A5102980699- Advanced MRI Techniques and Applications
- Advanced Neuroimaging Techniques and Applications
- Functional Brain Connectivity Studies
- Brain Tumor Detection and Classification
- Ubiquitin and proteasome pathways
- RNA modifications and cancer
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Cardiac pacing and defibrillation studies
- Cardiovascular Disease and Adiposity
- Cardiac Structural Anomalies and Repair
- Pulmonary Hypertension Research and Treatments
- Vascular Anomalies and Treatments
- Cardiac Arrhythmias and Treatments
- Heart Rate Variability and Autonomic Control
- Pleural and Pulmonary Diseases
- Respiratory Support and Mechanisms
- Genomics and Chromatin Dynamics
The Ohio State University Wexner Medical Center
2021-2023
University of Iowa
2006
The development and progression of cancer is controlled by gene expression, often regulated through chromatin packaging. Heterochromatin protein 1(Hsalpha) (HP1(Hsalpha)), one three human HP1 family members, participates in heterochromatin formation regulation. HP1(Hsalpha) possesses an amino-terminal chromodomain, which binds methylated lysine 9 histone H3 (meK9 H3), a carboxyl-terminal chromoshadow domain (CSD) that required for dimerization interaction with partner proteins....
ABSTRACT Patients with coronary artery disease (CAD) face an increased risk of cognitive impairment, dementia, and stroke. While white matter (WM) lesions are frequently reported in patients CAD, the effects on WM microstructure alterations remain largely unknown. We aimed to identify microstructural individuals CAD compared healthy controls (HC), examine their relationships performance. Forty-three (43) 36 HC aged 50 older underwent comprehensive neuropsychological testing multi-modal 3T...
Here we investigated the effect of coronary artery disease (CAD) on brain oxygen extraction fraction (OEF) using quantitative susceptibility mapping (QSM). Our results, in a pilot dataset, show that OEF was significantly higher CAD patients than healthy controls caudate nucleus. This may be result declining cerebrovascular health this region. However, since nucleus is iron-rich, difference also interpreted as iron deposition has known neuroinflammatory effect. Future work will investigate...
Here we characterized the impact of coronary artery disease (CAD) on brain’s white matter (WM) using diffusion tensor (DTI) and neurite orientation dispersion density imaging (NODDI). Mean diffusivity was higher in CAD patients occipital WM there were differences several tracts between healthy controls. Alterations fiber cerebellar associated with global cognition, episodic memory, processing speed. Our study supports use advanced models for early detection subtle damage populations at risk...
Motivation: There is a lack of knowledge about the physiological underpinnings effects coronary artery disease (CAD) on human brain health. Goal(s): Here we investigated effect CAD oxygen extraction fraction (OEF) Approach: Using quantitative susceptibility mapping (QSM) and its relation to cognitive performance cardiorespiratory fitness. Results: The results sex-disaggregated analysis in preliminary dataset show that male patients have significantly higher OEF whole gray matter, frontal,...
Pulmonary arterial dissection (PAD) is a rare and often lethal complication of chronic pulmonary hypertension (PAH), which may occurs in patients with idiopathic (IPAH) potentially those connective tissue disorders. While rare, sudden death secondary to acute cardiac tamponade, as the artery dissects into pericardium; this diagnosis made postmortem. Nevertheless, proliferation multidetector computed tomography (MDCT) diagnostic test, be identified very early after symptom onset, prompting...