A5003101520- Pain Management and Placebo Effect
- Empathy and Medical Education
- Pediatric Pain Management Techniques
- Complementary and Alternative Medicine Studies
- Paranormal Experiences and Beliefs
- Psychological Treatments and Assessments
- Ion channel regulation and function
- Metabolomics and Mass Spectrometry Studies
- Diet and metabolism studies
- Mindfulness and Compassion Interventions
- Pain Management and Opioid Use
- Menstrual Health and Disorders
- Psychosomatic Disorders and Their Treatments
- Health and Medical Studies
- Plant-based Medicinal Research
- Death Anxiety and Social Exclusion
University of Basel
2020-2025
University Hospital of Basel
2025
Objective To investigate the efficacy and safety of open-label placebos (OLP) in premenstrual syndrome (PMS). Design Randomised controlled trial. Setting Switzerland, 2018–2020. Participants 150 women (18–45 years age) with PMS or dysphoric disorder. Intervention Random assignment (1:1:1) to treatment as usual (TAU), OLP without rationale (OLP–), (OLP+). consisted two placebo pills per day for 6 weeks. Main outcome measures Primary outcomes were symptom intensity interference between groups...
Abstract Three meta-analyses have demonstrated the clinical potential of open-label placebos (OLPs). However, there is a need to synthesize existing evidence through more complex analyses that would make it possible answer questions beyond mere efficacy. Such serve improve understanding why and under what circumstances OLPs work (e.g., depending on induced expectations or across different control groups). To these questions, we conducted first network in field OLPs. Our revealed could be...
Abstract Placebos have been shown to be beneficial for various conditions even if administered with full transparency. Hence, so-called open-label placebos (OLPs) offer a new way harness placebo effects ethically. To take this concept one step further, study aimed at evaluating without the use of physical placebo, i.e., by imagining taking pill. Healthy students ( N = 173) self-reported test anxiety were either randomized an imaginary pill (IP; n 55), OLP (n 59) or control group (CG; 59)....
<title>Abstract</title> The objectification of pain presents a significant clinical challenge, particularly in children, elderly individuals, patients with disabilities and unconscious patients. It is critically important to accurately assess these populations due the heightened risk undertreatment. Using cold pressor test (CPT) as induction model, we combined real-time breath metabolomics pathway analysis uncover metabolic shifts. Exhaled was analyzed discovery cohort (n=19) validated an...
Placebos are known to yield significant effects in many conditions. We examined deceptive and open-label placebo on guilt, which is important for self-regulation a symptom of mental disorders. Following an experimental induction healthy subjects were randomized (DP; n = 35), (OLP; or no treatment (NT; 39). The primary outcome was guilt responses assessed area under the curve (AUC). Secondary outcomes shame, affect. hypothesized that DP OLP would reduce compared NT. Guilt higher NT group than...
Abstract Social exclusion, that is being left out by others, can have adverse consequences for individuals’ psychological well-being. Even short-term experiences of social exclusion strongly threaten basic needs and cause so-called pain. Prior research suggests an overlap between the experience physical pain that, amongst reflected effectiveness treatments in alleviating Drawing upon these prior findings, we here explore whether open-label placebos, which previously been found to be...
Introduction: Open-label placebos have been proposed as way of using long recognized analgesic placebo effects in an ethical manner. Recent evidence shows efficacy open-label for clinical conditions, but there is need more research on acute pain. In the treatment postoperative pain, minimization opioid related side remains one key challenges. Therefore, this study aims at investigating potential adding unconditioned to usual a means reducing consumption and its patients with Methods...
Over the last years, interest in understanding health improvements that occur due to non-specific treatment effects, rather than response specific active ingredients, increased. Nevertheless, investigations on patients' idiosyncratic perspectives aspects of healing encounter or itself contribute placebo effects are still rare. The Healing Encounters and Attitudes Lists (HEAL) offer a unique parsimonious set instruments measure views variety caring encounter. HEAL items can be administered as...
The efficacy of open-label placebos (OLPs) has been increasingly demonstrated and their use holds promise for applications compatible with basic ethical principles. Taking this concept one step further an imaginary pill (IP) intervention without the a physical was developed tested in randomized controlled trial (RCT). To explore participants' experiences views, we conducted first qualitative study field IPs.A reflexive thematic analysis (RTA) semi-structured interviews test anxious students...