A5033602982- Neonatal Respiratory Health Research
- Birth, Development, and Health
- Infant Development and Preterm Care
- Congenital Heart Disease Studies
- Cancer, Hypoxia, and Metabolism
- Pregnancy and preeclampsia studies
- Cardiovascular and exercise physiology
- Glycosylation and Glycoproteins Research
- Leaf Properties and Growth Measurement
- Biochemical and Molecular Research
- RNA Research and Splicing
- Mitochondrial Function and Pathology
- Cancer Research and Treatments
- Congenital Diaphragmatic Hernia Studies
- Family and Disability Support Research
- Adipose Tissue and Metabolism
- Characterization and Applications of Magnetic Nanoparticles
- Monoclonal and Polyclonal Antibodies Research
- Plant Molecular Biology Research
- Neonatal Health and Biochemistry
- Metabolomics and Mass Spectrometry Studies
- Tree Root and Stability Studies
- Neonatal and fetal brain pathology
- Greenhouse Technology and Climate Control
- RNA modifications and cancer
Centre Hospitalier Universitaire Sainte-Justine
2018-2023
Université de Montréal
2016-2023
Université Claude Bernard Lyon 1
2019
Centre National de la Recherche Scientifique
2019
Institut des Nanotechnologies de Lyon
2019
École Centrale de Lyon
2019
Centre hospitalier universitaire de Québec
2016-2017
Université Laval
2016-2017
United States Nuclear Regulatory Commission
2014
Preterm birth incurs a higher risk for adult cardiovascular diseases, including hypertension. Because preterm may impact nephrogenesis, study objectives were to assess renal size and function of adults born versus full term examine their relationship with blood pressure (BP; 24-hour ambulatory BP monitoring) circulating renin-Ang (angiotensin) system peptides. The included 92 young (1987–1997) (≤29 weeks gestation) (n=92) matched age, sex, race. Young had smaller kidneys (80±17 90±18 cm 3 /m...
Preterm birth incurs an increased risk of early cardiovascular events and death. In the general population, factors cluster in context inflammation oxidative stress. Whether this also occurs young adults born preterm is unknown. We analyzed 101 healthy (ages 18–29) (≤29 weeks gestation) 105 full-term controls, predominantly (90%) white. They underwent a comprehensive clinical biological evaluation, including measurement blood pressure, lung function (spirometry), glucose metabolism (fasting...
The analysis of biological shapes has applications in many areas biology, and tools exist to quantify organ shape detect differences between species or among variants. However, such measurements do not provide any information about the mechanisms generation. Quantitative data on growth patterns may insights into morphogenetic processes, but since is a complex process occurring four dimensions, alone cannot intuitively be linked outcomes. Here, we present computational tissue deformation...
Maintenance of cellular homeostasis and xenobiotic detoxification is mediated by 19 human UDP-glucuronosyltransferase enzymes (UGTs) encoded ten genes that comprise the glucuronidation pathway. Deep RNA sequencing major metabolic organs exposes a substantial expansion UGT transcriptome alternative splicing, with variants representing 20% to 60% canonical transcript expression. Nearly fifth expressed in-frame sequences may create distinct structural functional features. Follow-up cell-based...
This study aims to compare cardiopulmonary response aerobic exercise between young adults born very preterm, including a subgroup with bronchopulmonary dysplasia (BPD), and term controls. Seventy-one (18–29 years) <30 weeks’ gestational age (24 BPD) 73 controls were recruited. Assessment included testing impedance cardiography. We compared group differences in peak O 2 consumption (peak VO ) ventilatory cardiovascular responses using linear regression analyses. Preterm participants had...
The conjugative metabolism mediated by UDP-glucuronosyltransferase enzymes (UGTs) significantly influences the bioavailability and biological responses of endogenous molecule substrates xenobiotics including drugs. UGTs participate in regulation cellular homeostasis limiting stress induced toxic molecules, controlling hormonal signaling networks. Glucuronidation is highly regulated at genomic, transcriptional, post-transcriptional post-translational levels. However, UGT protein interaction...
Background Although erythropoiesis is impaired and anaemia frequent in neonates born preterm, haematopoiesis adults preterm has not been previously studied. Objective We, thus, aimed to evaluate haemoglobin erythropoietin levels young identify neonatal events associated with adulthood examine the relationships of respiratory function blood pressure. Methods We assessed a cohort 101 (ages 18–29) (≤29 weeks gestation), comparison 105 full-term controls. measured haemoglobin, also using...
The aim of the study was to explore how young adults thought that being born preterm had affected their lives.Adult participants a research cohort were questioned about perspectives. Answers analysed using mixed methods.Forty-five evaluated health at median score 8/10. When asked meaning preterm, 65% positive self-centred answers, invoking two main themes: stronger/'a fighter'/more resilient and survivor/chosen; 42% also reported negative themes, such as having problems difficult start. All...
The UDP glucuronosyltransferase (UGT) superfamily comprises glycoproteins that reside in the endoplasmic reticulum membranes and undergo post-translational modifications (PTMs). UGT2B7 is of particular interest because its action on a wide variety drugs. Most studies currently survey common variants examine only small fraction genetic diversity; however, rare (frequency <1%) might have significant effect they are predicted to greatly outnumber human genome. We discovered single nucleotide...
Abstract Aim This study assessed the self‐reported health perception and use of care by adults born very preterm before 30 weeks gestation. Methods The participants were part a cross‐sectional observational that global young aged 18–29 years in Quebec, Canada. Health was explored from 2011 to 2016 using second Short‐Form 36 Survey (SF‐36v2), objective measures obtained. Further in‐depth open‐ended questions asked 2018. Results 101 subjects had similar perceptions their 105 term‐born...
Individuals born preterm have reduced aerobic capacity, which could be related to impaired organ development. Their capacity improve with exercise training therefore limited, but this remains unknown. We aimed test an intervention cardiorespiratory fitness in adults preterm.Twenty-one very and 37 full-term individuals aged 18-33 yr took part a 14-wk supervised of cardiovascular, resistance, flexibility (two group one individual sessions per week). Adherence compliance were recorded. Primary...
Very preterm birth is associated with increased cardiovascular diseases and changes in myocardial structure. The current study aimed to investigate the impact of endothelial colony-forming cell (ECFC) treatment on heart morphological experimental model neonatal high oxygen (O2)-induced cardiomyopathy, mimicking prematurity-related conditions. Sprague–Dawley rat pups exposed 95% O2 or room air (RA) from day 4 (P4) 14 (P14) were randomized receive (jugular vein) exogenous human cord blood ECFC...
Arrangements formed by the lectin LecA and five different synthetic glycoclusters were studied AFM imaging combined to MD simulations. affinities differ depending on nature of core branches glycoclusters.
The heart relies on adequate mitochondrial (mito) ATP production to match myocardial demand, mostly through oxidative phosphorylation. Preterm birth (PT) results in ex utero development of an immature myocardium and PT-born individuals represent a newly recognized group at high risk cardiovascular diseases. Our has shown that newborn rats exposed oxygen (O 2 ), mimicking PT-related conditions, develop O -induced cardiomyopathy (OIC) dysfunction later life. However, whether mito impairments...
A growing number of individuals born very preterm (PT) are now entering adulthood and display risk factors for chronic health diseases. Whether diseases affects health-related quality life (HR-QoL) remains undetermined. This study aimed to assess HR-QoL in PT adults versus term-born controls (T) correlate with markers organ dysfunction. Eighty-eight (≤29 weeks’ gestational age) 88 age- sex-matched T (37–41 weeks) were recruited. They completed the Short-Form 36 Health Survey (SF-36), a...
Abstract Introduction/Background Although erythropoiesis is impaired and anemia frequent in neonates born preterm, hematopoiesis adults preterm has not been previously studied. We hypothesize that adverse neonatal events durably affect regulation, leading to a difference hemoglobin levels young compared those term. Objectives thus aimed evaluate erythropoietin identify associated with adulthood examine the relationships of respiratory function blood pressure. Design/Methods This study...