A5060071842- Forensic and Genetic Research
- Genetic diversity and population structure
- Evolution and Paleontology Studies
- Primate Behavior and Ecology
- Race, Genetics, and Society
- Global Maritime and Colonial Histories
- Genomics and Phylogenetic Studies
- Morphological variations and asymmetry
- Forensic Anthropology and Bioarchaeology Studies
- Pleistocene-Era Hominins and Archaeology
- Amphibian and Reptile Biology
- Cognitive Abilities and Testing
- Neuroscience and Neuropharmacology Research
- 3D Shape Modeling and Analysis
- Genetics, Bioinformatics, and Biomedical Research
- Bat Biology and Ecology Studies
- Asian Geopolitics and Ethnography
- Genomics and Chromatin Dynamics
- Digestive system and related health
- Chromosomal and Genetic Variations
- Virus-based gene therapy research
- Neurogenesis and neuroplasticity mechanisms
- Demographic Trends and Gender Preferences
- Neuroinflammation and Neurodegeneration Mechanisms
- Yersinia bacterium, plague, ectoparasites research
Lehman College
2009-2023
City University of New York
2009-2023
The Graduate Center, CUNY
2009-2023
New York Consortium in Evolutionary Primatology
2006-2023
Rockefeller University
2013
University of Florida
2007
New York University
2004-2006
SummaryDifferentiated cells possess a remarkable genomic plasticity that can be manipulated to reverse or change developmental commitments. Here, we show the leprosy bacterium hijacks this property reprogram adult Schwann cells, its preferred host niche, stage of progenitor/stem-like (pSLC) mesenchymal trait by downregulating cell lineage/differentiation-associated genes and upregulating mostly mesoderm development. Reprogramming accompanies epigenetic changes renders infected highly...
Genetic studies have identified substantial non-African admixture in the Horn of Africa (HOA). In most recent genomic studies, this ancestry has been attributed to with Middle Eastern populations during last few thousand years. However, mitochondrial and Y chromosome data are suggestive earlier episodes admixture. To investigate further, we generated new genome-wide SNP for a Yemeni population sample merged these published genetic from HOA broad selection surrounding populations. We used...
Abstract The urban peoples of the Swahili coast traded across eastern Africa and Indian Ocean were among first practitioners Islam sub-Saharan people 1,2 . extent to which these early interactions between Africans non-Africans accompanied by genetic exchange remains unknown. Here we report ancient DNA data for 80 individuals from 6 medieval modern ( ad 1250–1800) coastal towns an inland town after 1650. More than half many originates primarily female ancestors Africa, with a large...
The earliest Neotropical primate fossils complete enough for taxonomic assessment, Dolichocebus, Tremacebus, and Chilecebus, date to approximately 20 Ma. These have been interpreted as either closely related extant forms or extinct stem lineages. former hypothesis of morphological stasis requires most living platyrrhine genera diverged before To test this hypothesis, we collected new mitochondrial genomes from Aotus lemurinus, Saimiri sciureus, Saguinus oedipus, Ateles belzebuth, Callicebus...
The methods of geometric morphometrics are commonly used to quantify morphology in a broad range biological sciences. application these large datasets is constrained by manual landmark placement limiting the number landmarks and introducing observer bias. To move field forward, we need automate morphological phenotyping ways that capture comprehensive representations variation with minimal Here, present Morphological Variation Quantifier (morphVQ), shape analysis pipeline for quantifying,...
In comparison with other primate species, humans have an extended juvenile period during which the brain is more plastic. current study we sought to examine gene expression in cerebral cortex development context of this adaptive plasticity. We introduce approach designed discriminate genes variable as opposed uniform patterns and found that greater inter-individual variance observed among children than adults. For 337 transcripts show pattern, a significant overrepresentation annotated...
Abstract Background Differentiating genetically between populations is valuable for admixture and population stratification detection in understanding history. This easy to achieve major continental populations, but not closely related populations. It has been claimed that a large marker panel necessary reliably distinguish within continent. We investigated whether empirical genetic differentiation could be accomplished efficiently among three Asian (Hmong, Thai, Chinese) using small set of...
It is difficult to predict how current climate change will affect wildlife species adapted a tropical rainforest environment. Understanding population dynamics fluctuated in such throughout periods of past climatic can provide insight into this issue. The drill (Mandrillus leucophaeus) large-bodied mammal found West Central Africa. In the middle endangered monkey's geographic range Lake Barombi Mbo, which has well-documented palynological record environmental that dates Late Pleistocene. We...
Southern Arabia and the Horn of Africa are important geographic centers for study human population history because a great deal migration has characterized these regions since first emergence humans out Africa. Analysis Jewish groups provides unique opportunity to investigate more recent histories in this area. Mitochondrial DNA is used maternal evolutionary can be combined with historical linguistic data test various histories. In study, we assay mitochondrial control region sequence...
Studies of the impact post‐marital residence patterns on distribution genetic variation within populations have returned conflicting results. These studies generally examined diversity and between groups with different post‐marriage patterns. Here, we directly examine Y chromosome microsatellite in individuals carrying a same haplogroup. We analyze data from two samples Yemeni males: sample representing entire country large highland village. Our results support normative patrilocality tribal...
Objectives Human brain development follows a unique pattern characterized by prolonged period of postnatal growth and reorganization, peak in glucose utilization. The molecular processes underlying these developmental changes are poorly characterized. objectives this study were to determine trajectories gene expression examine the evolutionary history genes differentially expressed as function age. Methods We used microarrays age‐related patterns mRNA human cerebral cortical samples ranging...
Whole-genome studies of genetic variation are now performed routinely and have accelerated the identification disease-associated allelic variants, positive selection, recombination, structural variation. However, these sensitive to presence outlier data from individuals different ancestry than rest sample. Currently, most common method excluding is collect a population sample exclude outliers after genome-wide been collected. Here we show that small collection 20–27 polymorphic Alu...
Abstract The methods of geometric morphometrics are commonly used to quantify morphology in a broad range biological sciences. application these large datasets is constrained by manual landmark placement limiting the number landmarks and introducing observer bias. To move field forward, we need automate morphological phenotyping ways that capture comprehensive representations variation with minimal Here, present Morphological Variation Quantifier (morphVQ), shape analysis pipeline for...