A5016591402- Salivary Gland Disorders and Functions
- Immune Cell Function and Interaction
- Liver Diseases and Immunity
- Vasculitis and related conditions
- Diabetes and associated disorders
- Oral Health Pathology and Treatment
- Liver physiology and pathology
- MicroRNA in disease regulation
- T-cell and B-cell Immunology
- Cancer-related molecular mechanisms research
- Salivary Gland Tumors Diagnosis and Treatment
- Protein Tyrosine Phosphatases
- Circular RNAs in diseases
- Systemic Lupus Erythematosus Research
- Organ Transplantation Techniques and Outcomes
- Systemic Sclerosis and Related Diseases
- Traditional Chinese Medicine Studies
- Immunodeficiency and Autoimmune Disorders
- Drug Transport and Resistance Mechanisms
- Eosinophilic Disorders and Syndromes
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Mesenchymal stem cell research
- Extracellular vesicles in disease
- Galectins and Cancer Biology
- Eosinophilic Esophagitis
Peking Union Medical College Hospital
2020-2025
Chinese Academy of Medical Sciences & Peking Union Medical College
2020-2025
Ministry of Education of the People's Republic of China
2020-2021
National Clinical Research
2021
Background Primary Sjögren’s syndrome (pSS) is a systemic autoimmune disease characterised by aberrant B cell hyperactivation, whose mechanism partially understood. Methods We performed whole transcriptome sequencing of cells from three pSS patients and matched healthy controls (HC). Differentially expression genes (DEGs) were confirmed with 40 HC quantitative PCR western blot. measured the proliferation potential immunoglobulins production siRNA-transfected or plasmid-transfected stimulated...
About one-third of primary biliary cholangitis (PBC) patients do not exhibit complete response to ursodeoxycholic acid (UDCA). Some these were reported benefit from the combination therapy fibrates and UDCA, but more clinical evidence is required. In this study, we conducted a randomized, controlled trial on safety efficacy fenofibrate in treatment with PBC.Forty-eight PBC incomplete UDCA enrolled randomly assigned two groups (24 experiment group 24 control group). For experimental group,...
Enhancer of zeste homolog 2 (EZH2) is an epigenetic regulator that plays essential role in immune system development and autoimmune diseases. This study aimed to characterize the EZH2 pathogenesis primary Sjögren's syndrome (pSS). We analyzed expression two transcriptomic datasets peripheral blood mononuclear cells (PBMCs) from pSS patients healthy controls. measured CD4+ T cells, CD8+ CD19+ B controls correlated with clinical parameters. also examined activation, proliferation, T-cell...
Severe gastrointestinal lesions are associated with a poor prognosis in eosinophilic granulomatosis polyangiitis (EGPA). The goal of this study was to develop an effective predictive model for and examine clinical patterns, factors, treatment, outcomes EGPA. We retrospectively enrolled 165 EGPA patients. independent factors were analyzed using multivariate logistic regression. A nomogram conducted quantify the factors. correlation between different organ calculated explore patterns. total 52...
Mesenchymal stem cell (MSC) senescence is a phenotype of aging. Long noncoding RNAs (lncRNAs) are emerging as potential key regulators senescence. However, the role lncRNAs in MSC remains largely unknown.We performed transcriptome analysis senescent human adipose-derived MSCs (hADSCs) and identified that lncRNA LYPLAL1 antisense RNA1 (LYPLAL1-AS1) was significantly downregulated hADSCs. LYPLAL1-AS1 expression peripheral blood lower middle-aged healthy donors than young adult donors,...
To investigate the long-term survival of patients with primary Sjögren's syndrome (pSS) in China.Patients pSS who fulfilled 2002 American-European Consensus Group classification criteria were prospectively enrolled from 2004 to 2011. Their baseline clinical, laboratory, and therapeutic data collected. The endpoint was all-cause death by January 2018. standard mortality ratio (SMR) calculated comparing age-matched sex-matched general population. Kaplan-Meier curves obtained time-to-event...
Iguratimod (IGU) reduces hypergammaglobulinemia and disease activity in pSS (primary Sjögren's syndrome) patients. However, the therapeutical mechanism of IGU for remains largely unknown. This study aimed to investigate regulation Tfh cell differentiation by patients.We prospectively enrolled 13 patients treated with 3 months examined circulating T B subsets flow cytometry. We measured healthy controls. Transcriptome analysis combined molecular docking were employed identify potential...
Objectives: To explore the potential role of CD3+CD8+CD161high TCRVα7.2+ mucosal-associated invariant T (MAIT) cells in pathogenesis primary biliary cholangitis (PBC). Methods: We enrolled 55 patients with PBC, 69 healthy controls (HCs), and 8 hepatic hemangioma. Circulating MAIT their chemokine receptor profiles cytokine production were quantified using flow cytometry. Liver-resident examined by immunofluorescence staining. CXCL12-mediated chemotaxis was measured a transwell migration...
Abstract Objectives Whether naive CD4+ T cells are dysregulated and associated with the overactivation of in primary SS (pSS) remains unclear. We aimed to explore role underlying mechanism pSS. Methods examined activation, proliferation differentiation from pSS patients healthy controls. Differentially expressed genes were identified using RNA sequencing, overexpressed or silenced determine gene regulating follicular helper (Tfh) cells. Assay for transposase-accessible chromatin...