A5042853695- Optical Network Technologies
- Photonic Crystal and Fiber Optics
- Advanced Fiber Laser Technologies
- Advanced biosensing and bioanalysis techniques
- Molecular Junctions and Nanostructures
- Spectroscopy and Quantum Chemical Studies
- Photonic and Optical Devices
- Lipid Membrane Structure and Behavior
- Covalent Organic Framework Applications
- Antimicrobial Peptides and Activities
- 2D Materials and Applications
- Monoclonal and Polyclonal Antibodies Research
- Protein Structure and Dynamics
- Advanced Biosensing Techniques and Applications
- Advanced Photonic Communication Systems
- Graphene research and applications
- Advanced Sensor and Energy Harvesting Materials
- Nanowire Synthesis and Applications
- NMR spectroscopy and applications
- DNA and Nucleic Acid Chemistry
- Silicon Nanostructures and Photoluminescence
- Advanced Nanomaterials in Catalysis
- Recommender Systems and Techniques
- Photonic Crystals and Applications
- Advanced Fiber Optic Sensors
Jiangsu University
2025
Chinese Academy of Medical Sciences & Peking Union Medical College
2025
Xinyang Normal University
2025
State Key Laboratory of Transducer Technology
2021-2024
Shanghai Institute of Microsystem and Information Technology
2021-2024
University of Chinese Academy of Sciences
2021-2024
Guangdong Ocean University
2024
Hefei University
2024
Guilin University of Electronic Technology
2024
China Coal Technology and Engineering Group Corp (China)
2021-2022
Proper treatment of nonbonded interactions is essential for the accuracy molecular dynamics (MD) simulations, especially in studies lipid bilayers. The use CHARMM36 force field (C36 FF) different MD simulation programs can result disagreements with published simulations performed CHARMM due to differences protocols used treat long-range and 1-4 interactions. In this study, we systematically test C36 FF NAMD, GROMACS, AMBER, OpenMM, CHARMM/OpenMM. A wide range Lennard-Jones (LJ) cutoff...
The piezo-phototronic effect has been promising as an effective means to improve the performance of two-dimensional (2D) semiconductor based optoelectronic devices. However, current reported monolayer 2D semiconductors are not regarded suitable for actual flexible piezotronic photodetectors due their insufficient optical absorption and mechanical durability, although they possess strong piezoelectricity. In this work, we demonstrate that, unlike 2H-phase transition-metal dichalcogenides,...
Applications of graphene have extended into areas nanobio-technology such as nanobio-medicine, nanobio-sensing, well nanoelectronics with biomolecules. These applications involve interactions between proteins, peptides, DNA, RNA etc. and graphene, therefore understanding molecular is essential. For example, many based on using peptides require to interact (e.g., noncovalently bind to) at one end, while simultaneously exposing the other end surrounding medium detect analytes in solution). To...
A microstructured graphene array-based flexible sensor can measure the three-axis tactile force at a high sensitivity of −1.71 kPa<sup>−1</sup>with an ultrafast response 6 ms.
Molecular structural information on a Chinese Xishan bituminous coal was obtained using elemental analysis, high resolution transmission electron microscope (HRTEM), laser desorption time-of-flight mass spectrometry (LD-TOF MS), solid state 13C nuclear magnetic resonance (NMR), and X-ray photoelectron spectroscopy (XPS) techniques. The size distribution of aromatic structures were determined by HRTEM, providing 300 base skeletons for model. Aliphatic side chains heteroatoms introduced into...
Immobilization on solid supports provides an effective way to improve enzyme stability and simplify downstream processing for biotechnological applications, which has been widely used in research applications. However, surface immobilization may disrupt structure due interactions between the supporting substrate, leading a loss of catalytic efficiency stability. Here, we use model enzyme, nitroreductase (NfsB), demonstrate that engineered variants with two strategically positioned...
Antimicrobial peptides, because of their unique structural and chemical properties, hold a promising future for the development new class bacterial-resistant antibiotics, effective antimicrobial coatings, high performance biosensors. To understand structure/function relationship surface-bound peptides as they relate to such applications, sum frequency generation (SFG) vibrational spectroscopy, coarse grained molecular dynamics simulations, activity tests were used characterize both surface...
Seed weight (SW) is one of three determinants seed yield, which positively correlates with silique length (SL) in Brassica napus (rapeseed). However, the genetic mechanism underlying relationship between and largely unknown at present. A natural population comprising 157 inbred lines rapeseed was genotyped by whole-genome re-sequencing investigated for SW SL over four years. The genome-wide association study identified 20 SNPs significant on A01, A04, A09, C02, C06 chromosomes phenotypic...
The interaction of proteins with surfaces is important in numerous applications many fields—such as biotechnology, proteomics, sensors, and medicine—but fundamental understanding how protein stability structure are affected by remains incomplete. Over the last several years, molecular simulation using coarse grain models has yielded significant insights, but formalisms used to represent surface interactions have been rudimentary. We present a new model for that incorporates chemical...
Tethering peptides and proteins to abiotic surfaces has the potential create biomolecule-functionalized with useful properties.
Surface-immobilized enzymes are important for a wide range of technological applications, including industrial catalysis, drug delivery, medical diagnosis, and biosensors; however, our understanding how proteins interact with abiological surfaces on the molecular level remains extremely limited. We have compared structure, activity, thermal stability two variants β-galactosidase attached to chemically well-defined maleimide-terminated self-assembled monolayer surface through unique cysteinyl...
Two-dimensional (2D) materials such as graphene, molybdenum disulfide (MoS2), tungsten diselenide (WSe2), and black phosphorous are being developed for sensing applications with excellent selectivity high sensitivity. In applications, 2D extensively interact various analytes including biological molecules. Understanding the interfacial molecular interactions of targets becomes increasingly important progression better-performing 2D-material based sensors. this research, between several de...
Single layered two-dimensional (2D) materials such as transition metal dichalcogenides (TMDs) show great potential in many microelectronic or nanoelectronic applications. For example, because of extremely high sensitivity, TMD-based biosensors have become promising candidates for next-generation label-free detection. However, very few studies been conducted on understanding the fundamental interactions between TMDs and other molecules including biological molecules, making rational design...
Tin disulfide (SnS2) has a larger band gap (>2.0 eV) than other two-dimensional (2D) materials, which can achieve higher on/off current ratio, much lower off-current, and standby power dissipation in future electronics. However, the defects SnS2, such as sulfur vacancies, always result very low carrier mobility are far behind their theoretical values. Herein, we report synergistic effect of vacancy repairing electron doping on SnS2 sheets introduced by ethylenediaminetetraacetic acid (EDTA)...
The family Circoviridae includes the genera Circovirus and Cyclovirus. Cycloviruses have been found in serum samples from chronic HBV, HCV, or HIV-infected individuals as well asymptomatic blood donors. However, research on cycloviruses is relatively limited. We used viral metagenomics to mine, analyze, visualize human virome, successfully identifying three new genomes, each encoding Rep Capsid proteins. These proteins are crucial for replication host-cell interaction: protein involved...
Alveolar bone grafting during the mixed dentition period is a common treatment, but optimal surgical timing remains unclear. This study aims to evaluate how age influences outcomes of secondary alveolar cleft repair, focusing on formation and midfacial symmetry. retrospectively analyzed patients who underwent autologous iliac cancellous for repair from January 2019 August 2023. Preoperative 1-year postoperative skull CT data were used measure osteogenesis rate and midface bony structures,...
Abstract An asymmetric dual‐gate heterointerface‐regulated artificial synapse (HRAS) is developed, utilizing a main gate with distinct ion concentrations and lateral to receive synaptic pulses, through dielectric coupling ionic effects, formed indium tin zinc oxide (ITZO) dual‐interface channels that allow precise control over channel charge, thereby simulating multi‐level coordinated actions of dual‐neurotransmitters. The modulation the significantly regulates achieving intricate interplay...
Both end-functionalized (alpha-bromo and omega-carboxy) compounds were first tested for the radical reaction on silicon-hydride (Si-H) terminated porous silicon (PSi) with/without presence of diacyl peroxide initiator under microwave irradiation. Then carboxylic acid monolayers (CAMs) assembled PSi through robust Si-C bonds converted to amino-reactive linker, N-hydroxysuccinimide (NHS)-ester, monolayers. And finally two proteins bovine serum albumin (BSA) lysozyme (Lys) immobilized amide...
Understanding the fundamental biophysics behind protein–nanoparticle (NP) interactions is essential for design and engineering bio‐NP systems. The authors describe development of a coarse‐grained protein–NP model that utilizes structure centric protein model. A key feature quantitative inclusion hydrophobic character residues in their with NP surface. In addition, curvature taken into account, capturing behavior on NPs different size. evaluate this by comparison experimental results...
Surface immobilized enzymes have been widely used in many applications such as biosensors, biochips, biofuel production, and cell construction. Many factors dictate how enzymes' structure, activity, stability may change when immobilized, including surface functionalization, immobilization chemistry, nature of the solid support, enzyme density. To better understand affects structure we developed a method to measure both surface-sensitive protein vibrational spectra enzymatic activity...
We report sequence isomerism-dependent and reversible self-assembly behaviors of glycopeptide mimetics in response to different stimuli. Based on the mimetic assemblies, ON/OFF switching biofilm disruption was achieved.
Protein/surface interactions are important in a variety of fields and devices, yet fundamental understanding the relevant phenomena remains fragmented due to resolution limitations experimental techniques. Molecular simulation has provided useful answers, but such studies have focused on proteins that fold through two-state process. This study uses show how surfaces can affect which multistate process by investigating folding mechanism lysozyme (PDB ID: 7LZM). The results demonstrate bulk...