Cevher Altuğ

ORCID: 0000-0003-4740-1138
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About
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Research Areas
  • Synthesis and biological activity
  • Synthesis and Biological Evaluation
  • Multicomponent Synthesis of Heterocycles
  • Synthesis and Catalytic Reactions
  • Synthesis and Characterization of Heterocyclic Compounds
  • X-ray Diffraction in Crystallography
  • Crystallization and Solubility Studies
  • Synthesis and Reactions of Organic Compounds
  • Phenothiazines and Benzothiazines Synthesis and Activities
  • Synthesis of heterocyclic compounds
  • Organic Chemistry Cycloaddition Reactions
  • Bioactive Compounds and Antitumor Agents
  • Plant Reproductive Biology
  • Plant Molecular Biology Research
  • Sulfur-Based Synthesis Techniques
  • Synthesis and Characterization of Pyrroles
  • Enzyme function and inhibition
  • Structural and Chemical Analysis of Organic and Inorganic Compounds
  • Plant tissue culture and regeneration
  • Olfactory and Sensory Function Studies
  • ZnO doping and properties
  • Chemical Reaction Mechanisms
  • Biochemical Analysis and Sensing Techniques
  • Photochromic and Fluorescence Chemistry
  • Cholinesterase and Neurodegenerative Diseases

Bolu Abant İzzet Baysal University
2011-2024

Cardiff University
2009-2011

Clausthal University of Technology
2008

University of Turku
2007

Abstract In this research, a wide range of aldoxime derivatives with aromatic and aliphatic substituents were synthesized as precursors to nitrile oxide in cycloaddition reactions. The aldoximes good high yields showed lack diastereoselectivity, confirmed by 1 H NMR measurements. These then utilized 1,3‐dipolar reactions treated dipolarophilic reagents, namely methyl methacrylate (MMA) glycidyl (GMA), produce isoxazoline carboxylate regioselectivity. obtained compounds characterized using...

10.1002/ffj.3778 article EN cc-by Flavour and Fragrance Journal 2024-02-29

Abstract This study focuses on the development of environmentally friendly and efficient synthetic routes for novel thiazolo[3,2‐ a ]pyridine‐6‐sulfonamide derivatives with potential antimicrobial properties. Using one‐pot multi‐component approach, these heterocyclic compounds were synthesized both in solution under solvent‐free mechanochemical conditions. Reactions between 1‐(4‐oxothiazolidin‐2‐ylidene)‐ N ‐phenylmethane sulfonamide, malononitrile, aryl aldehydes led to two distinct classes...

10.1002/slct.202500410 article EN ChemistrySelect 2025-04-01

Alkylidenepyrrolidines 1, 21, 24 and 26 undergo reactions with nitrile oxides nitrilimines or their precursors to give a range of novel heterocyclic compounds. With alkylidenepyrrolidine ester nitrolic acids products in which the liberated nitrous acid reacts alkylidenepyrrolidine, followed by two cycloadditions adducts 3. In contrast, hydroximoyl chlorides isoxazoles 10, presumably cycloaddition/elimination. hydrazonyl chlorides, simple acylation occurs compounds 17. sulfonyl...

10.1039/c0ob00286k article EN Organic & Biomolecular Chemistry 2010-01-01

A Pt-modified titania-based catalyst was successfully applied in the synthesis of amines employing several carbonyl containing molecules and nitriles.

10.1039/c8gc03037e article EN Green Chemistry 2018-11-29

A series of ten novel pyridine N-oxide-bearing 5-aminoisoxazoles was efficiently synthesized in moderate yield by reacting 2-(cyanomethyl)pyridine 1-oxide with α-chlorooximes, employing sodium ethoxide as a base. The compounds were verified variety spectra. Subsequently, the inhibitory potency 4c, 4e, 4f, 4h, and 4i against AChE BChE, primary targets Alzheimer's disease, assessed. In silico docking analyses conducted to evaluate interaction MAO-B. Among tested compounds, 4e 4h demonstrated...

10.1016/j.molstruc.2024.138667 article EN cc-by Journal of Molecular Structure 2024-05-17

Twenty one new thiophene-substituted 1,2,4-oxadiazol-5(4H)-ones, 1,2,4-oxadiazol-5(4H)-thiones, and 1,2,4-oxadiazin-5(6H)-ones were synthesized by the reaction of thiophene-ring substituted amidoximes with ethyl chloroformate, thiophosgene, chloroacetylchloride, respectively. Their structure elucidation was performed means spectral measurements (IR, NMR, MS) physical data.

10.1080/10426500600919124 article EN Phosphorus, sulfur, and silicon and the related elements 2007-01-01

The recently reported capability of pentachloro-2-nitro­butadiene and some closely related derivatives to allow the synthesis highly substituted acyclic as well five-membered (hetero)cyclic compounds is herein extended pyrimidines with an exceptional substitution pattern. Our novel approach starts from a 1,1-diamino-3,4,4-trichloro-2-nitrobuta-1,3-diene appropriate amidine. Some resulting perfunctionalized were subjected further transformations give promising candidates respect biological,...

10.1055/s-2007-990948 article EN Synthesis 2008-01-01

A series of thiazolo[3,2-a]pyridin-8-yl-phosphonate derivatives have been obtained by the reaction diethyl (E)-((4-oxothiazolidin-2-ylidene)methyl)phospohonate, malononitrile and two equivalent various aromatic aldehydes in a multicomponent with good yields. The structures new compounds are confirmed spectroscopic methods (IR, 1H, 13C, 31P NMR HRMS). Compound diethyl-(Z)-(5-amino-6-cyano-2-(4-nitrobenzylidene)-7-(4-nitrophenyl)-3-oxo-3,7-dihydro-2H-thiazolo[3,2-a]pyridin -8-yl)phosphonate...

10.1080/10426507.2018.1513515 article EN Phosphorus, sulfur, and silicon and the related elements 2018-12-10
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