A5013499545- Synthesis and biological activity
- Synthesis and Characterization of Heterocyclic Compounds
- Multicomponent Synthesis of Heterocycles
- Synthesis and Biological Evaluation
- Synthesis and Reactions of Organic Compounds
- Click Chemistry and Applications
- Quinazolinone synthesis and applications
- Bioactive Compounds and Antitumor Agents
- X-ray Diffraction in Crystallography
- Phenothiazines and Benzothiazines Synthesis and Activities
- Synthesis and Reactivity of Sulfur-Containing Compounds
- Chemistry and Chemical Engineering
- HIV/AIDS drug development and treatment
- Microwave-Assisted Synthesis and Applications
- Crystallization and Solubility Studies
- Metal complexes synthesis and properties
- Synthesis of heterocyclic compounds
- Computational Drug Discovery Methods
- Carbohydrate Chemistry and Synthesis
- Chemical Synthesis and Reactions
- Organic Chemistry Cycloaddition Reactions
- Synthesis and Catalytic Reactions
- Nanoparticle-Based Drug Delivery
- Essential Oils and Antimicrobial Activity
- Synthesis and Reactivity of Heterocycles
Rashtrasant Tukadoji Maharaj Nagpur University
2014-2025
Indian Institute of Science Bangalore
2024
Govt. Dental College & Hospital
2020
Islamic University of Science and Technology
2016
KLE University
2003-2011
National Botanical Research Institute
2003
Government Medical College
2003
Kasturba Medical College, Manipal
1994
Antimicrobial and anticancer drugs are widely used due to increasing widespread infectious diseases caused by microorganisms such as bacterial, fungal, viral agents, or cancer cells, which one of the major causes mortality globally. Nevertheless, several developed resistance antibiotics a result genetic changes that have occurred over an extended period. Carbon-based materials, particularly carbon dots (C-dots), potential candidates for antibacterial nanomaterials their low toxicity, ease...
Abstract This review article aims to significantly advance the scientific community's efforts develop effective nucleoside‐based drugs for treating severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2 ) and other emerging infectious diseases. study concentrates on main viral protease (Mpro) explores compounds as potential therapeutic agents. investigation investigated impact of acylation‐induced modifications nucleoside hydroxyl group subsequent properties. Nucleoside analogs, which...
In this work, Schiff bases and Thiazolidin-4-ones, were synthesized using Sonication Microwave techniques, respectively. The base derivatives (3a–b) via the reaction of Sulfathiazole (1) with benzaldehyde (2a–b), followed by synthesis 4-thiazoledinone (4a–b) cyclizing through thioglycholic acid. All compounds characterized spectroscopic techniques such as FT IR, NMR HRMS. tested for their in vitro antimicrobial antioxidant vivo cytotoxicity hemolysis ability. displayed better activity low...
In this study, a series of thiazolidine-2,4-dione derivatives
In the present work, a series of novel pyridine carboxamides 3(a-h) were synthesized and screened with antibacterial activity. This research explores application Density Functional Theory (DFT) in studying biological systems at quantum mechanical level, particularly context drug design. DFT offers streamlined approach to calculations, making it indispensable various scientific fields, for its exceptional accuracy, reduced computational time, cost-effectiveness has become pivotal tool...
Carbohydrates, among the most abundant and widespread biomolecules in nature, play indispensable roles diverse biological functions represent a treasure trove of untapped potential for pharmaceutical applications. From this perspective, present study was designed to explore evaluate synthesis spectral characterization methyl α-D-glucopyranoside derivatives 2-6 with different aliphatic groups through comprehensive vitro antimicrobial screening, physicochemical analysis, molecular docking...
Carbohydrate analogs are an important, well-established class of clinically useful medicinal agents that exhibit potent antimicrobial activity. Thus, we explored the various therapeutic potential methyl α-D-mannopyranoside (MαDM) analogs, including their ability to synthesize and assess antibacterial, antifungal, anticancer properties; additionally, molecular docking, dynamics simulation, ADMET analysis were performed. The structure synthesized MαDM was ascertained by spectroscopic...
To discover anti-acetylcholinesterase agents for the treatment of Alzheimer's disease (AD), a series novel Schiff base-coumarin hybrids was rationally designed, synthesized successfully, and structurally characterized using Fourier transform infrared (FTIR), Nuclear magnetic resonance (NMR), High-Resolution Mass Spectrometry (HRMS) analyses. These were evaluated their potential inhibitory effect on acetylcholinesterase (AChE). All them exhibited excellent activity against AChE. The IC50...
An efficiently simple protocol for the synthesis of methyl 7 amino-4-oxo-5-phenyl-2-thioxo-2, 3, 4,5-tetrahydro-1H-pyrano[2,3-d]pyrimidine-6-carboxylates via one-pot three component condensation pathway is established microwave irradiation using varied benzaldehyde derivatives, methylcyanoacetate and thio-barbituric acid in water as a green solvent. A variety functionalized substrates were found to react under this methodology due its easy operability offers several advantages like, high...
Annulated pyrano[2,3-d]pyrimidine derivatives were synthesized via one-pot, three-component condensation reactions of various aromatic aldehydes, malononitrile and barbituric acid in aqueous ethanol using dibutylamine (DBA) as catalyst. The potential application DBA organic synthesis is increasing rapidly due to its reaction simplicity, minimal time, high yields the desired products (83–94%) low cost chemicals. All characterized by IR, 1H NMR, 13C NMR mass spectra.
Nucleoside derivatives are important therapeutic drugs that have drawn significant attention recently. In this study, cytidine (1) was first exposed to react with cinnamoyl chloride in N,N-dimethylformamide, and trimethylamine obtain 5′-O-(cinnamoyl)cytidine, which further treated several acylating agents a series of 2′,3′-di-O-acyl derivatives. The chemical structures the synthesized compounds were established through spectral, analytical, physicochemical techniques. vitro antimicrobial...
A selective method for the synthesis of annulated pyrano[2,3-d]pyrimidines has been developed. It was shown that base catalysis is more efficient in this reaction, rather than acid as it believed 1,4-diazabicyclo[2.2.2]octane (DABCO) N-type catalyst used pyrano[2,3-d]pyramidine derivatives via one-pot three component condensation reactions various aromatic aldehydes, active methylene compounds and barbituric aqueous ethanol carried at normal temperature. The potential application DABCO...
Marine compounds constitute a diverse and invaluable resource for the discovery of bioactive substances with promising applications in pharmaceutical development anti-inflammatory antibacterial agents. In this study, comprehensive methodology was employed, encompassing pharmacophore modeling, virtual screening, silico ADMET assessment (encompassing aspects absorption, distribution, metabolism, excretion, toxicity), molecular dynamics simulations. These methods were applied to identify new...
Abstract Three α ‐aminophosphonates derived from 2‐hydroxybenzaldehyde were synthesized and evaluated their biological activities. The antimicrobial antibiofilm properties of compounds 1A, 1B, 1C against a range pathogenic bacteria fungi, including four Gram‐negative bacteria: Escherichia coli, Klebsiella pneumoniae, Pseudomonas aeruginosa, Serratia marcescens ; one Gram‐positive bacterium: Staphylococcus aureus five yeasts the Candida genus: albicans, kefyr, krusei, lusitaniae , tropicalis...
In this work, a library of diverse chemically and medicinally important heterocyclic polyhydroquinoline derivatives was efficiently prepared via one-pot multicomponent reaction starting from various raw materials including aromatic aldehydes, dimedone or 1,3-cyclohexandione, ethyl acetoacetate methyl ammonium acetate in the presence Fe3O4/SiO2-OSO3H as sulfonated silica-based magnetic nanocatalyst high yields. Main advantages present practical approach are ready availability materials,...