A5101751281- Reproductive Biology and Fertility
- Ovarian function and disorders
- Reproductive System and Pregnancy
- Assisted Reproductive Technology and Twin Pregnancy
- Reproductive Health and Technologies
- Sperm and Testicular Function
- Cancer-related molecular mechanisms research
- Ovarian cancer diagnosis and treatment
- Birth, Development, and Health
- MicroRNA in disease regulation
- Prenatal Screening and Diagnostics
- Kruppel-like factors research
- Mitochondrial Function and Pathology
- Soil Carbon and Nitrogen Dynamics
- Circular RNAs in diseases
- Pharmacological Effects and Assays
- Molecular Biology Techniques and Applications
- Estrogen and related hormone effects
- Cytokine Signaling Pathways and Interactions
- Toxin Mechanisms and Immunotoxins
- Endometriosis Research and Treatment
- Pesticide Residue Analysis and Safety
- Soil and Water Nutrient Dynamics
- Ectopic Pregnancy Diagnosis and Management
- Endometrial and Cervical Cancer Treatments
Zhongshan Hospital
2015-2025
Fudan University
2015-2025
State Key Laboratory of Medical Neurobiology
2025
Shanghai Medical College of Fudan University
2024
Shenyang Agricultural University
2022-2023
Ministry of Agriculture and Rural Affairs
2022-2023
Peking Union Medical College Hospital
2021-2022
Chinese Academy of Medical Sciences & Peking Union Medical College
2021-2022
Shanghai University of Traditional Chinese Medicine
2021
Shanghai Tenth People's Hospital
2021
To reveal the relationship between mitochondrial function in cumulus cells (CCs) and aging-related decline ovarian reproductive capacity.Retrospective transcriptome analysis of human tissue.University hospital.A total 186 infertile women with normal weight no other diseases, including 86 young (aged <38 years) reserve 100 advanced-age ≥38 diminished reserve.None.Embryo development data were analyzed. The ultrastructure CCs was observed by transmission electron microscopy. Mitochondrial...
Abstract Background Polycystic ovary syndrome (PCOS) is an endocrine and metabolic disorder with various manifestations complex etiology. Follicular fluid (FF) serves as the microenvironment for follicular development. However, correlation between concentration of steroid in FF pathogenesis PCOS still unclear. Methods Twenty levels from ten patients women male-factor infertility undergoing vitro fertilization were tested by liquid chromatography-tandem mass spectrometry (LC-MS/MS) order to...
Polycystic ovary syndrome (PCOS) is a common endocrine disorder in women of reproductive age, and oocyte developmental competence altered patients with PCOS. In recent years microRNAs (miRNAs) have emerged as important regulators gene expression, the aim study was to miRNAs expression patterns cumulus cells from PCOS patients. The included 20 undergoing vitro fertilization (IVF) intra-cytoplasmic sperm injection (ICSI): 10 diagnosed matching controls. We used deep sequencing technology...
ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTAntitumor Agents, 107. New Cytotoxic 4-Alkylamino Analogues of 4'-Demethyl-Epipodophyllotoxin as Inhibitors Human DNA Topoisomerase IIKuo-Hsiung Lee, Yasuhiro Imakura, Mitsumasa Haruna, Scott A. Beers, Lee S. Thurston, Hua-Juan Dai, Chung-Hsiung Chen, Su-Ying Liu, and Yuing-Chi ChengCite this: J. Nat. Prod. 1989, 52, 3, 606–613Publication Date (Print):May 1, 1989Publication History Published online1 July 2004Published inissue 1 May...
Abstract Context Androgen excess is a key feature of polycystic ovary syndrome (PCOS), but the underlying molecular mechanism remains unclear. Objective To determine role and novel long noncoding RNA (lncRNA) highly up-regulated in PCOS (HUPCOS) androgen patients. Design The lncRNA expression profile granulosa cells derived from non-PCOS women were analyzed by using microarray assay. Human cell line KGN was used for investigation. Setting This university-based study. Patients Thirty-eight 38...
This study was implemented to address the role of Roflumilast in polycystic ovary syndrome (PCOS) as well discuss its reaction mechanism vivo and vitro. In vivo, mice were administrated with 6 mg dehydroepiandrosterone (DHEA) per 100 g body weight fed 60% high fat diet induce PCOS. The expression phosphodiesterases 4 (PDE4) assessed RT-qPCR. pathology observed by hematoxylin eosin staining follicles counted. Enzyme-linked immunosorbent assay adopted for estimation progesterone, testosterone...
Abstract STUDY QUESTION What are the differences in gene expression of cumulus cells (CCs) between young women with diminished ovarian reserve (DOR) and those similar age normal (NOR)? SUMMARY ANSWER Gene metabolome profiling analysis demonstrate that de novo serine synthesis pathway (SSP) is increased CCs DOR. WHAT IS KNOWN ALREADY The incidence DOR has risen, tending to present at younger ages. Its mechanisms aetiologies still poorly understood. Abnormal metabolism luteinized patients...
Abstract Cervical human papillomavirus (HPV) infection is believed to increase the risks of pregnancy failure and abortion, however, whether uterine cavity HPV reduces rate or increases miscarriage remains unclarified in infertile women undergoing assisted reproductive technology (ART) treatment. Therefore, we aimed assess ART outcomes presence intrauterine HPV. This was a hospital‐based multicenter (five medicine centers) matched cohort study. study involved 4153 vitro fertilization (IVF)...
Advanced-age women have a lower good-quality embryo rate (GQER) compared to young women. However, GQER varies widely within the same age group, suggesting that factors beyond influence quality. Mitochondria regulate cellular metabolism through dynamic fission and fusion alterations. Specifically, cumulus cell (CC) mitochondria not only of CCs but also adjacent oocytes. This study aims investigate relationship between CC mitochondrial dynamics oocyte developmental potential...
Purpose Human follicular fluid (FF) is a complex biological that contributes to the micro-environment of oocyte development. The aim this study was evaluate role steroid and gonadotropic hormones levels mitochondrial function in embryo development during vitro fertilization cycles. Methods This cohort 138 women receiving IVF/ICSI, including 136 FF samples from 109 infertile women. were tested by liquid chromatography-tandem mass spectrometry (LC-MS/MS) immunoassays. mRNA expression electron...
This study was designed to investigate the association between nutrients and female infertility.A cross-sectional on 18-45 years of age reproductive-age women conducted using data from National Health Nutrition Examination Surveys (NHANES) for periods 2013-2014 2015-2016. Multivariate logistic regression analysis performed evaluate infertility. Subgroup applied body mass index (BMI). Results were summarised an odds ratio (OR) with a 95% confidence interval (CI).Of total 1713 women, 204...
Accumulating evidence revealed that the leading risk factor of endometrial cancer is exposure to endogenous and exogenous estrogens, while exact mechanism underlying estrogen contribution progression has not been elucidated clearly. Interleukin (IL)-6 verified be critical for tumor in several human cancers. In this study, we provided 17β-estradiol (E2) could significantly promote cells viability, migration invasion through activation IL-6 pathway, which involved its downstream pathway target...
Mesenchymal stem cell (MSC) senescence is a phenotype of aging. Long noncoding RNAs (lncRNAs) are emerging as potential key regulators senescence. However, the role lncRNAs in MSC remains largely unknown.We performed transcriptome analysis senescent human adipose-derived MSCs (hADSCs) and identified that lncRNA LYPLAL1 antisense RNA1 (LYPLAL1-AS1) was significantly downregulated hADSCs. LYPLAL1-AS1 expression peripheral blood lower middle-aged healthy donors than young adult donors,...
Previous studies have demonstrated that progestin-primed ovarian stimulation (PPOS) protocol was a feasible and efficient method in vitro fertilization (IVF) cycle. However, its application women with advanced age has not been determined yet. The purpose of this study to investigate efficacy aged ≥40 years old.This retrospective cohort included patients ages old at the time stimulation. embryonic clinical outcome mild PPOS were compared. Primary top-quality embryo rate on day 3, secondary...