A5009659441- Gallbladder and Bile Duct Disorders
- Pancreatic and Hepatic Oncology Research
- Pediatric Hepatobiliary Diseases and Treatments
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Neuroendocrine Tumor Research Advances
- Fungal Infections and Studies
- Organ Transplantation Techniques and Outcomes
- Breast Cancer Treatment Studies
- Parasite Biology and Host Interactions
- Congenital Anomalies and Fetal Surgery
- Monoclonal and Polyclonal Antibodies Research
- Esophageal and GI Pathology
- Pancreatitis Pathology and Treatment
- Antifungal resistance and susceptibility
- Neuroblastoma Research and Treatments
- HER2/EGFR in Cancer Research
- Nail Diseases and Treatments
- Traumatic Ocular and Foreign Body Injuries
- Maternal and Perinatal Health Interventions
- Parasitic infections in humans and animals
- Organ Donation and Transplantation
- Helminth infection and control
- Lung Cancer Research Studies
- Dental Research and COVID-19
- Liver Disease Diagnosis and Treatment
Tribhuvan University Teaching Hospital
1970-2024
Pokhara University
2024
Institut d'Etudes Politiques de Paris
2024
Tribhuvan University
2024
Dhulikhel Hospital
2016-2023
Kathmandu University
2016-2023
Creative Commons
2023
North Bengal Agricultural University
2022
Bedford Hospital NHS Trust
2020
Patan Academy of Health Sciences
2019
The high cost of trastuzumab (Herceptin®) limits its accessibility for patients worldwide. Biosimilars, such as Tuznue® (HD201), represent a promising alternative to improve access this essential therapy HER2-positive breast cancer. This study aims assess the similarity with reference product Herceptin® through comprehensive analytical and biofunctional evaluations, ensuring similar quality, safety, efficacy profiles. Multiple methods were performed key quality attributes Herceptin®....
Abstract Background Pancreatic Adenocarcinoma Up-regulated Factor (PAUF) protein is overexpressed in pancreatic adenocarcinoma and reported to contribute metastasis chemoresistance. PBP1510, a novel first-in-class humanized monoclonal antibody (mAb), anticipated demonstrate anti-tumor effects by neutralization of PAUF functions. PAUF-I (NCT05141149) an ongoing, open-label, multi-center clinical study evaluate PBP1510 advanced/metastatic patients. Here, we present preliminary safety results...
e16363 Background: Pancreatic Adenocarcinoma Up-regulated Factor (PAUF), a protein overexpressed in pancreatic adenocarcinoma, contributes to metastasis and chemoresistance. PBP1510 is first-in-class humanized anti-PAUF monoclonal antibody (mAb) with tumor-suppressing potential. PAUF-I (NCT05141149) an ongoing, open-label, multi-national clinical study evaluate advanced/metastatic adenocarcinoma patients. Safety results from the first two combination cohorts (PBP1510 gemcitabine) are...
The drug HD201 is a biosimilar candidate for breast cancer treatment as the reference trastuzumab.
Introduction: Appendectomy is one of the most commonly performed surgeries usually done by conventional open method. The role laparoscopic appendectomy still not well defined in literature and although widely practiced it hasn’t gained popularity Nepal. aim this study was to compare outcomes versus appendectomy.Methods: A prospective carried out, between August 2013 September 2014, involving 216 patients (93 males 123 females) with a diagnosis acute appendicitis based on Alvarado score seven...
Biliary stents are frequently associated with various complications; however biliary stent migration causing duodenal perforation is rare and has only been reported in few cases.We present a case of 33 years old male pain abdomen fever for 2 days came to Emergency department. He had undergone open common bile duct exploration (CBD), clearance stone placement CBD stent. In X-ray abdomen, was suspected. CECT done the confirmation diagnosis which showed migrated perforation. Patient underwent...
Objective: Overall objective of the study was to see effects active management third stage labour (AMSTL) with oxytocin. Specific look for incidence Post-Partum Haemorrhage (PPH), length 3rd stage, retained placenta and average blood loss. Methodology: A hospital based prospective, descriptive, observational carried out from 1st July 2005 30th June 2006 at department Obstetrics Gynaecology, Kathmandu Medical College Teaching Hospital (KMCTH). All patients undergoing vaginal delivery...
Introduction The prognostic significance of the controlling nutritional status (CONUT) score in hepatopancreatobiliary (HPB) surgery has been shown by many studies but clinical CONUT for postoperative short-term outcomes remains controversial. This study aimed to investigate impact on early patients following major HPB surgery. Method was a prospective 57 who underwent from November 2019 January 2021 at Department Surgical Gastroenterology, Tribhuvan University Teaching Hospital, Nepal....
<ns4:p>A 50 year old woman from Nepal had clinical features suggestive of meningitis. Cerebrospinal fluid (CSF) analysis was normal except for the presence cryptococcal antigen. The inclusion test <ns4:italic>Cryptococcus</ns4:italic> in CSF helped making diagnosis meningitis our patient who apparently immunocompetent. Treatment with liposomal amphotericin B could not be started on time due to financial constraints. a stroke and further deteriorated. Liposomal is stocked by government free...
Introduction: The purpose of this study was to establish reference ranges total thyroid volume among clinically euthyroid Nepalese population using Ultrasonography and correlate with age, sex, individual’s built geographic location. Methods: This a prospective cross sectional involving 485 individuals. B - mode used measure the by combining both lobes obtained formula for prolate ellipsoid. Age specific values were Pearson correlation test see relationship various factors. Results: Among...
Background and Objectives: The surgical treatment of liver hydatid disease has evolved dramatically laparoscopic shown encouraging results with the advantages minimally invasive surgery. We conducted this study to determine outcome management liver.Methods: Consecutive patients reporting our department from July 2014 2015 were offered management. All received pre- postoperative albendazole. technique consisted aspiration cyst fluid, sterilization, suction drainage cavity, deroofing addition...
Abstract Background The TROIKA trial established that HD201 and trastuzumab were equivalent in terms of primary endpoints (total pathological complete response) following neoadjuvant treatment. objective the present analysis was to compare survival outcomes final safety. Methods In trial, patients with ERBB2-positive early breast cancer randomized treated either or referent trastuzumab. Eligible received 8 cycles (loading dose, mg/kg; maintenance 6 mg/kg) every 3 weeks combination...
Penetrating chest injuries are mainly caused by gunshot trauma and stab injuries. These lead to damage the vital structures, which requires a multidisciplinary approach for management.We present case of an accidental injury (GSI) resulting in left-sided hemopneumothorax, left lung contusion, D11 burst fracture with spinal cord injury. The patient underwent thoracotomy remove bullet along instrumentation fixation fracture.Penetrating prompt resuscitation stabilization eventual definitive...
Castleman's disease (CD) of the pancreas is a rare benign which can sometime resemble pancreatic neuroendocrine tumor.We report case 46-years-old lady with an incidental lesion. Preoperative diagnosis was tumor pancreas, for anterior Radical Antegrade Modular Pancreatosplenectomy surgery (RAMPs) performed. The postoperative histopathology showed features consistent hyaline vascular type disease. She had uneventful surgical procedure and no serious complications.Pancreatic usually difficult...
Objectives: To evaluate the knowledge and attitude of Nepalese women towards mode delivery caesarean on demand. Study design: Hospital based cross sectional descriptive study where 200 pregnant after 37 completed weeks gestation were recruited randomly interviewed, their answers analyzed. Results: Of interviewed women, all them knew about normal vaginal delivery, but only 30% instrumentally assisted 9% had heard painless labour. Vaginal was preferred in 93% 7% delivery. Only 35% believed...
Mixed serous-neuroendocrine neoplasm constitutes pancreatic serous cystic neoplasms and neuroendocrine tumor, two tumor components with different underlying pathologies. The differentiation of these tumors is important as the management prognosis depend on component. We report a case mixed in 47-year-old female who presented epigastric pain abdomen for years. Imaging studies, markers, thorough systemic evaluation, surgical resection, histopathological examination, timely follow-up...
Aims: The purpose of this study was to the feasibility inclusion 3-vessel view (3-VV) fetal upper mediastinum in routine anomaly screening; and size relationship these vessels namely, main pulmonary artery (MPA), ascending aorta (AA) superior venacava (SVC) fetuses between 17 24 weeks pregnancy by antenatal ultrasound. Methods: This a prospective cross sectional involving 106 pregnant ladies gestation. time burden examination due addition 3-VV screening recorded. relationships three great...
Aims: The purpose of this study was to evaluate accuracy trans-cerebellar diameter / abdominal circumference (TCD/AC) ratio assess fetal growth. TCD with head (HC) and biparietal (BPD) also determined. Methods: This a prospective cross-sectional involving 442 women uncomplicated singleton gestation between 15-40 weeks. Protocol included obtaining the BPD, HC, AC in conventional planes other biometric parameters.Results: We were able visualize cerebellum about 93% scans. TCD/ remained nearly...
Lupus enteritis is uncommon in patients with SLE and usually presents anorexia, vomiting, abdominal pain. Intestinal perforation as an initial manifestation of rare can have a grave prognosis if not timely diagnosed.We report unusual case 22-year-old regularly menstruating female who presented features peritonitis lupus enteritis. Intraoperatively, gangrenous ileal segment multiple perforations was present. Thus, intraoperative diagnosis peritonitis, the small bowel resected double-barrel...
Paraduodenal hernia is a rare cause of internal hernia. It the herniation small bowel through peritoneal sac in duodenum. occurs due to incomplete rotation and fixation abnormalities primitive midgut during fetal development. We report case right sided paraduodenal an adult male.This 36-year-old gentleman who presented with complaints abdominal fullness upper pain for 1.5 months 7 8 episodes vomiting. CT scan abdomen gave impression right-sided Exploratory laparotomy repair was performed...
Chyle leak is the leakage of milk-like triglyceride-rich lymphatic fluid from system to peritoneal cavity. The incidence chyle after radical gastrectomy very low.
Abstract Background Pancreatic Adenocarcinoma Up-regulated Factor (PAUF) is a protein overexpressed in pancreatic cancer but not non-cancerous tissues and plays an important role carcinogenesis metastasis. PBP1510 first-in-class, anti-PAUF humanized immunoglobulin G1 monoclonal antibody developed for treatment of cancer. demonstrated promising growth inhibition efficacies vivo patient-derived xenograft studies being evaluated humans the first time ongoing PAUF-I study. Methods (NCT05141149)...