A5045873705- Advanced Neuroimaging Techniques and Applications
- Functional Brain Connectivity Studies
- Reproductive System and Pregnancy
- Advanced MRI Techniques and Applications
- Botulinum Toxin and Related Neurological Disorders
- Salivary Gland Tumors Diagnosis and Treatment
- Cerebral Palsy and Movement Disorders
- Oral and Maxillofacial Pathology
- Stress Responses and Cortisol
- Liver Disease Diagnosis and Treatment
- Nerve injury and regeneration
- Hypothalamic control of reproductive hormones
- Cytokine Signaling Pathways and Interactions
- Liver Disease and Transplantation
- Meningioma and schwannoma management
- Vascular anomalies and interventions
- Escherichia coli research studies
- Vagus Nerve Stimulation Research
- Anatomy and Medical Technology
- Liver physiology and pathology
- Iron Metabolism and Disorders
- Salivary Gland Disorders and Functions
- Cancer and Skin Lesions
- Neurogenesis and neuroplasticity mechanisms
- Transgenic Plants and Applications
University of Cagliari
2013-2024
Royal College of Surgeons in Ireland
2024
Istituto Nazionale di Fisica Nucleare, Sezione di Cagliari
2020-2024
Alzheimer’s disease (AD) is a complex neurodegenerative condition characterized by multifaceted interplay of genetic, environmental, and pathological factors. Traditional diagnostic research methods, including neuropsychological assessments, imaging, cerebrospinal fluid (CSF) biomarkers, have advanced our understanding but remain limited late-stage detection challenges in modeling progression. The emergence three-dimensional (3D) brain organoids (BOs) offers transformative platform for...
The human subthalamic area is a region of high anatomical complexity, tightly packed with tiny fiber bundles. Some them, including the pallidothalamic, cerebello-thalamic, and mammillothalamic tracts, are relevant targets in functional neurosurgery for various brain diseases. Diffusion-weighted imaging-based tractography has been suggested as useful tool to map white matter pathways vivo non-invasively, though reconstruction these specific bundles challenging due their small dimensions...
The present work was undertaken to investigate the effects of acute forced swimming (FS) on levels brain-derived neurotrophic factor (BDNF) and tyrosine kinase receptor B (trkB) proteins in: ventral tegmental area (VTA); nucleus accumbens (Acb) shell core compartments; anterior cingulate (ACg), prelimbic (PL) infralimbic (IL) territories prefrontal cortex genetic models vulnerability (RLA, Roman low-avoidance rats) resistance (RHA, high-avoidance stress-induced depression. We report for...
Abstract A general belief exists that tissue from anatomical donors, especially the central nervous system (CNS), may not be suitable for histological investigation. This is based on idea fixation routinely used in embalming whilst optimal enabling dissection, insufficiently preserves architecture at cellular level. However, donors represent a precious resource microscopical investigation, provided preservation sufficient to enable recognition of structures could considerably extend...
The immunomodulatory effects of HLA-G expression and its role in cancers, human liver infections transplantation are well documented, but so far, there only a few reports addressing autoimmune diseases, particularly hepatitis (AIH).We analyzed the genetic phenotypic characteristics 205 type 1 AIH patients (AIH-1) population 210 healthy controls from Sardinia (Italy).Analysis locus showed no substantial differences allele frequencies between control population. UTR-1 haplotype was most...
Sickle cell disease (SCD) is caused by the homozygous beta-globin gene mutation that can lead to ischemic multi-organ damage and consequently reduce life expectancy. On other hand, sickle trait (SCT), heterozygous mutation, still considered a benign condition. Although mechanisms are not well understood, clinical evidence has recently shown specific pathological symptoms also be recognized in SCT carriers. So far, there scant data regarding morphological modifications referable possible...
In this article, we describe the effects of tail pinch (TP), a mild acute stressor, on levels brain-derived neurotrophic factor (BDNF) and its tyrosine kinase receptor B (trkB) proteins in hippocampus (HC) outbred Roman High- (RHA) Low-Avoidance (RLA) rats, one most validated genetic models for study fear/anxiety- stress-related behaviors. Using Western blot (WB) immunohistochemistry assays, show first time that TP induces distinct changes BDNF trkB dorsal (dHC) ventral (vHC) HC RHA RLA...
What textbooks usually call the sublingual gland in humans is reality a tissue mass of two types salivary glands, anteriorly located consisting cluster minor glands and posteriorly major with its outlet via Bartholin's duct. Only recently, adrenergic cholinergic innervations was reported, while information regarding neuropeptidergic nitrergic still lacking.
The pulvinar, the largest nucleus in human thalamus, is a complex, highly interconnected structure. Through dense, organized network of cortical and subcortical areas, it provides adequate cooperation between neural systems, which crucial for multiple high-order functions such as perception, visuospatial attention, emotional processing. Such central role made possible by precise internal topographical organization, mirrored anatomical connections well expression neurochemical markers. While...
The pulvinar, the largest nucleus in human thalamus, is a complex, highly interconnected structure. Through dense, organized network of cortical and subcortical areas, it provides adequate cooperation between neural systems, which crucial for multiple high-order functions such as perception, visuospatial attention, emotional processing. Such central role made possible by precise internal topographical organization, mirrored anatomical connections well expression neurochemical markers. While...
The pulvinar, the largest nucleus in human thalamus, is a complex, highly interconnected structure. Through dense, organized network of cortical and subcortical areas, it provides adequate cooperation between neural systems, which crucial for multiple high-order functions such as perception, visuospatial attention, emotional processing. Such central role made possible by precise internal topographical organization, mirrored anatomical connections well expression neurochemical markers. While...
To contribute to the knowledge of autonomic innervation in liver regeneration, here we investigate distribution tyrosine hydroxylase (TH)- and choline acetyltransferase (ChAT)-like immunoreactive (LI) nerve fibers, indicate noradrenergic cholinergic nerves, respectively, rats under different conditions damage repair. By immunohistochemistry assessment fiber density, three models induced hepatic regeneration were examined: carbon tetrachloride (CCl4 ) intoxication, with two treatment periods...