A5046133817- Diet and metabolism studies
- Nutritional Studies and Diet
- Fatty Acid Research and Health
- Health Systems, Economic Evaluations, Quality of Life
- Geriatric Care and Nursing Homes
- Physical Activity and Health
- Prostate Cancer Treatment and Research
- Obesity, Physical Activity, Diet
- Health disparities and outcomes
- Homelessness and Social Issues
- COVID-19 and Mental Health
- Health, psychology, and well-being
- Hip and Femur Fractures
- Organ Donation and Transplantation
- Urban Green Space and Health
- Food Security and Health in Diverse Populations
- Hormonal and reproductive studies
- Migration, Health and Trauma
- Chronic Disease Management Strategies
- Blood donation and transfusion practices
- Mental Health and Patient Involvement
- Stroke Rehabilitation and Recovery
- Clinical practice guidelines implementation
- Frailty in Older Adults
- Intensive Care Unit Cognitive Disorders
University of East Anglia
2016-2025
Beth Israel Deaconess Medical Center
2024-2025
University of Botswana
2025
Botswana Harvard AIDS Institute Partnership
2024-2025
University of Bath
2024
Norwich Research Park
2021-2024
Pfizer (United States)
2023-2024
Royal National Hospital for Rheumatic Diseases
2024
Royal United Hospital Bath NHS Trust
2024
Lockheed Martin (United States)
2022
To provide baseline cohort descriptives and assess change in health behaviours since the UK COVID-19 lockdown.A prospective (N = 1,044) of people recruited online, purposively targeting vulnerable populations.After a survey (April 2020), participants completed 3 months daily ecological momentary assessments (EMA). Dietary, physical activity, alcohol, smoking, vaping substance use collected retrospectively for pre-COVID-19 period were compared with EMA surveys over first 30 days during early...
Recent evidence indicates that transcriptional abnormalities may play an important role in the pathophysiology of polyglutamine diseases. In present study, we have explored extent to which polyglutamine-related changes gene expression be independent protein context by comparing mouse models dentatorubral–pallidoluysian atrophy (DRPLA) and Huntington's disease (HD). Microarray profiling was conducted mice same background strain promoter employed direct full-length atrophin-1 or partial...
There is limited evidence on the optimal strategy for liberating infants and children from invasive mechanical ventilation in pediatric intensive care unit.To determine if a sedation ventilator liberation protocol intervention reduces duration of anticipated to require prolonged ventilation.A pragmatic multicenter, stepped-wedge, cluster randomized clinical trial was conducted that included 17 hospital sites (18 units) UK sequentially usual intervention. From February 2018 October 2019, 8843...
Both transcriptional dysregulation and proteolysis of mutant huntingtin (htt) are postulated to be important components Huntington's disease (HD) pathogenesis. In previous studies, we demonstrated that transgenic mice express short htt fragments containing 171 or fewer N-terminal residues (R6/2 N171-82Q mice) recapitulate many the mRNA changes observed in human HD brain. To examine whether protein length influences ability its expanded polyglutamine domain alter gene expression, conducted...
Increasingly, both mothers and fathers are expected to play an equal role in child rearing. Nonetheless, we know little about how care arrangements affect couples’ sexual intimacy relationship quality. Research has focused on the effect of division paid labor housework relationships, finding that egalitarianism is problematic for intimacy, quality, stability. These findings, however, come almost universally from studies utilizing decades-old data fail examine care. In this study, update work...
Combination androgen deprivation therapy (ADT) with radiotherapy is commonly used for patients localized and advanced prostate cancer.
BACKGROUND: Novice blood donors are at increased risk for unpleasant donation‐related symptoms (e.g., dizziness, weakness, and lightheadedness), the experience of such can contribute to a decreased likelihood repeat donation. Recent laboratory studies suggest that water ingestion produces hemodynamic effects may be sufficient reduce syncope related reactions during STUDY DESIGN AND METHODS: Male female volunteers were randomly assigned ingest either 500 or 0 mL 30 minutes before donating...
Abstract Although contemporary couples increasingly express preferences for egalitarian unions, previous research has suggested that sexual intimacy decreases when routine housework is shared. Yet this was conducted on data are decades old. To update work, the authors compared from 2006 Marital and Relationship Survey (MARS) Wave 2 of National Families Households (NSFH2), collected in 1992–1994. The results indicated change association between arrangements across surveys. were associated...
BACKGROUND: The experience of unpleasant blood donation reactions (e.g., dizziness, nausea, and fainting) has been linked to negative attitudes about decreased likelihood repeat donation. Consequently, interventions reduce the adverse effects are important likely increase donor retention. Based on laboratory studies suggesting that social support attenuates both physical psychological responses stress, present study hypothesized presence a supportive person during process may help reactions....
In the HERO study, relugolix demonstrated sustained testosterone suppression superior to that of leuprolide acetate (97% vs 89%; difference 7.9% [95% confidence interval, 4.1-12%; p < 0.001]).
Extreme rituals (body-piercing, fire-walking, etc.) are anecdotally associated with altered states of consciousness—subjective alterations ordinary mental functioning (Ward, 1984)—but empirical evidence using both direct and indirect measures during extreme in naturalistic settings is limited. Participants the "Dance Souls", a 3.5-hour event which participants received temporary piercings hooks or weights attached to danced music provided by drummers, responded two consciousness. also...
Walking groups have known health benefits but may not operate in communities with the greatest needs, leading to potential for increasing inequity. This study examined process of implementing a new volunteer led walking group scheme deprived community England poor physical activity, and socio-economic indicators. Documentary evidence semi-structured interviews stakeholders walk leaders undertaken at beginning end funding period were analysed thematically. It was found that utilising...
Walking groups can benefit health but uptake is more likely amongst those who are socially well-situated and need them least. This study worked with a new walking group in community England poor socio-economic indicators to understand non-participation barriers involvement. It used qualitative approach. Participant generated photographs captured the physical social environments which they walked these were semi-structured interviews inductively explore participation wider context of walking....
Objectives To assess the feasibility of conducting a pragmatic, multicentre randomised controlled trial (RCT) to test clinical and cost-effectiveness pain management training intervention support people with persistent musculoskeletal their informal carers. Design Two-arm, multicentre, open, RCT embedded qualitative study. Setting National Health Service (NHS) providers in four English hospitals. Participants Adults receiving NHS care for Intervention Control: usual care. Experimental: plus...