Stress and Disease
- Neuroscience of respiration and sleep
- Vascular Procedures and Complications
- Neurological Disease Mechanisms and Treatments
- Neonatal and fetal brain pathology
- Fetal and Pediatric Neurological Disorders
Kanazawa Medical University
2023-2024
Kanazawa University
2012-2023
Stony Brook University
2021
Neurological Surgery
2021
Shinshu University
2021
Oxford University Press (United Kingdom)
2020
Fukui Prefectural Hospital
2016-2017
Oxytocin sets the stage for childbirth by initiating uterine contractions, lactation and maternal bonding behaviours. Mice lacking secreted oxcytocin (Oxt-/-, Cd38-/-) or its receptor (Oxtr-/-) fail to nurture. Normal behaviour is restored peripheral replacement in Oxt-/- Cd38-/-, but not Oxtr-/- mice, implying that circulating crosses blood-brain barrier. Exogenous also has behavioural effects humans. However, polypeptides are typically excluded from brain. We show transported into brain...
Abstract To dissect the role of endoplasmic reticulum (ER) stress and unfolded protein response in brain ischemia, we investigated relevance activating transcription factor 6α (ATF6α), a master transcriptional response, after permanent middle cerebral artery occlusion (MCAO) mice. Enhanced expression glucose‐regulated protein78, downstream molecular chaperone ATF6α, was observed both neurons glia peri‐infarct region wild‐type mice MCAO. Analysis using Atf6 α −/− revealed larger infarct...
Abstract Disruption of the blood‐brain barrier (BBB) following cerebral ischemia is closely related to infiltration peripheral cells into brain, progression lesion formation, and clinical exacerbation. However, mechanism that regulates BBB integrity, especially after permanent ischemia, remains unclear. Here, we present evidence astrocytic N‐myc downstream‐regulated gene 2 (NDRG2), a differentiation‐ stress‐associated molecule, may function as modulator permeability ischemic stroke, using...
Although early brain injury (EBI) is recognized as a critical step following subarachnoid hemorrhage (SAH), its pathophysiology and underlying mechanisms remain poorly understood. Herein, we investigated the role of cerebral circulation in acute phase using patient data mouse SAH model evaluated regulation via sympathetic nervous system.The time neurological outcomes human body were retrospectively examined 34 cases with ruptured anterior aneurysms 85 unruptured at Kanazawa University...
Although the inflow hemodynamics of cerebral aneurysms are key factors in their rupture and recurrence after endovascular treatments, most available method for evaluation remains unestablished. We compared efficacy using computational fluid dynamics (CFD) analysis that four-dimensional (4D) flow magnetic resonance imaging (MRI).In 23 unruptured aneurysms, was evaluated both CFD 4D MRI. The parameters included visually classified jet patterns, rate ratio (the at aneurysmal orifice to proximal...
Extracranial internal carotid artery aneurysms (EICAs) are rare. Although a high mortality risk has been reported in nonoperated cases, the optimal treatment for EICAs remains unknown.
The increased surface pressure of the coil mass calculated by computational fluid dynamics (CFD) analysis has been reported to be associated with recurrence internal carotid aneurysms after embolization. In this study, we investigated relationship between on and anterior communicating aneurysms.Among patients who underwent embolization at a volume rate 20% or more without using stent, only one proximal artery (A1) was visualized magnetic resonance angiography (MRA). A virtual post-coiling...
Abstract Background Meningiomas and unruptured cerebral aneurysms (UCAs) rarely coexist. However, the treatment strategy remains to be fully elucidated. This report is a first that UCA related tumor feeder intraoperatively ruptured when meningioma was resected. Case presentation Herein, we present case of coexisting with contralateral feeder. Immediately after resected, intraoperative acute brain swelling due rupture aneurysm appeared. The swollen protruding into epidural space following...
Abstract Purpose A previous study on computational fluid dynamics reported that a high pressure difference (PD) at the surface of coil mass is strong predictor aneurysm recurrence after embolization. PD was calculated using virtual post-coiling model (VM), created by manually cutting flat plane from an anatomic with pre-coil embolization data; however, its credibility has not been fully evaluated. This aims to clarify whether values model, which reflects actual plane, are recurrence. Methods...
Arachnoid cysts (ACs) are congenital anomalies of the central nervous system and arise in virtually all locations where arachnoid membrane exists. Posterior fossa ACs considered to develop posterior aspect rhombencephalic roof plate do not communicate freely with fourth ventricle or perimedullary subarachnoid space. Although have been reported a number times, arising from foramen Magendie very rare.We report here on 76-year-old female who presented progressive gait disturbance. Magnetic...
Dural arteriovenous fistulas (dAVFs) occurring near the hypoglossal canal are rare. Detailed evaluation of vascular structures can identify shunt pouches at jugular tubercle venous complex (JTVC) in bone canal. Although JTVC has several connections, including canal, there have been no reports transvenous embolization (TVE) a dAVF using an approach route other than This report describes first case complete occlusion with targeted TVE alternative 70-year-old woman presenting tinnitus diagnosed...
Although bleb formation increases the risk of rupture intracranial aneurysms, previous computational fluid dynamic (CFD) studies have been unable to identify robust causative hemodynamic factors, due morphological differences prebleb aneurysm models and a small number aneurysms with de novo formation. This study investigated influences in aneurysm-models factors for formation.CFD analysis was conducted on three models, actual prebleb, postbleb, virtual two unruptured A new multipoint method...
Introduction Hemorrhage from a recurrent aneurysm is major concern after coiling for intracranial aneurysms. We aimed to identify recurrence patterns associated with hemorrhage. Material and methods investigated radiological data of patients who underwent aneurysms in 2008–2016 were followed-up at least 6 months. Aneurysm classified as: type Ⅰ, enlargement neck; Ⅱ, cavity within the coil mass; Ⅲ, along wall; Ⅳ, formation daughter sac. evaluated incidence various or without Results Of 173...
Excellent treatment outcomes using a pipeline embolization device (PED) have been reported. However, several limitations exist. For example, patients must receive antiplatelet therapy for at least months, and few alternative treatments exist except inserting additional flow diverter stents in cases where aneurysm obliteration is not obtained.A 67-year-old female suffered from an asymptomatic large of the left paraclinoid internal carotid artery (ICA). She underwent endovascular coil...
Posterior cerebral artery (PCA) aneurysms are relatively rare. PCA tend to be large, giant, fusiform, and partially thrombosed. Surgical treatments, such as neck clipping trapping with or without bypass surgery, curative treatments for thrombosed intracranial aneurysms. Few cases of surgical treatment distal have been reported. We treated a aneurysm by through the occipital transtentorial approach (OTA) assisted endovascular coil embolization.A 21-year-old woman presented sudden headache....
Background: Treatment of cervical internal carotid artery (ICA) stenosis has contributed to the improvement ocular ischemic syndrome. However, there have been few cases visual impairment caused by syndrome due intracranial ICA stenosis, which improved through stent placement. Case Description: A 76-year-old man presented with right-sided paralysis. Radiographic examination revealed severe left (distal cavernous-infraclinoid portion) and a watershed infarction cerebral hemisphere....
Objective Cerebral vasospasm complicates the treatment of aneurysmal subarachnoid hemorrhage, and optimal timing surgery for ruptured intracranial aneurysm diagnosed during cerebral period has been a matter debate. This study aimed to clarify differences in endovascular outcomes between intervention spasm nonspasm. Methods Materials We retrospectively reviewed 68 consecutive patients with aneurysms who underwent coil embolization January 2016 March 2021. Clinical presentations, radiographic...