A5055351138- Intracranial Aneurysms: Treatment and Complications
- Cerebrovascular and Carotid Artery Diseases
- Traumatic Brain Injury and Neurovascular Disturbances
- Vascular Malformations Diagnosis and Treatment
- Moyamoya disease diagnosis and treatment
- Neurosurgical Procedures and Complications
- Acute Ischemic Stroke Management
- Intracerebral and Subarachnoid Hemorrhage Research
- Meningioma and schwannoma management
- Cerebral Venous Sinus Thrombosis
- Glioma Diagnosis and Treatment
- Spinal Fractures and Fixation Techniques
- Neurological Complications and Syndromes
- Cerebrospinal fluid and hydrocephalus
- Aortic Disease and Treatment Approaches
- Cardiovascular Health and Disease Prevention
- Brain Metastases and Treatment
- Epilepsy research and treatment
- Vascular Procedures and Complications
- Takotsubo Cardiomyopathy and Associated Phenomena
- Peripheral Artery Disease Management
- Head and Neck Surgical Oncology
- Cardiac and Coronary Surgery Techniques
- Advanced MRI Techniques and Applications
- Coronary Interventions and Diagnostics
Kanazawa University
2016-2025
Kyoto University
2024
Kanazawa Municipal Hospital
2023
Saitama Medical University
2018-2022
Yokohama Sakae Kyosai Hospital
2014-2022
Neurological Surgery
2017-2021
Shinshu University
2021
Stony Brook University
2021
Oxford University Press (United Kingdom)
2020
Barrow Neurological Institute
2018-2019
Oxytocin sets the stage for childbirth by initiating uterine contractions, lactation and maternal bonding behaviours. Mice lacking secreted oxcytocin (Oxt-/-, Cd38-/-) or its receptor (Oxtr-/-) fail to nurture. Normal behaviour is restored peripheral replacement in Oxt-/- Cd38-/-, but not Oxtr-/- mice, implying that circulating crosses blood-brain barrier. Exogenous also has behavioural effects humans. However, polypeptides are typically excluded from brain. We show transported into brain...
Abstract To dissect the role of endoplasmic reticulum (ER) stress and unfolded protein response in brain ischemia, we investigated relevance activating transcription factor 6α (ATF6α), a master transcriptional response, after permanent middle cerebral artery occlusion (MCAO) mice. Enhanced expression glucose‐regulated protein78, downstream molecular chaperone ATF6α, was observed both neurons glia peri‐infarct region wild‐type mice MCAO. Analysis using Atf6 α −/− revealed larger infarct...
OBJECTIVEWhile most paraclinoid aneurysms can be clipped with excellent results, new postoperative visual deficits are a concern. New technology, including flow diverters, has increased the popularity of endovascular therapy. However, treatment is not without procedural risks, associated higher rates incomplete aneurysm occlusion and recurrence, may address optic nerve compression symptoms that surgical debulking can. The increasing management should justified by comparisons to benchmarks....
Abstract While autonomic dysregulation and repolarization abnormalities are observed in subarachnoid hemorrhage (SAH), their relationship remains unclear. We aimed to measure skin sympathetic nerve activity (SKNA), a novel method estimate stellate ganglion activity, investigate its association with electrocardiogram (ECG) alterations after SAH. recorded total of 179 SKNA data from SAH patients at three distinct phases compared them 20 controls. Compared control data, the acute phase (days...
Abstract Disruption of the blood‐brain barrier (BBB) following cerebral ischemia is closely related to infiltration peripheral cells into brain, progression lesion formation, and clinical exacerbation. However, mechanism that regulates BBB integrity, especially after permanent ischemia, remains unclear. Here, we present evidence astrocytic N‐myc downstream‐regulated gene 2 (NDRG2), a differentiation‐ stress‐associated molecule, may function as modulator permeability ischemic stroke, using...
Although early brain injury (EBI) is recognized as a critical step following subarachnoid hemorrhage (SAH), its pathophysiology and underlying mechanisms remain poorly understood. Herein, we investigated the role of cerebral circulation in acute phase using patient data mouse SAH model evaluated regulation via sympathetic nervous system.The time neurological outcomes human body were retrospectively examined 34 cases with ruptured anterior aneurysms 85 unruptured at Kanazawa University...
Abstract BACKGROUND Microsurgical clipping of paraclinoid aneurysms presents unique technical challenges because the anatomical complexity region. OBJECTIVE To analyze microsurgical techniques, complications, and outcomes associated with aneurysms, a focus on clip selection technique according to aneurysm location. METHODS From 1997 2016, 231 unruptured from 216 patients were treated using clipping. We retrospectively reviewed patient records clinical outcomes. RESULTS A total 80 (34.6%)...
Hypertension is the prime risk factor for stroke, and primary aldosteronism (PA) most common cause of secondary hypertension. The prevalence PA in stroke patients has never been reported. aim this study was to elucidate PA. A total 427 consecutive with acute were prospectively enrolled study. screening tests performed at initial visit a week after admission by measuring plasma aldosterone concentration renin activity. rapid adrenocorticotropic hormone (ACTH) test as confirmatory when both...
Cavernous sinus (CS) dural arteriovenous fistula (dAVF) patients presenting with only headache as an initial symptom are not common. Patients CS-dAVF commonly present symptoms related to their eyes. In all three patients, was the symptom. Other eyes developed 1 - 7 months after headache. one patient, controlled by sumatriptan succinate, but diclofenac sodium or loxoprofen sodium. another third improved stellate ganglion block. magnetic resonance angiography (MRA) in early stage of clinical...
Although the inflow hemodynamics of cerebral aneurysms are key factors in their rupture and recurrence after endovascular treatments, most available method for evaluation remains unestablished. We compared efficacy using computational fluid dynamics (CFD) analysis that four-dimensional (4D) flow magnetic resonance imaging (MRI).In 23 unruptured aneurysms, was evaluated both CFD 4D MRI. The parameters included visually classified jet patterns, rate ratio (the at aneurysmal orifice to proximal...