A5002374765- Mitochondrial Function and Pathology
- Muscle Physiology and Disorders
- Alzheimer's disease research and treatments
- Medicinal Plants and Neuroprotection
- Bee Products Chemical Analysis
- Drug Solubulity and Delivery Systems
- Lipid Membrane Structure and Behavior
- Genetic Neurodegenerative Diseases
- Andrographolide Research and Applications
- Nutrition and Health in Aging
- Advancements in Transdermal Drug Delivery
- Pluripotent Stem Cells Research
- Antimicrobial agents and applications
- Pleural and Pulmonary Diseases
- Advanced Drug Delivery Systems
- Essential Oils and Antimicrobial Activity
- Nanoparticle-Based Drug Delivery
- CRISPR and Genetic Engineering
- Muscle metabolism and nutrition
- Cholinesterase and Neurodegenerative Diseases
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Berberine and alkaloids research
- Wound Healing and Treatments
- Autophagy in Disease and Therapy
- Occupational and environmental lung diseases
Rashtrasant Tukadoji Maharaj Nagpur University
2020-2025
Hindu College of Pharmacy
2024
Celecoxib (CXB), with its anti-inflammatory and recently discovered antibacterial activity, especially against sensitive methicillin-resistant Staphylococcus aureus (MRSA), could be promising in treating local pain, superficial skin infections, wounds infected wounds. The study aims to develop compare commercially scalable topical formulations of CXB explore their antimicrobial wound-healing potential. Carbopol gel, o/w cream, polyethylene glycol (PEG) ointment, paraffin ointment were...
The use of topical antimicrobials in wound healing presents challenges like risk drug resistance and toxicity to local tissue. Simvastatin (SIM), a lipid-lowering agent which reduces the cardiovascular events, is repurposed for its pleiotropic effect healing. A bioactive bioadhesive polymer-based film forming spray (FFS) formulation SIM was designed using chitosan, collagen, hyaluronic acid optimised by employing DoE approach. Optimised demonstrated moderate viscosity (12.5 ± 0.3 cP), rapid...
Mitochondria are crucial cellular organelles that regulate energy production, oxidative balance, and calcium homeostasis, among other things. Aging is a natural, multifactorial, multi-organic process, in which both pathological physiological changes occur gradually over time. Autophagy capacity mitochondrial processes such as mitophagy, biogenesis, dynamics associated with aging. These important for maintaining the structural integrity of mitochondria thus cell life since dysfunction leads...
The objectives undertaken in current work were to develop a new solid self-microemulsifying drug delivery system (S-SMEDDS) for poorly water-soluble Rosuvastatin Calcium (RST) and evaluate its antihyperlipidemic activity rodent model. Solubility assessment variety of excipients, screening studies optimization pseudoternary plots helped development liquid SMEDDS. Liquid SMEDDS RST contained Capryol 90, Kolliphor EL Transcutol HP as oil phase, surfactant co-surfactant respectively which...
Parkinson's disease (PD) is amongst the most common age-related neurodegenerative disorders. Natural compounds, especially polyphenols have gained great interest as potential therapeutic agents in recent research. Thus, present study was designed to evaluate effect of polyphenolic extract Cymbopogon citratus (C. Citratus) leaves animal models PD. In given PD induced by administration reserpine (5 mg/kg/day, i.p for 5 consecutive days), haloperidol (1 mg/kg, i.p.), experimental animals. The...
Sarcopenia is a musculoskeletal disease that reduces muscle mass and strength in older individuals. The study investigates the effects of azilsartan (AZL) on skeletal loss natural sarcopenic rats. Male Sprague-Dawley rats aged 4–6 months 18–21 were selected as young-matched control natural-aged (sarcopenic) rats, respectively. Rats allocated into young old (YC OC) AZL treatment (YT OT) groups, which received vehicles (8 mg/kg, orally) for 6 weeks. then sacrificed after function analysis....
Antipsychotic-induced obesity affects millions of people and is a serious health condition worldwide. Olanzapine the most widely prescribed antipsychotic agent with high obesogenic potential. However, exact mechanism by which it causes its metabolic dysregulation remains poorly understood. In this study, we investigated effect agmatine in olanzapine-induced derangements Female Sprague-Dawley rats. Repeated olanzapine administration for 28 days increased body weight while treatment from 15 to...
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