A5101476999- Geochemistry and Geologic Mapping
- Geological Modeling and Analysis
- Cellular transport and secretion
- Hydrocarbon exploration and reservoir analysis
- Neuroscience and Neuropharmacology Research
- Memory and Neural Mechanisms
- RNA modifications and cancer
- Plant Molecular Biology Research
- Lipid metabolism and biosynthesis
- Calcium signaling and nucleotide metabolism
- Soil Geostatistics and Mapping
- Nerve injury and regeneration
- Autism Spectrum Disorder Research
- Autophagy in Disease and Therapy
- Stress Responses and Cortisol
- Photosynthetic Processes and Mechanisms
- Plant Virus Research Studies
- RNA Research and Splicing
- Polysaccharides and Plant Cell Walls
- Plant Reproductive Biology
- Corporate Identity and Reputation
- Employer Branding and e-HRM
- Aluminum toxicity and tolerance in plants and animals
- Plant Stress Responses and Tolerance
- Ferroptosis and cancer prognosis
Southern University of Science and Technology
2021-2025
Beijing Electronic Science and Technology Institute
2024
Tongji University
2023
Guiyang Medical University
2022
Fudan University
2014-2021
China University of Geosciences (Beijing)
2015-2021
China University of Geosciences
2021
Sichuan University
2020
Sun Yat-sen University
2018
Third Affiliated Hospital of Sun Yat-sen University
2018
Significance The exocyst complex is a conserved protein that tethers the secretory vesicles to site of membrane fusion during exocytosis, an essential cellular process transports molecules, such as protein, cell surface or extracellular space. We identified small molecule targets EXO70 (exocyst component 70 kDa) subunit inhibit exocytosis. This compound made it possible control dynamics exocytosis in dosage-dependent manner different organisms and overcame mutant lethality genetic redundancy...
The Hongdonggou Pb-Zn polymetallic ore deposit, located in the southwestern part of Luanchuan Mo-W-Pb-Zn-Ag mineralization Henan Province, China, is an important East Qinling metallogenic belt. orebodies which are vein, bedded and lenticular, mainly hosted syenite porphyry, formed within carbonate clastic rocks Yuku Qiumugou formations partially. genesis deposit has previously been argued to be hydrothermal-vein type or skarn-hydrothermal type. In this study, we report results Rb-Sr isotopic...
The homotypic fusion and protein sorting (HOPS) complex is a conserved, multi-subunit tethering in eukaryotic cells. In yeast mammalian cells, the HOPS subunit vacuolar sorting-associated 41 (VPS41) recruited to late endosomes after Ras-related 7 (Rab7) activation essential for vacuole fusion. However, whether VPS41 plays conserved roles plants not clear. Here, we demonstrate that model plant Arabidopsis (Arabidopsis thaliana), localizes distinct condensates root cells addition its reported...
The primary cell wall is a fundamental plant constituent that flexible but sufficiently rigid to support the shape. Although many studies have demonstrated reactive oxygen species (ROS) serve as important signaling messengers modify structure and affect cellular growth, regulatory mechanism underlying spatial-temporal regulation of ROS activity for maintenance remains largely unclear. Here, we demonstrate role Arabidopsis (Arabidopsis thaliana) multicopper oxidase-like protein skewed 5...
Food supply chains (FSCs) have long been exposed to environmental variability and shock events caused by various economic, political, infrastructural factors. The outbreak of the COVID-19 pandemic has further identified vulnerability FSCs, promoted integrated optimization approaches for building resilience. However, existing works focusing on general (SCs) FSCs not fully aware distinct characteristics in green logistics, i.e., expiration fresh products. In reality, perishable food materials...
While RNA silencing is crucial for plant resistance against viruses, the cellular connections between and antiviral responses in plants remain poorly understood. In this study, we aim to investigate relationship by examining subcellular localization of small loading viral replication Arabidopsis. Our findings reveal that Argonaute 2 (AGO2), a key component silencing, loads RNAs at endoplasmic reticulum (ER)–chloroplast membrane contact sites (MCSs). We identify chloroplast-localized protein,...
Accumulating evidence suggests that anti-inflammatory agents and antioxidants have neuroprotective properties may be beneficial in the treatment of neurodevelopental disorders, such as autism. In present study, possible sulindac, a non-steroidal drug (NSAID), were investigated vitro using cultured cortical neurons with valproic acid (VPA)-induced neurotoxicity, well vivo through behavioral analysis rats prenatally exposed to VPA model induced 4-hydroxynonenal (4-HNE) expression, reactive...
Pharmacological studies have suggested that the cholinergic (ACh) and noradrenergic (NA) systems in amygdala (AM) play an important role learning memory storage two interact to modulate storage. To obtain anatomical evidence for interaction, organization of ACh NA fibers rat AM was investigated by immunocytochemistry choline acetyltransferase (ChAT) dopamine-beta-hydroxylase (DBH) conjunction with light, confocal laser scanning, electron microscopy (LM, CLSM, TEM, respectively). LM showed...
Although the basolateral nucleus (BL) of amygdala is known to contain an abundance gamma-aminobutyric acid (GABA)ergic neurons that regulate amygdaloid projection and influence storage consolidation memory, it remains be determined what type neuronal input controls GABAergic in BL. We examined synapses form with noradrenergic terminals unknown transmitters by double-labeling immunoelectron microscopy using anti-GABA dopamine-beta-hydroxylase (DBH) antisera. The medium small dendrites were...
This study aimed to explore the effect of high glucose concentration on expression glial cell line-derived neurotrophic factor (GDNF) and its family ligand receptors (GFRs) GFRα1 GFRα2 in Müller cells protective role GDNF cultured under circumstance. Cultured (untreated or treated with 200 ng/mL GDNF) were exposed conditions (20 mmol/L glucose). We found that levels mRNA protein increased gradually over time exogenous GDNF-treated conditions, whereas upregulation was observed only early...
Root hairs are single-cell projections in the root epidermis. The presence of greatly expands surface, which facilitates soil anchorage and absorption water nutrients. also ideal system to study mechanism polar growth. Previous research has identified many important factors that control different stages hair development. Using a chemical genetics screen, this we report identification steroid molecule, RHP1, promotes growth at nanomolar concentrations without obvious change other...
The purpose of this report was to study the use pre-embedding immunoelectron microscopy technique with gold and horseradish peroxidase (HRP) labeling in detecting expression ubiquitin C-terminal hydrolase 1 (UCH-L1) podocytes glomerulonephritis. specimens human IgA nephropathy lupus nephritis were fixed paraformaldehyde lysine-HCl buffer, labeled by colloidal or HRP, embedded epoxy resin, examined under transmission electron microscope. high density particles reaction products (DAB) combined...