A5059517296- RNA Research and Splicing
- Cancer Genomics and Diagnostics
- Acute Myeloid Leukemia Research
- RNA modifications and cancer
- Chemokine receptors and signaling
- Lung Cancer Treatments and Mutations
- Sarcoma Diagnosis and Treatment
- Epigenetics and DNA Methylation
- HER2/EGFR in Cancer Research
- Hepatocellular Carcinoma Treatment and Prognosis
- Genetics and Neurodevelopmental Disorders
- Acute Lymphoblastic Leukemia research
- Cancer-related Molecular Pathways
- Multiple Myeloma Research and Treatments
- Cancer Cells and Metastasis
- Genetic factors in colorectal cancer
- Cell death mechanisms and regulation
Kantonsspital St. Gallen
2021
University Children's Hospital Tübingen
2019
University of Crete
2015
Circulating tumor cells (CTCs) are important for metastatic dissemination of cancer. They can provide useful information, regarding biological features and heterogeneity; however, their detection characterization difficult due to limited number in the bloodstream mesenchymal characteristics. Therefore, new biomarkers needed address these questions.Bioinformatics functional enrichment analysis revealed a subgroup 24 genes, potentially overexpressed CTCs. Among chemokine receptor CXCR4 plays...
BackgroundApoptosis-stimulating Protein of TP53-2 (ASPP2) is a tumor suppressor enhancing TP53-mediated apoptosis via binding to the TP53 core domain. mutations found in cancers disrupt ASPP2 binding, arguing for an important role suppression. We now identify oncogenic splicing variant, ASPP2κ, with high prevalence acute leukemia.MethodsAn mRNA screen detect variants was performed and ASPP2κ validated using isoform-specific PCR approaches. Translation into genuine protein isoform evaluated...
BackgroundOverriding the differentiation blockage in acute myeloid leukemia (AML) is most successful mode-of-action therapy – now curing vast majority of patients with promyelocytic (APL) using all-trans retinoic acid (ATRA)-based regimens. Similar approaches other subtypes, such as IDH1/2-mutated AML, are under active investigation. We herein present release upon treatment natural (−)-Δ9-Tetrahydrocannabinol isomer dronabinol vitro and vivo.MethodsCellular maturation were followed two...
Alternative splicing is a common physiologic mechanism to generate numerous distinct gene products from one locus, which can result in unique with differing important functional outcomes depending on cell context. Aberrant alternative hallmark of cancer that contribute oncogenesis and aggressiveness the disease as well resistance therapy. However, aberrant might also novel targets for ASPP2 haplo-insufficient tumor suppressor, functions through both p53-dependent p53-independent mechanisms...
Abstract Introduction: Bioinformatics’ analysis regarding gene expression in Normal tissue vs cancer tissue, blood patients’ and revealed a subgroup of 24 genes which potentially could be overexpressed CTCs. Among these are: CXCR4, chemokine receptor is involved tumor metastasis and, JUNB transcription factor participating CXCR4 pathway. The objective this study was to confirm the results bioinformatics’ samples from breast patients therefore evaluate Methods: Triple staining...
Metastatic soft tissue sarcoma (STS) are a heterogeneous group of malignancies which not curable with chemotherapy alone. Therefore, understanding the molecular mechanisms sarcomagenesis and therapy resistance remains critical clinical need. ASPP2 is tumor suppressor, that functions through both p53-dependent p53-independent mechanisms. We recently described dominant-negative isoform (ASPP2κ), overexpressed in human leukemias to promote resistance. However, ASPP2κ has never been studied STS....