A5047681672- Digital Holography and Microscopy
- Fuzzy Logic and Control Systems
- Interconnection Networks and Systems
- Photonic and Optical Devices
- Integrated Circuits and Semiconductor Failure Analysis
- Image Processing Techniques and Applications
- Image and Signal Denoising Methods
- VLSI and FPGA Design Techniques
- Advanced Optical Imaging Technologies
- Optical measurement and interference techniques
- Embedded Systems Design Techniques
- Advanced Image Processing Techniques
- Random lasers and scattering media
- Advanced X-ray Imaging Techniques
- Advanced Algebra and Logic
- Genomics and Chromatin Dynamics
- Advanced Image Fusion Techniques
- Acute Myeloid Leukemia Research
- Advanced Fluorescence Microscopy Techniques
- Near-Field Optical Microscopy
- Cancer Genomics and Diagnostics
- Advanced Surface Polishing Techniques
- Blood disorders and treatments
- Advanced Optical Sensing Technologies
- Advanced Electron Microscopy Techniques and Applications
MRC Weatherall Institute of Molecular Medicine
2022-2025
University of Oxford
2022-2025
Medical Research Council
2023-2024
Azrieli College of Engineering Jerusalem
2012-2023
Izmir Institute of Technology
2022
Kadir Has University
2022
Shenkar College of Engineering and Design
2006-2017
Jerusalem College of Technology
2012
Tel Aviv University
1998-2009
Bar-Ilan University
2009
Abstract The chromatin remodeller ATRX interacts with the histone chaperone DAXX to deposit variant H3.3 at sites of nucleosome turnover. is known bind repetitive, heterochromatic regions genome including telomeres, ribosomal DNA and pericentric repeats, many which are putative G-quadruplex forming sequences (PQS). At these plays an ancillary role in a wide range nuclear processes facilitating replication, modification transcription. Here, using improved protocol for immunoprecipitation, we...
Diagnosis of malaria must be rapid, accurate, simple to use, portable and low cost, as suggested by the World Health Organization (WHO). Despite recent efforts, gold standard remains light microscopy a stained blood film. This method can detect parasitemia identify different species Plasmodium. However, it is time consuming, requires well trained microscopist good instrumentation minimize misinterpretation, thus costs are considerable. Moreover, equipment cannot easily transported installed....
Abstract Bulk ATAC-seq assays have been used to map and profile the chromatin accessibility of regulatory elements such as enhancers, promoters, insulators. This has provided great insight into regulation gene expression in many cell types a variety organisms. To date, most often provide an average evaluation populations cells. The development single approach (scATAC-seq) assay enables researchers evaluate individual cells identify sub-groups mixed investigate full potential single-cell...
Genome regulatory elements are fundamental to cellular identity and cell type specific gene expression. Understanding how the underlying genetic code is differentially utilised by different types central understanding human health disease. To better understand DNA encodes genome such as promoters, enhancers, boundary elements, we leverage Enformer expression epigenetic prediction model. We used transfer learning with high quality single ATAC datasets develop REnformer, a model predict...
The task of segmenting cell nuclei in microscope images is a classical image analysis problem. accurate segmentation may contribute to development successful system which automate the for pathology detection. In this article we describe method semi-supervised training fuzzy logic engine. engine applied connect set parameters proven be important nucleus segmentation. addition each parameter itself detected using rules. We present results
We present a new configuration for superresolution (SR) as well field-of-view (FOV) extension in digital holography concept based on random movement of sparse metallic particles. In the SR configuration, particles are proximity to recorded object, while FOV hologram plane. The particles' encodes high spatial features plane their movement. This high-resolution information can later be decoded by proper numerical postprocessing that either remedies resolution limitations object (or limited NA...
Abstract Fundamental challenge of imaging through a scattering media has been resolved by various approaches in the past two decades. Optical wavefront shaping technique is one such method which shapes light entering using shaper that it cancels effect. It most effective focusing inside media. Unfortunately, these techniques require direct access to medium or need know properties beforehand. Through novel scheme presented on this paper, both illumination module and detection are same side...
Abstract With the boom in Genome-Wide Association Studies (GWAS), it has become apparent that many disease-associated genetic variants lie non-coding regions of genome. In order to prioritise these and disentangle their functional significance, is important be able accurately classify cis-regulatory elements within Historically, classification relied purely on presence characteristic histone marks, with recent advancements using more sophisticated Hidden Markov Model (HMM)-based approaches....
Text recognition and retrieval is a well known problem. Automated optical character (OCR) tools do not supply complete solution in most cases human inspection required. In this paper the authors suggest novel text algorithm based on usage of fuzzy logic rules relying statistical data analyzed font. The new approach combines letter statistics correlation coefficients set rules, enabling distorted letters that may be retrieved otherwise. focused Rashi fonts associated with commentaries Bible...
In this Letter the authors present a field experimental validation of an imaging system that, when combined with special image-processing algorithm, allows obtaining improved quality through turbulence perturbation. The includes simultaneous capturing three differently focused images and performing iterative Gerchberg-Saxton based processing for phase retrieval. After is retrieved intensity object reconstructed by numerical free-space propagation extracted complex to estimated position object.
Assay for transposase-accessible chromatin (ATAC) and immunoprecipitation (ChIP), coupled with next-generation sequencing (NGS), have revolutionized the study of gene regulation. A lack standardization in analysis highly dimensional datasets generated by these techniques has made reproducibility difficult to achieve, leading discrepancies published, processed data. Part this problem is due diverse range bioinformatic tools available types Secondly, a number different are required...
In recent years fuzzy-logic-based controllers have become the preferred tool for implementing control mechanisms in high-complexity systems. We suggest novel implementations of a basic fuzzy controller. First, we show principles fuzzy-logic and explain concept behind optical Next review one-dimensional optoelectronic controller that was suggested 1994. Finally, present two-dimensional approach accompanied by computer simulations an inverted pendulum. The setup is first given dual-input then...
In this paper, we present a new numerical approach for enhancing the resolving power of low-resolution (LR) images, which can be applied failure analysis microelectronic chips. The resolution improvement is based upon iterative comparison between Radon transform high-resolution layout image and an LR experimentally captured same region interest.
In the last third of 20th century, fuzzy logic has risen from a mathematical concept to an applicable approach in soft computing. Today, is used control systems for various applications, such as washing machines, train-brake systems, automobile automatic gear, and so forth. The optical implementation inferencing was given by authors previous papers, giving extra emphasis applications with two dominant inputs. this paper introduce real-time rule generator dual-input fuzzy-inference engine....
In this paper, we present a new numerical approach for improving the resolving power of low-resolution (LR) images. This may be applied failure analysis microelectronic chips. The resolution improvement is based upon iterative comparison between LR experimentally captured image and high-resolution layout same region interest.
One of the most fascinating problems addressed today is retrieving high-resolution data blurred images obtained from biological objects. In cases research relays either on a priory knowledge image nature or large number (either same object different objects by imaging setup). If saturation added to blurring, algorithms fail sharpen and in some researchers decline use such as an input. this work single captured saturated given with no priori except fact that primary blurring due defocused...
Super-resolution and image enhancement are frequently sought for in remote sensing. Many approaches were used over the years to obtain this yearned enhancement. In article, authors present a novel super-resolution approach based on iterative data fusion algorithms. The proposed algorithm can be implemented using either plurality of images with varied resolution generated from different regions field view, or spectral same region. suggested is gradual, allowing build-up one single...
Fuzzy-logic inference engines are in use various disciplines such as control systems, medicine, and the like. The of optical tools to implement may improve performance flexibility procedures. processor works a two-dimensional environment, whereas engine might have handle more than two independent input channels. Here several approaches generating first, our knowledge, N-dimensional fuzzy addressed. first approach uses space multiplexing, second polarization third wavelength multiplexing...
The allocation of CPU time and memory resources, are well known problems in organizations with a large number users, single mainframe. Usually, the amount resources given to user is based on its own statistics, not entire statistics organization therefore patterns identified system prodigal. In this work authors suggest fuzzy logic-based algorithm optimize distribution between users history users. works separately heavy light since they have different be observed. result set rules, generated...