A5021411362- Cholesterol and Lipid Metabolism
- Drug Transport and Resistance Mechanisms
- Steroid Chemistry and Biochemistry
- Cyclopropane Reaction Mechanisms
- Sphingolipid Metabolism and Signaling
- Crystallization and Solubility Studies
- Systemic Lupus Erythematosus Research
- Synthesis and Reactivity of Heterocycles
- X-ray Diffraction in Crystallography
- Estrogen and related hormone effects
- Immunotherapy and Immune Responses
- HIV Research and Treatment
- Catalytic Alkyne Reactions
- Peroxisome Proliferator-Activated Receptors
- Catalytic C–H Functionalization Methods
- Immune Cell Function and Interaction
- Herpesvirus Infections and Treatments
- Asymmetric Synthesis and Catalysis
- Natural product bioactivities and synthesis
- Lipid Membrane Structure and Behavior
- Monoclonal and Polyclonal Antibodies Research
University of Perugia
2020-2025
University College London
2023
Background and Purpose Liver X receptors (LXRs) are promising therapeutic targets for alleviating Alzheimer's disease (AD) symptoms. We assessed the impact of semi‐synthetic LXR agonist 22‐ketositosterol on progression in an AD mouse model. Experimental Approach From 5.5 months age, APPswePS1ΔE9 mice wild‐type (WT) littermates received a regular or 22‐ketositosterol‐supplemented diet (0.017% w / ). Cognition was with object location recognition tasks spontaneous alternation Y‐maze test....
Abstract Lipid and cholesterol metabolism play a crucial role in tumor cell behavior shaping the microenvironment. In particular, enzymatic non-enzymatic metabolism, derived metabolites control dendritic (DC) functions, ultimately impacting antigen presentation within outside mass, dampening immunity immunotherapeutic attempts. The mechanisms accounting for such events remain largely to be defined. Here we perturbed (oxy)sterol genetically pharmacologically analyzed lipidome landscape...
The bulk solvent-free synthesis of cyclopropanes via a ball-milling-enabled Simmons–Smith reaction is herein described.
A plethora of studies have demonstrated the crucial role played by Liver X Receptors (LXRs) in cancer. However, whether LXRs activation results pro-versus anti-tumor effects is still matter debate. Recently, we reported ability 22(S)-hydroxycholesterol-3-sulfate (PFM037) to antagonize LXRα activity, and, at same time, its capability improve in-vivo immune responses. Herein report first study aimed definition structure-activity relationships PFM037. Successfully, identified...
Genital herpes, most frequently caused by herpes simplex virus 2 (HSV-2) infection, is one of the prevalent sexually transmitted infections. The current rationale for treatment HSV-2 infection involves nucleoside analogs (e.g. acyclovir) to suppress reactivation. Enzymatic oxysterols are endogenous 27-carbon atoms molecules produced enzymatic cholesterol oxidation, and recently emerged as a broad-spectrum host targeting antivirals. In this study, we screened selected members an in-house...
Steroid chemistry blossomed in the middle of last century, with discovery biological activities main steroid hormones. Today, is still a challenging and stim...